Thesis: Fanny POTZEHA

207 publications found

2022


Sex-specificities in anxiety and depressive symptoms across the lifespan and their links with multimodal neuroimaging.
Moulinet I, Landeau B, Touron E, De La Sayette V, Desgranges B, Vivien D, Marchant N, Poisnel G, Chételat G
J Affect Disord 1573-2517
PMID : 34637806
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2021


Roles of the tissue-type plasminogen activator in immune response.
Seillier C, Hélie P, Petit G, Vivien D, Clemente D, Le Mauff B, Docagne F, Toutirais O
Cell Immunol 1090-2163
PMID : 34781155
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An updated model of hydrocephalus in sheep to evaluate the performance of a device for ambulatory wireless monitoring of cerebral pressure through shunts.
Perrotte M, Lazardeux J, Sistiaga PP, Chazalviel L, Saulnier R, Metayer T, Isnard C, Emery E, Auvray P, Vivien D, Gaberel T
Neurochirurgie 1773-0619
PMID : 34774581
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Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit.
Gilbert A, Elorza-Vidal X, Rancillac A, Chagnot A, Yetim M, Hingot V, Deffieux T, Boulay AC, Alvear-Perez R, Cisternino S, Martin S, Taïb S, Gelot A, Mignon V, Favier M, Brunet I, Declèves X, Tanter M, Estevez R, Vivien D, Saubaméa B, Cohen-Salmon M
Elife 2050-084X
PMID : 34723793
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Harmonisation and Between-Country Differences of the Lifetime of Experiences Questionnaire in Older Adults.
Ourry V, Marchant NL, Schild AK, Coll-Padros N, Klimecki OM, Krolak-Salmon P, Goldet K, Reyrolle L, Bachelet R, Sannemann L, Meiberth D, Demnitz-King H, Whitfield T, Botton M, Lebahar J, Gonneaud J, de Flores R, Molinuevo JL, Jessen F, Vivien D, de la Sayette V, Valenzuela MJ, Rauchs G, Wirth M, Chételat G, Arenaza-Urquijo EM,
Front Aging Neurosci 1663-4365
PMID : 34720992
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Subjective cognitive decline: opposite links to neurodegeneration across the Alzheimer's continuum.
Kuhn E, Perrotin A, Tomadesso C, André C, Sherif S, Bejanin A, Touron E, Landeau B, Mezenge F, Vivien D, De La Sayette V, Chételat G,
Brain Commun 2632-1297
PMID : 34704027
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Molecular Magnetic Resonance Imaging of Vascular Inflammation After Recanalization in a Rat Ischemic Stroke Model.
Franx BAA, Van der Toorn A, Van Heijningen C, Vivien D, Bonnard T, Dijkhuizen RM
Stroke 1524-4628
PMID : 34674544
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Post-acute delivery of α5-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke.
Lebrun F, Violle N, Letourneur A, Muller C, Fischer N, Levilly A, Orset C, Sors A, Vivien D
Exp Neurol 1090-2430
PMID : 34597681
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Making Visible the Invisible.
Vivien D
Neuroscience 1873-7544
PMID : 34583818

Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia.
Thiebaut AM, Buendia I, Ginet V, Lemarchand E, Boudjadja MB, Hommet Y, Lebouvier L, Lechevallier C, Maillasson M, Hedou E, Déglon N, Oury F, Rubio M, Montaner J, Puyal J, Vivien D, Roussel BD
Autophagy 1554-8635
PMID : 34520334
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Retreatment of previously treated intracranial aneurysm: Procedural complications and risk factors for complications.
Metayer T, Lechanoine F, Bougaci N, de Schlichting E, Terrier L, Derrey S, Barbier C, Papagiannaki C, Ashraf A, Tahon F, Leplus A, Gay E, Emery E, Briant AR, Vivien D, Gaberel T
Neurochirurgie 1773-0619
PMID : 34487752
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Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy.
Zenych A, Jacqmarcq C, Aid R, Fournier L, Forero Ramirez LM, Chaubet F, Bonnard T, Vivien D, Letourneur D, Chauvierre C
Biomaterials 1878-5905
PMID : 34482087
KEYWORDS : Animals|Endothelial Cells|Fibrinolysis|Fibrinolytic Agents|therapeutic use|Mice|Polysaccharides|therapeutic use|Stroke|drug therapy|Thrombolytic Therapy|Tissue Plasminogen Activator|therapeutic use
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Engineered extracellular vesicles as brain therapeutics.
Lino MM, Simões S, Tomatis F, Albino I, Barrera A, Vivien D, Sobrino T, Ferreira L
J Control Release 1873-4995
PMID : 34428481
KEYWORDS : Blood-Brain Barrier|Brain|Brain Diseases|drug therapy|Drug Delivery Systems|Extracellular Vesicles|Humans
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Role of inflammation in alcohol-related brain abnormalities: a translational study.
Lanquetin A, Leclercq S, de Timary P, Segobin S, Naveau M, Coulbault L, Maccioni P, Lorrai I, Colombo G, Vivien D, Rubio M, Pitel AL
Brain Commun 2632-1297
PMID : 34396111
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White matter hyperintensity topography in Alzheimer's disease and links to cognition.
Garnier-Crussard A, Bougacha S, Wirth M, Dautricourt S, Sherif S, Landeau B, Gonneaud J, De Flores R, de la Sayette V, Vivien D, Krolak-Salmon P, Chételat G
Alzheimers Dement 1552-5279
PMID : 34322985
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Longitudinal Changes in Hippocampal Network Connectivity in Alzheimer's Disease.
Dautricourt S, de Flores R, Landeau B, Poisnel G, Vanhoutte M, Delcroix N, Eustache F, Vivien D, de la Sayette V, Chételat G
Ann Neurol 1531-8249
PMID : 34279043
KEYWORDS : Aged|Aged, 80 and over|Alzheimer Disease|diagnostic imaging|Cross-Sectional Studies|Female|Hippocampus|diagnostic imaging|Humans|Longitudinal Studies|Magnetic Resonance Imaging|trends|Male|Middle Aged|Nerve Net|diagnostic imaging|Positron Emission Tomography Computed Tomography|trends
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HGF and MET: From Brain Development to Neurological Disorders.
Desole C, Gallo S, Vitacolonna A, Montarolo F, Bertolotto A, Vivien D, Comoglio P, Crepaldi T
Front Cell Dev Biol 2296-634X
PMID : 34179015
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Combination treatment with U0126 and rt-PA prevents adverse effects of the delayed rt-PA treatment after acute ischemic stroke.
Orset C, Arkelius K, Anfray A, Warfvinge K, Vivien D, Ansar S
Sci Rep 2045-2322
PMID : 34099834
KEYWORDS : Animals|Butadienes|pharmacokinetics|Disease Models, Animal|Drug Discovery|Drug Therapy, Combination|Drug-Related Side Effects and Adverse Reactions|prevention & control|Hemorrhage|prevention & control|Humans|Ischemic Stroke|drug therapy|Male|Matrix Metalloproteinase 9|metabolism|Mice|Mitogen-Activated Protein Kinase Kinases|metabolism|Nitriles|pharmacokinetics|Signal Transduction|Tissue Plasminogen Activator|pharmacology|Treatment Outcome
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New Approaches in Nanomedicine for Ischemic Stroke.
Correa-Paz C, da Silva-Candal A, Polo E, Parcq J, Vivien D, Maysinger D, Pelaz B, Campos F
Pharmaceutics 1999-4923
PMID : 34065179
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Factor XII protects neurons from apoptosis by epidermal and hepatocyte growth factor receptor-dependent mechanisms.
Garnier E, Levard D, Ali C, Buendia I, Hommet Y, Gauberti M, Crepaldi T, Comoglio P, Rubio M, Vivien D, Docagne F, Martinez de Lizarrondo S
J Thromb Haemost 1538-7836
PMID : 34060720
KEYWORDS : Animals|Apoptosis|Blood Coagulation|Factor XII|Factor XIIa|Mice|Neurons|Proto-Oncogene Proteins c-met
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PI3KC2β inactivation stabilizes VE-cadherin junctions and preserves vascular integrity.
Anquetil T, Solinhac R, Jaffre A, Chicanne G, Viaud J, Darcourt J, Orset C, Geuss E, Kleinschnitz C, Vanhaesebroeck B, Vivien D, Hnia K, Larrue V, Payrastre B, Gratacap MP
EMBO Rep 1469-3178
PMID : 33880878
KEYWORDS : Adherens Junctions|metabolism|Animals|Antigens, CD|metabolism|Cadherins|genetics|Capillary Permeability|Endothelial Cells|metabolism|Endothelium, Vascular|metabolism|Mice|Phosphatidylinositol 3-Kinases|genetics
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Thrombolytic strategies for ischemic stroke in the thrombectomy era.
Gauberti M, Martinez de Lizarrondo S, Vivien D
J Thromb Haemost 1538-7836
PMID : 33834615
KEYWORDS : Brain Ischemia|drug therapy|Fibrinolysis|Fibrinolytic Agents|therapeutic use|Humans|Ischemic Stroke|Stroke|diagnosis|Thrombectomy|Thrombolytic Therapy|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
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Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome.
Kement D, Reumann R, Schostak K, Voß H, Douceau S, Dottermusch M, Schweizer M, Schlüter H, Vivien D, Glatzel M, Galliciotti G
Front Neuroanat 1662-5129
PMID : 33708076
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Preventing the Long-term Effects of General Anesthesia on the Developing Brain: How Translational Research can Contribute.
Salaün JP, Poirel N, Dahmani S, Chagnot A, Gakuba C, Ali C, Gérard JL, Hanouz JL, Orliaguet G, Vivien D
Neuroscience 1873-7544
PMID : 33675916
KEYWORDS : Anesthesia, General|adverse effects|Anesthetics|Brain|Child|Humans|Neurotoxicity Syndromes|Translational Medical Research
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Blood Biomarkers to Differentiate Ischemic and Hemorrhagic Strokes.
Bustamante A, Penalba A, Orset C, Azurmendi L, Llombart V, Simats A, Pecharroman E, Ventura O, Ribó M, Vivien D, Sanchez JC, Montaner J
Neurology 1526-632X
PMID : 33674361
KEYWORDS : Aged|Aged, 80 and over|Biomarkers|blood|Female|Hemorrhagic Stroke|blood|Humans|Ischemic Stroke|blood|Male|Sensitivity and Specificity
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Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses.
Hélie P, Camacho-Toledano C, Lesec L, Seillier C, Miralles AJ, Ortega MC, Guérit S, Lebas H, Bardou I, Vila-Del Sol V, Vivien D, Le Mauff B, Clemente D, Docagne F, Toutirais O
J Neuroinflammation 1742-2094
PMID : 33610187
KEYWORDS : Animals|Encephalomyelitis, Autoimmune, Experimental|blood|Female|Humans|Lymphocyte Activation|drug effects|Male|Mice|Mice, 129 Strain|Mice, Inbred C57BL|Mice, Knockout|Mice, Transgenic|Myeloid Cells|drug effects|Tissue Plasminogen Activator|deficiency
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New Opportunities for Diagnosis and Prognosis of Stroke: The Benefits of Across Border Approaches.
Vivien D
Hamostaseologie 2567-5761
PMID : 33588450
KEYWORDS : Humans|Prognosis|Stroke|diagnosis
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Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults.
Ourry V, Gonneaud J, Landeau B, Moulinet I, Touron E, Dautricourt S, Le Du G, Mézenge F, André C, Bejanin A, Sherif S, Marchant NL, Paly L, Poisnel G, Vivien D, Chocat A, Quillard A, Ferrand Devouge E, de la Sayette V, Rauchs G, Arenaza-Urquijo EM, Chételat G,
Neuroimage 1095-9572
PMID : 33549750
KEYWORDS : Aged|Aged, 80 and over|Aging|physiology|Brain|diagnostic imaging|Diffusion Magnetic Resonance Imaging|methods|Female|Humans|Independent Living|psychology|Male|Molecular Imaging|methods|Quality of Life|psychology
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Rate of Rebleed and Retreatment of Previously Treated Intracranial Aneurysms.
Metayer T, Terrier L, de Schlichting E, Lechanoine F, Bougaci N, Derrey S, Barbier C, Papagiannaki C, Ashraf A, Tahon F, Leplus A, Naveau M, Gay E, Emery E, Lonjon M, Vivien D, Gaberel T
World Neurosurg 1878-8769
PMID : 33497825
KEYWORDS : Adult|Aged|Aneurysm, Ruptured|therapy|Cohort Studies|Endovascular Procedures|methods|Female|Follow-Up Studies|Humans|Intracranial Aneurysm|therapy|Kaplan-Meier Estimate|Male|Microsurgery|methods|Middle Aged|Postoperative Complications|epidemiology|Recurrence|Reoperation|statistics & numerical data|Retreatment|statistics & numerical data|Survival Analysis
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Single- and two- chain tissue type plasminogen activator treatments differentially influence cerebral recovery after stroke.
Anfray A, Brodin C, Drieu A, Potzeha F, Dalarun B, Agin V, Vivien D, Orset C
Exp Neurol 1090-2430
PMID : 33453214
KEYWORDS : Animals|Fibrinolytic Agents|pharmacology|Male|Mice|Recombinant Proteins|pharmacology|Recovery of Function|drug effects|Stroke|Tissue Plasminogen Activator|pharmacology
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Filling the gaps on stroke research: Focus on inflammation and immunity.
Levard D, Buendia I, Lanquetin A, Glavan M, Vivien D, Rubio M
Brain Behav Immun 1090-2139
PMID : 33017613
KEYWORDS : Animals|Brain Ischemia|drug therapy|Comorbidity|Disease Models, Animal|Humans|Immunity|immunology|Inflammation|immunology|Neuroprotection|immunology|Outcome Assessment, Health Care|Reperfusion|methods|Stroke|immunology|Stroke Rehabilitation|methods
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A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs.
Debatisse J, Wateau O, Cho TH, Costes N, Mérida I, Léon C, Langlois JB, Taborik F, Verset M, Portier K, Aggour M, Troalen T, Villien M, Makris N, Tourvieille C, Bars DL, Lancelot S, Confais J, Oudotte A, Nighoghossian N, Ovize M, Vivien D, Contamin H, Agin V, Canet-Soulas E, Eker OF
J Cereb Blood Flow Metab 1559-7016
PMID : 32428423
KEYWORDS : Animals|Behavior, Animal|Blood-Brain Barrier|Disease Models, Animal|Endovascular Procedures|methods|Executive Function|Infarction, Middle Cerebral Artery|diagnostic imaging|Ischemic Stroke|diagnostic imaging|Macaca fascicularis|Magnetic Resonance Imaging|Male|Motor Skills|Positron-Emission Tomography|Reperfusion Injury|Thrombectomy|methods|Tomography, X-Ray Computed|Treatment Outcome
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2020


EZH2 inhibition reduces cartilage loss and functional impairment related to osteoarthritis.
Allas L, Brochard S, Rochoux Q, Ribet J, Dujarrier C, Veyssiere A, Aury-Landas J, Grard O, Leclercq S, Vivien D, Ea HK, Maubert E, Cohen-Solal M, Boumediene K, Agin V, Baugé C
Sci Rep 2045-2322
PMID : 33177650
KEYWORDS : Aged|Aged, 80 and over|Animals|Benzamides|pharmacology|Biphenyl Compounds|pharmacology|Cartilage, Articular|drug effects|Chondrocytes|drug effects|Disease Models, Animal|Enhancer of Zeste Homolog 2 Protein|antagonists & inhibitors|Gene Expression Regulation|Humans|Interleukin-1beta|pharmacology|Male|Mice, Inbred C57BL|Middle Aged|Morpholines|pharmacology|Nerve Growth Factor|metabolism|Organ Culture Techniques|Osteoarthritis|pathology|Pyridones|pharmacology
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White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition.
Garnier-Crussard A, Bougacha S, Wirth M, André C, Delarue M, Landeau B, Mézenge F, Kuhn E, Gonneaud J, Chocat A, Quillard A, Ferrand-Devouge E, de La Sayette V, Vivien D, Krolak-Salmon P, Chételat G
Alzheimers Res Ther 1758-9193
PMID : 33032654
KEYWORDS : Aged|Brain|diagnostic imaging|Cognition|Humans|Longevity|Magnetic Resonance Imaging|Middle Aged|Neuropsychological Tests|White Matter|diagnostic imaging
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Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice.
Fournier AP, Martinez de Lizarrondo S, Rateau A, Gerard-Brisou A, Waldner MJ, Neurath MF, Vivien D, Docagne F, Gauberti M
Sci Transl Med 1946-6242
PMID : 32908005
KEYWORDS : Animals|Humans|Immunoglobulins|Inflammation|Intestinal Mucosa|Leukocytes|Mice|Molecular Imaging|Mucoproteins
Show abstract [+]

Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor.
Wagnon I, Hélie P, Bardou I, Regnauld C, Lesec L, Leprince J, Naveau M, Delaunay B, Toutirais O, Lemauff B, Etard O, Vivien D, Agin V, Macrez R, Maubert E, Docagne F
Brain 1460-2156
PMID : 32893288
KEYWORDS : Animals|Autoantibodies|blood|B-Lymphocytes|immunology|Encephalitis|blood|Hashimoto Disease|blood|Male|Mice|Mice, Inbred C57BL|Nerve Tissue Proteins|immunology|Receptors, N-Methyl-D-Aspartate|immunology
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An overview of the perspectives on experimental models and new therapeutic targets in giant cell arteritis.
Deshayes S, de Boysson H, Dumont A, Vivien D, Manrique A, Aouba A
Autoimmun Rev 1873-0183
PMID : 32810608
KEYWORDS : Aortic Aneurysm|Aortitis|Giant Cell Arteritis|Humans|Models, Theoretical|Temporal Arteries
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Validation of a stroke model in rat compatible with rt-PA-induced thrombolysis: new hope for successful translation to the clinic.
Arkelius K, Vivien D, Orset C, Ansar S
Sci Rep 2045-2322
PMID : 32699371
KEYWORDS : Animals|Brain|diagnostic imaging|Disease Models, Animal|Fibrinolytic Agents|therapeutic use|Magnetic Resonance Imaging|Male|Middle Cerebral Artery|Rats|Rats, Wistar|Stroke|diagnostic imaging|Thromboembolism|drug therapy|Tissue Plasminogen Activator|therapeutic use
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Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice.
Hingot V, Brodin C, Lebrun F, Heiles B, Chagnot A, Yetim M, Gauberti M, Orset C, Tanter M, Couture O, Deffieux T, Vivien D
Theranostics 1838-7640
PMID : 32685000
KEYWORDS : Animals|Brain|blood supply|Cerebrovascular Circulation|Disease Models, Animal|Fibrinolytic Agents|administration & dosage|Humans|Intravital Microscopy|instrumentation|Magnetic Resonance Imaging|Male|Mice|Middle Cerebral Artery|diagnostic imaging|Proof of Concept Study|Recombinant Proteins|administration & dosage|Thrombolytic Therapy|Thrombotic Stroke|chemically induced|Time Factors|Tissue Plasminogen Activator|administration & dosage|Ultrasonography, Doppler|instrumentation
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Fast Stent Retrieval Improves Recanalization Rates of Thrombectomy: Experimental Study on Different Thrombi.
Soize S, Pierot L, Mirza M, Gunning G, Gilvarry M, Gawlitza M, Vivien D, Zuber M, Touzé E
AJNR Am J Neuroradiol 1936-959X
PMID : 32409312
KEYWORDS : Aged|Brain Ischemia|etiology|Female|Humans|Male|Models, Anatomic|Stroke|etiology|Thrombectomy|instrumentation|Thrombosis|complications|Time Factors
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Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial.
André C, Rehel S, Kuhn E, Landeau B, Moulinet I, Touron E, Ourry V, Le Du G, Mézenge F, Tomadesso C, de Flores R, Bejanin A, Sherif S, Delcroix N, Manrique A, Abbas A, Marchant NL, Lutz A, Klimecki OM, Collette F, Arenaza-Urquijo EM, Poisnel G, Vivien D, Bertran F, de la Sayette V, Chételat G, Rauchs G,
JAMA Neurol 2168-6157
PMID : 32202593
KEYWORDS : Aged|Alzheimer Disease|Amyloidogenic Proteins|metabolism|Biomarkers|analysis|Brain|metabolism|Cross-Sectional Studies|Female|Gray Matter|pathology|Humans|Independent Living|Male|Middle Aged|Positron-Emission Tomography|Sleep Apnea Syndromes|complications
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Cranioplasty Reverses Dysfunction of the Solutes Distribution in the Brain Parenchyma After Decompressive Craniectomy.
Borha A, Chagnot A, Goulay R, Emery E, Vivien D, Gaberel T
Neurosurgery 1524-4040
PMID : 32097469
KEYWORDS : Animals|Brain|metabolism|Brain Injuries, Traumatic|surgery|Cerebrospinal Fluid|metabolism|Decompressive Craniectomy|adverse effects|Extracellular Fluid|metabolism|Glymphatic System|metabolism|Male|Mice|Reconstructive Surgical Procedures|Skull|surgery
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Alcohol exposure-induced neurovascular inflammatory priming impacts ischemic stroke and is linked with brain perivascular macrophages.
Drieu A, Lanquetin A, Levard D, Glavan M, Campos F, Quenault A, Lemarchand E, Naveau M, Pitel AL, Castillo J, Vivien D, Rubio M
JCI Insight 2379-3708
PMID : 31990687
KEYWORDS : Alcohol Drinking|Animals|Biomarkers|metabolism|Blood Vessels|cytology|Brain Ischemia|chemically induced|Ethanol|toxicity|Female|Humans|Inflammation|metabolism|Ischemic Stroke|chemically induced|Macrophages|drug effects|Male|Mice|Vasculitis|chemically induced
Show abstract [+]

Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin.
Mehra A, Guérit S, Macrez R, Gosselet F, Sevin E, Lebas H, Maubert E, De Vries HE, Bardou I, Vivien D, Docagne F
J Neurosci 1529-2401
PMID : 31953371
KEYWORDS : Animals|Blood-Brain Barrier|drug effects|Cell Line|Cerebral Cortex|drug effects|Endothelial Cells|drug effects|Excitatory Amino Acid Agonists|pharmacology|Male|Mice|Myosins|metabolism|N-Methylaspartate|pharmacology|Neurons|drug effects|Permeability|Phosphorylation|drug effects|Receptors, N-Methyl-D-Aspartate|agonists|Signal Transduction|drug effects|Tissue Plasminogen Activator|pharmacology|Tumor Necrosis Factor-alpha|pharmacology|rho GTP-Binding Proteins|metabolism|rho-Associated Kinases|metabolism
Show abstract [+]

Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA).
Dupré N, Arabo A, Orset C, Maucotel J, Detroussel Y, Hauchecorne M, Gonzalez BJ, Marret S, Vivien D, Leroux P
Exp Neurol 1090-2430
PMID : 31697944
KEYWORDS : Animals|Animals, Newborn|Behavior, Animal|physiology|Blood-Brain Barrier|physiopathology|Capillary Permeability|physiology|Hypoxia-Ischemia, Brain|metabolism|Magnetic Resonance Imaging|Matrix Metalloproteinase 9|metabolism|Mice|Mice, Inbred C57BL|Mice, Knockout|Tissue Plasminogen Activator|metabolism
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Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors.
Anfray A, Drieu A, Hingot V, Hommet Y, Yetim M, Rubio M, Deffieux T, Tanter M, Orset C, Vivien D
J Cereb Blood Flow Metab 1559-7016
PMID : 31665952
KEYWORDS : Animals|Brain|diagnostic imaging|Cerebral Arteries|physiology|Cerebrovascular Circulation|physiology|Endothelium, Vascular|physiology|Immunohistochemistry|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|Neuroimaging|Neurovascular Coupling|physiology|Receptors, N-Methyl-D-Aspartate|physiology|Rheology|Tissue Plasminogen Activator|blood|Transfection|Ultrasonography
Show abstract [+]

Immune Responses and Anti-inflammatory Strategies in a Clinically Relevant Model of Thromboembolic Ischemic Stroke with Reperfusion.
Drieu A, Buendia I, Levard D, Hélie P, Brodin C, Vivien D, Rubio M
Transl Stroke Res 1868-601X
PMID : 31522409
KEYWORDS : Animals|Anti-Inflammatory Agents|administration & dosage|Brain|drug effects|Brain Ischemia|etiology|Disease Models, Animal|Ischemic Stroke|etiology|Male|Mice|Minocycline|administration & dosage|Natalizumab|administration & dosage|Reperfusion Injury|etiology|Thromboembolism|complications
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Glutamate controls vessel-associated migration of GABA interneurons from the pial migratory route via NMDA receptors and endothelial protease activation.
Léger C, Dupré N, Aligny C, Bénard M, Lebon A, Henry V, Hauchecorne M, Galas L, Frebourg T, Leroux P, Vivien D, Lecointre M, Marret S, Gonzalez BJ
Cell Mol Life Sci 1420-9071
PMID : 31392351
KEYWORDS : Animals|Animals, Newborn|Blood Vessels|metabolism|Brain Mapping|Cell Movement|genetics|Endothelial Cells|metabolism|GABAergic Neurons|metabolism|Gene Expression Regulation|genetics|Glutamate Decarboxylase|genetics|Glutamic Acid|genetics|Humans|Interneurons|metabolism|Matrix Metalloproteinase 9|genetics|Mice|Mice, Transgenic|Neurogenesis|genetics|Receptors, N-Methyl-D-Aspartate|genetics|Somatosensory Cortex|blood supply|Tissue Plasminogen Activator|genetics|gamma-Aminobutyric Acid|genetics
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2019


Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments.
Party H, Dujarrier C, Hébert M, Lenoir S, Martinez de Lizarrondo S, Delépée R, Fauchon C, Bouton MC, Obiang P, Godefroy O, Save E, Lecardeur L, Chabry J, Vivien D, Agin V
Acta Neuropathol Commun 2051-5960
PMID : 31610810
KEYWORDS : Animals|Brain|metabolism|Brain-Derived Neurotrophic Factor|metabolism|Depression|metabolism|Depressive Disorder, Major|metabolism|Disease Models, Animal|Dopamine|metabolism|Male|Mice, Inbred C57BL|Mice, Knockout|Plasminogen Activator Inhibitor 1|genetics|Serotonin|metabolism|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Longitudinal Molecular Magnetic Resonance Imaging of Endothelial Activation after Severe Traumatic Brain Injury.
Vegliante G, Tolomeo D, Drieu A, Rubio M, Micotti E, Moro F, Vivien D, Forloni G, Ali C, Zanier ER
J Clin Med 2077-0383
PMID : 31366109
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In vivo ultrasound-activated delivery of recombinant tissue plasminogen activator from the cavity of sub-micrometric capsules.
Correa-Paz C, Navarro Poupard MF, Polo E, Rodríguez-Pérez M, Taboada P, Iglesias-Rey R, Hervella P, Sobrino T, Vivien D, Castillo J, Del Pino P, Campos F, Pelaz B
J Control Release 1873-4995
PMID : 31310784
KEYWORDS : Administration, Intravenous|Animals|Brain Ischemia|drug therapy|Capsules|Drug Delivery Systems|Fibrinolytic Agents|administration & dosage|Male|Mice|Recombinant Proteins|Stroke|drug therapy|Tissue Plasminogen Activator|administration & dosage|Ultrasonic Waves
Show abstract [+]

Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time.
Kuhn E, Moulinet I, Perrotin A, La Joie R, Landeau B, Tomadesso C, Bejanin A, Sherif S, De La Sayette V, Desgranges B, Vivien D, Poisnel G, Chételat G
Alzheimers Res Ther 1758-9193
PMID : 31286994
KEYWORDS : Aged|Aged, 80 and over|Alzheimer Disease|diagnosis|Anxiety|diagnosis|Biomarkers|Cognitive Dysfunction|diagnosis|Cross-Sectional Studies|Depression|diagnosis|Diagnostic Self Evaluation|Disease Progression|Female|Follow-Up Studies|Gray Matter|diagnostic imaging|Humans|Longitudinal Studies|Magnetic Resonance Imaging|Male|Memory Disorders|diagnosis|Mental Status and Dementia Tests|Middle Aged|Neocortex|diagnostic imaging|Positron-Emission Tomography|Prodromal Symptoms
Show abstract [+]

Proteostasis During Cerebral Ischemia.
Thiebaut AM, Hedou E, Marciniak SJ, Vivien D, Roussel BD
Front Neurosci 1662-4548
PMID : 31275110
Show abstract [+]

HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy.
Couture A, Garnier A, Docagne F, Boyer O, Vivien D, Le-Mauff B, Latouche JB, Toutirais O
Front Immunol 1664-3224
PMID : 31156634
KEYWORDS : Antigen Presentation|Antigen-Presenting Cells|immunology|CD4-Positive T-Lymphocytes|immunology|Cancer Vaccines|immunology|Cell Proliferation|HLA Antigens|metabolism|Histocompatibility Antigens Class II|metabolism|Humans|Immunotherapy, Adoptive|methods|T-Lymphocytes, Regulatory|immunology
Show abstract [+]

Post-synaptic Release of the Neuronal Tissue-Type Plasminogen Activator (tPA).
Lenoir S, Varangot A, Lebouvier L, Galli T, Hommet Y, Vivien D
Front Cell Neurosci 1662-5102
PMID : 31105531
Show abstract [+]

Recent Advances in Nanomedicine for Ischemic and Hemorrhagic Stroke.
Bonnard T, Gauberti M, Martinez de Lizarrondo S, Campos F, Vivien D
Stroke 1524-4628
PMID : 30932782
KEYWORDS : Animals|Brain Ischemia|diagnosis|Humans|Intracranial Hemorrhages|diagnosis|Nanomedicine|methods|Stroke|diagnosis|Thrombolytic Therapy|methods

Tissue-Type Plasminogen Activator Controlled Corticogenesis Through a Mechanism Dependent of NMDA Receptors Expressed on Radial Glial Cells.
Pasquet N, Douceau S, Naveau M, Lesept F, Louessard M, Lebouvier L, Hommet Y, Vivien D, Bardou I
Cereb Cortex 1460-2199
PMID : 29878094
KEYWORDS : Animals|Cell Movement|physiology|Cerebral Cortex|embryology|Ependymoglial Cells|metabolism|Female|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|Neurogenesis|physiology|Neurons|physiology|Receptors, N-Methyl-D-Aspartate|metabolism|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Reduced spinal cord parenchymal cerebrospinal fluid circulation in experimental autoimmune encephalomyelitis.
Fournier AP, Gauberti M, Quenault A, Vivien D, Macrez R, Docagne F
J Cereb Blood Flow Metab 1559-7016
PMID : 29376456
KEYWORDS : Animals|Brain|physiopathology|Cerebrospinal Fluid|physiology|Cisterna Magna|drug effects|Contrast Media|administration & dosage|Encephalomyelitis, Autoimmune, Experimental|physiopathology|Female|Indocyanine Green|administration & dosage|Magnetic Resonance Imaging|Meglumine|administration & dosage|Mice|Multiple Sclerosis|physiopathology|Organometallic Compounds|administration & dosage|Parenchymal Tissue|physiopathology|Spinal Cord|physiopathology
Show abstract [+]

2018


The Age-Well observational study on expert meditators in the Medit-Ageing European project.
Lutz A, Klimecki OM, Collette F, Poisnel G, Arenaza-Urquijo E, Marchant NL, De La Sayette V, Rauchs G, Salmon E, Vuilleumier P, Frison E, Vivien D, Chételat G,
Alzheimers Dement (N Y) 2352-8737
PMID : 30662933
Show abstract [+]

The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD).
Marchant NL, Barnhofer T, Klimecki OM, Poisnel G, Lutz A, Arenaza-Urquijo E, Collette F, Wirth M, Schild AK, Coll-Padrós N, Reyrolle L, Horney D, Krolak-Salmon P, Molinuevo JL, Walker Z, Maillard A, Frison E, Jessen F, Chételat G,
Alzheimers Dement (N Y) 2352-8737
PMID : 30581979
Show abstract [+]

The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults.
Poisnel G, Arenaza-Urquijo E, Collette F, Klimecki OM, Marchant NL, Wirth M, de La Sayette V, Rauchs G, Salmon E, Vuilleumier P, Frison E, Maillard A, Vivien D, Lutz A, Chételat G,
Alzheimers Dement (N Y) 2352-8737
PMID : 30581977
Show abstract [+]

Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke.
Gauberti M, Lapergue B, Martinez de Lizarrondo S, Vivien D, Richard S, Bracard S, Piotin M, Gory B
Stroke 1524-4628
PMID : 30571423
KEYWORDS : Aged|Aged, 80 and over|Brain Ischemia|surgery|Diffusion Magnetic Resonance Imaging|Disease Progression|Endovascular Procedures|Female|Humans|Male|Middle Aged|Postoperative Complications|diagnostic imaging|Reperfusion Injury|diagnostic imaging|Stroke|surgery|Thrombectomy
Show abstract [+]

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond.
Thiebaut AM, Gauberti M, Ali C, Martinez De Lizarrondo S, Vivien D, Yepes M, Roussel BD
Lancet Neurol 1474-4465
PMID : 30507392
KEYWORDS : Animals|Fibrinolysis|drug effects|Humans|Stroke|therapy|Tissue Plasminogen Activator|pharmacology
Show abstract [+]

Cerebrospinal fluid leakage after posterior fossa surgery may impair brain metabolite clearance.
Goulay R, Aron Badin R, Flament J, Emery E, Hantraye P, Vivien D, Gaberel T
Neurochirurgie 1773-0619
PMID : 30477647
KEYWORDS : Animals|Brain|metabolism|Cerebrospinal Fluid|drug effects|Cerebrospinal Fluid Rhinorrhea|etiology|Gadolinium|therapeutic use|Glymphatic System|surgery|Humans|Primates
Show abstract [+]

A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis.
Vezain M, Lecuyer M, Rubio M, Dupé V, Ratié L, David V, Pasquier L, Odent S, Coutant S, Tournier I, Trestard L, Adle-Biassette H, Vivien D, Frébourg T, Gonzalez BJ, Laquerrière A, Saugier-Veber P
Acta Neuropathol Commun 2051-5960
PMID : 30340542
KEYWORDS : Adult|Animals|Cell Cycle|genetics|Cells, Cultured|Chick Embryo|DNA Mutational Analysis|Embryo, Mammalian|Female|Fetus|Gene Expression Regulation, Developmental|genetics|Gestational Age|Humans|Male|Mice|Mice, Inbred C57BL|Mice, Transgenic|Microcephaly|complications|Middle Aged|Mutation|genetics|Neuroglia|metabolism|Receptors, G-Protein-Coupled|genetics|Rhombencephalon|diagnostic imaging
Show abstract [+]

Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BclxL strategies through Mcl-1 down-regulation.
Bonnefond ML, Florent R, Lenoir S, Lambert B, Abeilard E, Giffard F, Louis MH, Elie N, Briand M, Vivien D, Poulain L, Gauduchon P, N'Diaye M
Oncotarget 1949-2553
PMID : 30338034
Show abstract [+]

Anti-inflammatory treatments for stroke: from bench to bedside.
Drieu A, Levard D, Vivien D, Rubio M
Ther Adv Neurol Disord 1756-2856
PMID : 30083232
Show abstract [+]

Cerebrospinal fluid flow increases from newborn to adult stages.
Di Palma C, Goulay R, Chagnot S, Martinez De Lizarrondo S, Anfray A, Salaun JP, Maubert E, Lechapt-Zalcman E, Andreiuolo F, Gakuba C, Emery E, Vivien D, Gauberti M, Gaberel T
Dev Neurobiol 1932-846X
PMID : 30027587
KEYWORDS : Adult|Animals|Animals, Newborn|cerebrospinal fluid|Biological Transport|physiology|Brain|metabolism|Cerebral Ventricles|physiology|Cerebrospinal Fluid|physiology|Humans|Magnetic Resonance Imaging|methods|Mice|Rats, Wistar
Show abstract [+]

Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke.
Gauberti M, Potzeha F, Vivien D, Martinez de Lizarrondo S
Front Med (Lausanne) 2296-858X
PMID : 30018956
Show abstract [+]

Erratum to: Molecular Magnetic Resonance Imaging (mMRI).
Gauberti M, Fournier AP, Vivien D, Martinez de Lizarrondo S
Methods Mol Biol 1940-6029
PMID : 29605882

Modification of apparent intracerebral hematoma volume on T2-weighted images during normobaric oxygen therapy may contribute to false diagnosis.
Goulay R, Drieu A, Di Palma C, Pro-Sistiaga P, Delcroix N, Chazalviel L, Saulnier R, Gakuba C, Goursaud S, Young AR, Gauberti M, Orset C, Emery E, Vivien D, Gaberel T
J Clin Neurosci 1532-2653
PMID : 29571939
KEYWORDS : Animals|Cerebral Hemorrhage|diagnostic imaging|Diagnostic Errors|Hematoma|diagnostic imaging|Magnetic Resonance Imaging|standards|Oxygen Inhalation Therapy|adverse effects|Swine
Show abstract [+]

Influence of on-going treatment with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker on the outcome of patients treated with intravenous rt-PA for ischemic stroke.
Gilliot S, Sibon I, Mas JL, Moulin T, Béjot Y, Cordonnier C, Giroud M, Odou P, Bordet R, Vivien D, Leys D,
J Neurol 1432-1459
PMID : 29549467
KEYWORDS : Administration, Intravenous|Aged|Aged, 80 and over|Angiotensin Receptor Antagonists|therapeutic use|Angiotensin-Converting Enzyme Inhibitors|therapeutic use|Brain Ischemia|complications|Female|Fibrinolytic Agents|therapeutic use|Follow-Up Studies|Humans|Intracranial Hemorrhages|complications|Male|Middle Aged|Prospective Studies|Recombinant Proteins|therapeutic use|Stroke|complications|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
Show abstract [+]

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.
Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A
Sci Transl Med 1946-6242
PMID : 29540615
KEYWORDS : Alarmins|metabolism|Animals|Atherosclerosis|metabolism|Brain|metabolism|Immunity, Innate|physiology|Inflammation|metabolism|Mice|Plaque, Atherosclerotic|metabolism|Stroke|metabolism
Show abstract [+]

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System.
Gauberti M, Fournier AP, Docagne F, Vivien D, Martinez de Lizarrondo S
Theranostics 1838-7640
PMID : 29507614
KEYWORDS : Animals|Central Nervous System|blood supply|Dextrans|chemistry|Endothelial Cells|metabolism|Humans|Magnetic Resonance Imaging|Magnetite Nanoparticles|chemistry|Molecular Imaging|Neurodegenerative Diseases|diagnostic imaging
Show abstract [+]

General Anesthesia Inhibits the Activity of the "Glymphatic System".
Gakuba C, Gaberel T, Goursaud S, Bourges J, Di Palma C, Quenault A, Martinez de Lizarrondo S, Vivien D, Gauberti M
Theranostics 1838-7640
PMID : 29344300
KEYWORDS : Anesthesia, General|adverse effects|Anesthetics, Inhalation|adverse effects|Animals|Contrast Media|pharmacokinetics|Fluorescent Dyes|pharmacokinetics|Glymphatic System|diagnostic imaging|Magnetic Resonance Imaging|methods|Male|Mice|Spectroscopy, Near-Infrared|methods
Show abstract [+]

Molecular Magnetic Resonance Imaging (mMRI).
Gauberti M, Fournier AP, Vivien D, Martinez de Lizarrondo S
Methods Mol Biol 1940-6029
PMID : 29341017
KEYWORDS : Animals|Brain|metabolism|Contrast Media|Ferric Compounds|chemistry|Magnetic Resonance Imaging|methods|Mice|Molecular Imaging|methods|Vascular Cell Adhesion Molecule-1|metabolism
Show abstract [+]

Worse Outcome in Stroke Patients Treated with rt-PA Without Early Reperfusion: Associated Factors.
Iglesias-Rey R, Rodríguez-Yáñez M, Rodríguez-Castro E, Pumar JM, Arias S, Santamaría M, López-Dequidt I, Hervella P, Correa-Paz C, Sobrino T, Vivien D, Campos F, Castellanos M, Castillo J
Transl Stroke Res 1868-601X
PMID : 29116527
KEYWORDS : Aged|Aged, 80 and over|Cohort Studies|Female|Fibrinolytic Agents|adverse effects|Hemorrhage|chemically induced|Humans|Male|Middle Aged|ROC Curve|Reperfusion|Stroke|drug therapy|Tissue Plasminogen Activator|adverse effects|Treatment Outcome
Show abstract [+]

Optimized tPA: A non-neurotoxic fibrinolytic agent for the drainage of intracerebral hemorrhages.
Goulay R, Naveau M, Gaberel T, Vivien D, Parcq J
J Cereb Blood Flow Metab 1559-7016
PMID : 28741405
KEYWORDS : Animals|Brain Edema|drug therapy|Cerebral Hemorrhage|drug therapy|Clinical Trials, Phase III as Topic|Disease Models, Animal|Drug Evaluation, Preclinical|Fibrinolytic Agents|pharmacology|Humans|Male|Mice|Protein Engineering|Recombinant Proteins|genetics|Swine|Tissue Plasminogen Activator|genetics
Show abstract [+]

Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery.
Quattromani MJ, Pruvost M, Guerreiro C, Backlund F, Englund E, Aspberg A, Jaworski T, Hakon J, Ruscher K, Kaczmarek L, Vivien D, Wieloch T
Mol Neurobiol 1559-1182
PMID : 28290150
KEYWORDS : Aged|Aged, 80 and over|Animals|Environment|Extracellular Matrix|metabolism|Female|Humans|Inflammation Mediators|metabolism|Male|Middle Aged|Neuronal Plasticity|physiology|Rats|Recovery of Function|physiology|Stroke|metabolism|Stroke Rehabilitation|methods
Show abstract [+]

2017


Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration.
Vaur P, Brugg B, Mericskay M, Li Z, Schmidt MS, Vivien D, Orset C, Jacotot E, Brenner C, Duplus E
FASEB J 1530-6860
PMID : 28842432
KEYWORDS : Animals|Axons|drug effects|Cell Death|drug effects|Cells, Cultured|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|N-Methylaspartate|pharmacology|Neurons|drug effects|Neuroprotective Agents|pharmacology|Niacinamide|analogs & derivatives|Real-Time Polymerase Chain Reaction
Show abstract [+]

Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain.
Lecuyer M, Rubio M, Chollat C, Lecointre M, Jégou S, Leroux P, Cleren C, Leroux-Nicollet I, Marpeau L, Vivien D, Marret S, Gonzalez BJ
Pharmacol Res Perspect 2052-1707
PMID : 28805973
Show abstract [+]

Can the benefits of rtPA treatment for stroke be improved?
Vivien D
Rev Neurol (Paris) 0035-3787
PMID : 28797689
KEYWORDS : Humans|Plasminogen Activators|therapeutic use|Stroke|drug therapy|Thrombectomy|Tissue Plasminogen Activator|therapeutic use
Show abstract [+]

The choroid plexus is a key cerebral invasion route for T cells after stroke.
Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A
Acta Neuropathol 1432-0533
PMID : 28762187
KEYWORDS : Aged|Aged, 80 and over|Animals|Brain Injuries, Traumatic|pathology|Brain Ischemia|pathology|Cell Movement|physiology|Cerebral Cortex|pathology|Chemokine CCL2|metabolism|Choroid Plexus|pathology|Disease Models, Animal|Female|Humans|Male|Mice, Inbred C57BL|Mice, Transgenic|Myeloid Cells|pathology|Stroke|pathology|T-Lymphocytes|pathology
Show abstract [+]

Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation.
Labeyrie PE, Goulay R, Martinez de Lizarrondo S, Hébert M, Gauberti M, Maubert E, Delaunay B, Gory B, Signorelli F, Turjman F, Touzé E, Courthéoux P, Vivien D, Orset C
Stroke 1524-4628
PMID : 28754830
KEYWORDS : Adult|Aneurysm, Ruptured|diagnostic imaging|Animals|Female|Fluorescent Antibody Technique|Humans|Immunohistochemistry|Intracranial Aneurysm|diagnostic imaging|Magnetic Resonance Imaging|Mice|Mice, Knockout|Plasminogen Activator Inhibitor 1|genetics|Rupture, Spontaneous|Tissue Plasminogen Activator|genetics
Show abstract [+]

Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death.
Louessard M, Bardou I, Lemarchand E, Thiebaut AM, Parcq J, Leprince J, Terrisse A, Carraro V, Fafournoux P, Bruhat A, Orset C, Vivien D, Ali C, Roussel BD
Cell Death Differ 1476-5403
PMID : 28644439
KEYWORDS : Activating Transcription Factor 4|metabolism|Animals|Apoptosis|drug effects|Cell Death|drug effects|Endoplasmic Reticulum Stress|drug effects|Fibrinolytic Agents|pharmacology|Heat-Shock Proteins|metabolism|Mice|Neurons|cytology|Protein-Serine-Threonine Kinases|metabolism|Signal Transduction|drug effects|Thromboembolism|therapy|Tissue Plasminogen Activator|pharmacology|Unfolded Protein Response|drug effects
Show abstract [+]

Are Distal and Proximal Visual Cues Equally Important during Spatial Learning in Mice? A Pilot Study of Overshadowing in the Spatial Domain.
Hébert M, Bulla J, Vivien D, Agin V
Front Behav Neurosci 1662-5153
PMID : 28634446
Show abstract [+]

Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin.
Fournier AP, Quenault A, Martinez de Lizarrondo S, Gauberti M, Defer G, Vivien D, Docagne F, Macrez R
Proc Natl Acad Sci U S A 1091-6490
PMID : 28533365
KEYWORDS : Animals|Blood-Brain Barrier|diagnostic imaging|Brain|pathology|Contrast Media|Disease Models, Animal|Disease Progression|Encephalomyelitis, Autoimmune, Experimental|pathology|Magnetic Resonance Imaging|methods|Male|Mice|Mice, Inbred C57BL|Multiple Sclerosis|diagnostic imaging|P-Selectin|metabolism|Recurrence|Spinal Cord|pathology
Show abstract [+]

Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate.
Goulay R, Flament J, Gauberti M, Naveau M, Pasquet N, Gakuba C, Emery E, Hantraye P, Vivien D, Aron-Badin R, Gaberel T
Stroke 1524-4628
PMID : 28526764
KEYWORDS : Animals|Brain|diagnostic imaging|Cerebrovascular Circulation|physiology|Macaca fascicularis|Male|Parenchymal Tissue|diagnostic imaging|Primates|Severity of Illness Index|Subarachnoid Hemorrhage|cerebrospinal fluid
Show abstract [+]

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi.
Martinez de Lizarrondo S, Gakuba C, Herbig BA, Repessé Y, Ali C, Denis CV, Lenting PJ, Touzé E, Diamond SL, Vivien D, Gauberti M
Circulation 1524-4539
PMID : 28487393
KEYWORDS : Acetylcysteine|pharmacology|Animals|Blood Platelets|cytology|Chlorides|toxicity|Disease Models, Animal|Ferric Compounds|toxicity|Fibrinolytic Agents|pharmacology|Infarction, Middle Cerebral Artery|drug therapy|Male|Mice|Platelet Aggregation|drug effects|Ristocetin|pharmacology|Thromboembolism|chemically induced|Thrombosis|prevention & control|Tissue Plasminogen Activator|therapeutic use|von Willebrand Factor|chemistry
Show abstract [+]

Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin.
Briens A, Bardou I, Lebas H, Miles LA, Parmer RJ, Vivien D, Docagne F
Cell Discov 2056-5968
PMID : 28417010
Show abstract [+]

Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination.
Leonetti C, Macrez R, Pruvost M, Hommet Y, Bronsard J, Fournier A, Perrigault M, Machin I, Vivien D, Clemente D, De Castro F, Maubert E, Docagne F
Mol Neurodegener 1750-1326
PMID : 28231842
KEYWORDS : Animals|Brain Injuries|pathology|Cell Differentiation|drug effects|Cell Movement|drug effects|Central Nervous System|drug effects|Corpus Callosum|drug effects|Embryo, Mammalian|Epidermal Growth Factor|Imaging, Three-Dimensional|Immunoblotting|Immunohistochemistry|Magnetic Resonance Imaging|Mice|Mice, Inbred C57BL|Mice, Knockout|Myelin Sheath|drug effects|Neural Stem Cells|cytology|Oligodendroglia|cytology|Tissue Plasminogen Activator|pharmacology|White Matter|drug effects
Show abstract [+]

ADAMTS-4 in central nervous system pathologies.
Lemarchant S, Wojciechowski S, Vivien D, Koistinaho J
J Neurosci Res 1097-4547
PMID : 28084617
KEYWORDS : ADAMTS4 Protein|Animals|Central Nervous System Diseases|metabolism|Humans
Show abstract [+]

Lack of collagen XV is protective after ischemic stroke in mice.
Dhungana H, Huuskonen MT, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen KM, Malm T, Koistinaho J, Lemarchant S
Cell Death Dis 2041-4889
PMID : 28079884
KEYWORDS : Animals|Brain Ischemia|genetics|Cerebral Cortex|metabolism|Collagen|genetics|Disease Models, Animal|Humans|Mice|Mice, Knockout|Neuroprotection|genetics|Stroke|genetics|Tissue Engineering|Tissue Plasminogen Activator|administration & dosage|Tissue Scaffolds|Vascular Endothelial Growth Factor A|genetics
Show abstract [+]

Recent progress in translational research on neurovascular and neurodegenerative disorders.
Demuth HU, Dijkhuizen RM, Farr TD, Gelderblom M, Horsburgh K, Iadecola C, Mcleod DD, Michalski D, Murphy TH, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Saur D, Savitz SI, Schilling S, Spratt NJ, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M, Boltze J,
Restor Neurol Neurosci 1878-3627
PMID : 28059802
KEYWORDS : Animals|Cerebrovascular Disorders|diagnosis|Humans|Neurodegenerative Diseases|diagnosis|Translational Medical Research
Show abstract [+]

Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack.
Quenault A, Martinez de Lizarrondo S, Etard O, Gauberti M, Orset C, Haelewyn B, Segal HC, Rothwell PM, Vivien D, Touzé E, Ali C
Brain 1460-2156
PMID : 28031221
KEYWORDS : Animals|Biomarkers|metabolism|Disease Models, Animal|Endothelial Cells|Ischemic Attack, Transient|diagnostic imaging|Magnetic Resonance Imaging|methods|Male|Mice|Molecular Imaging|methods|P-Selectin|metabolism|Stroke|diagnostic imaging
Show abstract [+]

F376A/M388A-solulin, a new promising antifibrinolytic for severe haemophilia A.
Parcq J, Petersen KU, Borel-Derlon A, Gautier P, Ebel M, Vivien D, Repessé Y
Haemophilia 1365-2516
PMID : 27928886
KEYWORDS : Factor VIII|therapeutic use|Fibrinolysis|physiology|Hemophilia A|drug therapy|Humans
Show abstract [+]

Distant Space Processing is Controlled by tPA-dependent NMDA Receptor Signaling in the Entorhinal Cortex.
Hébert M, Anfray A, Chevilley A, Martinez de Lizarrondo S, Quenault A, Louessard M, Roussel BD, Obiang P, Save E, Orset C, Maubert E, Vivien D, Agin V
Cereb Cortex 1460-2199
PMID : 27613436
KEYWORDS : Aging|Animals|Calcium|metabolism|Entorhinal Cortex|metabolism|Female|Hippocampus|metabolism|Male|Mice, Knockout|Neurons|metabolism|Receptors, N-Methyl-D-Aspartate|metabolism|Signal Transduction|physiology|Tissue Plasminogen Activator|deficiency
Show abstract [+]

2016


The "inflammatory penumbra" in ischemic stroke: From clinical data to experimental evidence.
Gauberti M, De Lizarrondo SM, Vivien D
Eur Stroke J 2396-9881
PMID : 31008264
Show abstract [+]

[Role of endothelial NMDA receptors in a mouse model of multiple sclerosis].
Macrez R, Vivien D, Docagne F
Med Sci (Paris) 1958-5381
PMID : 28044968
KEYWORDS : Animals|Antibodies, Monoclonal|therapeutic use|Blood-Brain Barrier|metabolism|Disease Models, Animal|Endothelium, Vascular|metabolism|Humans|Mice|Multiple Sclerosis|drug therapy|Receptors, N-Methyl-D-Aspartate|antagonists & inhibitors|Remission Induction

Retinal safety of intravitreal rtPA in healthy rats and under excitotoxic conditions.
Daruich A, Parcq J, Delaunay K, Naud MC, Le Rouzic Q, Picard E, Crisanti P, Vivien D, Berdugo M, Behar-Cohen F
Mol Vis 1090-0535
PMID : 27881907
KEYWORDS : Animals|Apoptosis|drug effects|Electroretinography|Intravitreal Injections|Male|Neurotoxins|toxicity|Rats, Long-Evans|Recombinant Proteins|administration & dosage|Retina|Retinal Ganglion Cells|drug effects|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors.
Lesept F, Chevilley A, Jezequel J, Ladépêche L, Macrez R, Aimable M, Lenoir S, Bertrand T, Rubrecht L, Galea P, Lebouvier L, Petersen KU, Hommet Y, Maubert E, Ali C, Groc L, Vivien D
Cell Death Dis 2041-4889
PMID : 27831563
KEYWORDS : Animals|Antibodies, Monoclonal|pharmacology|Calcium|metabolism|Cell Death|drug effects|Cell Membrane|drug effects|Diffusion|Fibrinolysin|pharmacology|HEK293 Cells|Humans|Lysine|metabolism|Male|Mice, Inbred BALB C|Neurons|cytology|Neurotoxins|toxicity|Protein Domains|Rats, Sprague-Dawley|Receptors, N-Methyl-D-Aspartate|chemistry|Signal Transduction|drug effects|Synapses|drug effects|Tissue Plasminogen Activator|pharmacology
Show abstract [+]

Proportion of single-chain recombinant tissue plasminogen activator and outcome after stroke.
Leys D, Hommet Y, Jacquet C, Moulin S, Sibon I, Mas JL, Moulin T, Giroud M, Sagnier S, Cordonnier C, Medeiros de Bustos E, Turc G, Ronzière T, Bejot Y, Detante O, Ouk T, Mendyk AM, Favrole P, Zuber M, Triquenot-Bagan A, Ozkul-Wermester O, Montoro FM, Lamy C, Faivre A, Lebouvier L, Potey C, Poli M, Hénon H, Renou P, Dequatre-Ponchelle N, Bodenant M, Debruxelles S, Rossi C, Bordet R, Vivien D,
Neurology 1526-632X
PMID : 27815401
KEYWORDS : Aged|Aged, 80 and over|Brain Ischemia|complications|Cerebral Hemorrhage|complications|Disability Evaluation|Female|Fibrinolytic Agents|chemistry|Humans|Male|Middle Aged|Recombinant Proteins|chemistry|Seizures|complications|Severity of Illness Index|Stroke|complications|Thrombolytic Therapy|Time-to-Treatment|Tissue Plasminogen Activator|chemistry|Treatment Outcome
Show abstract [+]

Valproic acid: a relevant thromboprophylactic strategy?
Martinez de Lizarrondo S, Gauberti M, Vivien D
J Thromb Haemost 1538-7836
PMID : 27709777
KEYWORDS : Humans|Valproic Acid

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities.
Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F
Lancet Neurol 1474-4465
PMID : 27571160
KEYWORDS : Biomarkers|metabolism|Excitatory Amino Acid Antagonists|therapeutic use|Glutamic Acid|metabolism|Humans|Multiple Sclerosis|drug therapy
Show abstract [+]

Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism.
Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I, Orset C, Pruvost M, Anfray A, Frigout Y, Hommet Y, Lebouvier L, Montaner J, Vivien D, Gauberti M
Blood 1528-0020
PMID : 27531677
KEYWORDS : Animals|Blood-Brain Barrier|drug effects|Bradykinin|metabolism|Bradykinin B2 Receptor Antagonists|pharmacology|Brain|drug effects|Capillary Permeability|drug effects|Fibrinolysin|metabolism|Fibrinolysis|drug effects|Hydrodynamics|Mice|Mice, Transgenic|Receptor, Bradykinin B2|genetics|Signal Transduction|drug effects|Tissue Plasminogen Activator|genetics
Show abstract [+]

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.
Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F
Brain 1460-2156
PMID : 27435092
KEYWORDS : Animals|Blood-Brain Barrier|metabolism|Encephalomyelitis, Autoimmune, Experimental|drug therapy|Endothelial Cells|Excitatory Amino Acid Antagonists|pharmacology|HEK293 Cells|Humans|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|Nerve Tissue Proteins|drug effects|Receptors, N-Methyl-D-Aspartate|drug effects|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis.
Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, El Amki M, Fatar M, Garcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D
Stroke 1524-4628
PMID : 27032444
KEYWORDS : Animals|Brain Ischemia|drug therapy|Disease Models, Animal|Fibrinolytic Agents|administration & dosage|Infarction, Middle Cerebral Artery|drug therapy|Male|Mice|Mice, Inbred C57BL|Stroke|drug therapy|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Nano-zymography Using Laser-Scanning Confocal Microscopy Unmasks Proteolytic Activity of Cell-Derived Microparticles.
Briens A, Gauberti M, Parcq J, Montaner J, Vivien D, Martinez de Lizarrondo S
Theranostics 1838-7640
PMID : 27022410
KEYWORDS : Animals|Cell-Derived Microparticles|chemistry|Disease Models, Animal|Humans|Mice|Microscopy, Confocal|methods|Peptide Hydrolases|analysis|Plasma|chemistry|Stroke|pathology
Show abstract [+]

Artificial antigen-presenting cells expressing HLA class II molecules as an effective tool for amplifying human specific memory CD4(+) T cells.
Garnier A, Hamieh M, Drouet A, Leprince J, Vivien D, Frébourg T, Le Mauff B, Latouche JB, Toutirais O
Immunol Cell Biol 1440-1711
PMID : 26924643
KEYWORDS : Animals|Antigen Presentation|immunology|Antigen-Presenting Cells|immunology|Artificial Cells|immunology|CD4-Positive T-Lymphocytes|cytology|Cell Proliferation|Epitopes|immunology|Histocompatibility Antigens Class II|metabolism|Humans|Immunologic Memory|Lymphocyte Activation|immunology|Mice|NIH 3T3 Cells|Peptides|metabolism|Phenotype|Tissue Donors
Show abstract [+]

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.
Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C
Brain Res 1872-6240
PMID : 26923166
KEYWORDS : Animals|Autophagy|Endoplasmic Reticulum Stress|physiology|Humans|Nervous System Diseases|complications|Proteasome Endopeptidase Complex|metabolism|Proteostasis Deficiencies|complications|Signal Transduction|Ubiquitin|metabolism|Unfolded Protein Response|physiology
Show abstract [+]

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.
Maysami S, Wong R, Pradillo JM, Denes A, Dhungana H, Malm T, Koistinaho J, Orset C, Rahman M, Rubio M, Schwaninger M, Vivien D, Bath PM, Rothwell NJ, Allan SM
J Cereb Blood Flow Metab 1559-7016
PMID : 26661169
KEYWORDS : Animals|Brain|drug effects|Brain Edema|complications|Brain Ischemia|complications|Disease Models, Animal|Drug Evaluation, Preclinical|Inflammation|complications|Interleukin 1 Receptor Antagonist Protein|therapeutic use|Male|Mice, Inbred BALB C|Mice, Inbred C57BL|Neuroprotective Agents|therapeutic use|Receptors, Interleukin-1|antagonists & inhibitors|Stroke|complications
Show abstract [+]

The story of an exceptional serine protease, tissue-type plasminogen activator (tPA).
Hébert M, Lesept F, Vivien D, Macrez R
Rev Neurol (Paris) 0035-3787
PMID : 26626577
KEYWORDS : Animals|Brain Chemistry|genetics|Humans|Serine Proteases|genetics|Tissue Plasminogen Activator|genetics
Show abstract [+]

The plasminogen activation system in neuroinflammation.
Mehra A, Ali C, Parcq J, Vivien D, Docagne F
Biochim Biophys Acta 0006-3002
PMID : 26493446
KEYWORDS : Animals|Blood-Brain Barrier|immunology|Central Nervous System Diseases|immunology|Fibrin|immunology|Fibrinolysin|immunology|Humans|Inflammation|immunology|Leukocytes|immunology|Microglia|immunology|Plasminogen|immunology|Tissue Plasminogen Activator|immunology
Show abstract [+]

Epidural Cortical Stimulation as a Treatment for Poststroke Aphasia: A Systematic Review of the Literature and Underlying Neurophysiological Mechanisms.
Balossier A, Etard O, Descat C, Vivien D, Emery E
Neurorehabil Neural Repair 1552-6844
PMID : 26422832
KEYWORDS : Aphasia, Broca|etiology|Cerebral Cortex|physiopathology|Electric Stimulation Therapy|methods|Humans|Stroke|complications
Show abstract [+]

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons.
Louessard M, Lacroix A, Martineau M, Mondielli G, Montagne A, Lesept F, Lambolez B, Cauli B, Mothet JP, Vivien D, Maubert E
Mol Neurobiol 1559-1182
PMID : 26377106
KEYWORDS : Animals|Cells, Cultured|Excitatory Postsynaptic Potentials|physiology|Gene Expression|Glutamic Acid|metabolism|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|Organ Culture Techniques|Pyramidal Cells|metabolism|Rats|Rats, Wistar|Synaptic Vesicles|metabolism|Tissue Plasminogen Activator|biosynthesis
Show abstract [+]

Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism.
Lemarchand E, Maubert E, Haelewyn B, Ali C, Rubio M, Vivien D
Cell Death Differ 1476-5403
PMID : 26068590
KEYWORDS : Animals|Brain Ischemia|genetics|Cell Death|genetics|Central Nervous System|metabolism|ErbB Receptors|genetics|Glucose|metabolism|Hippocampus|metabolism|Mice|Neurons|metabolism|Oxygen|metabolism|Rats|Signal Transduction|Tissue Plasminogen Activator|genetics
Show abstract [+]

Normalization of Reverse Transcription Quantitative PCR Data During Ageing in Distinct Cerebral Structures.
Bruckert G, Vivien D, Docagne F, Roussel BD
Mol Neurobiol 1559-1182
PMID : 25663136
KEYWORDS : Aging|genetics|Algorithms|Animals|Brain Chemistry|genetics|Cerebellum|metabolism|Cerebral Cortex|growth & development|Corpus Striatum|growth & development|Gene Expression Profiling|Hippocampus|metabolism|Male|Mice|Mice, Inbred C57BL|Nerve Tissue Proteins|biosynthesis|Reverse Transcriptase Polymerase Chain Reaction
Show abstract [+]

2015


Impacts of tissue-type plasminogen activator (tPA) on neuronal survival.
Chevilley A, Lesept F, Lenoir S, Ali C, Parcq J, Vivien D
Front Cell Neurosci 1662-5102
PMID : 26528141
Show abstract [+]

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
Bertrand T, Lesept F, Chevilley A, Lenoir S, Aimable M, Briens A, Hommet Y, Bardou I, Parcq J, Vivien D
Cell Death Dis 2041-4889
PMID : 26469972
KEYWORDS : Apoptosis|Calcium Signaling|Cell Survival|ErbB Receptors|metabolism|Female|Humans|Protein Conformation|Receptor Cross-Talk|Receptors, N-Methyl-D-Aspartate|metabolism|Tissue Plasminogen Activator|chemistry
Show abstract [+]

Unmasking Silent Endothelial Activation in the Cardiovascular System Using Molecular Magnetic Resonance Imaging.
Belliere J, Martinez de Lizarrondo S, Choudhury RP, Quenault A, Le Béhot A, Delage C, Chauveau D, Schanstra JP, Bascands JL, Vivien D, Gauberti M
Theranostics 1838-7640
PMID : 26379785
KEYWORDS : Animals|Cardiovascular Diseases|diagnosis|Cardiovascular System|pathology|Disease Models, Animal|Endothelium, Vascular|pathology|Magnetic Resonance Imaging|methods|Mice|Molecular Imaging|methods
Show abstract [+]

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.
Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A
Sci Transl Med 1946-6242
PMID : 26246166
KEYWORDS : Acute Disease|Animals|Antibodies, Monoclonal|therapeutic use|Brain Ischemia|drug therapy|Disease Models, Animal|Drug Evaluation, Preclinical|Humans|Integrin alpha4|immunology|Mice|Random Allocation|Treatment Outcome
Show abstract [+]

Letter by Macrez et al. Regarding Article, "Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke".
Macrez R, Vivien D, Docagne F
Stroke 1524-4628
PMID : 26022638
KEYWORDS : Autoantibodies|analysis|Brain Ischemia|pathology|Female|Humans|Male|Receptors, N-Methyl-D-Aspartate|immunology|Stroke|pathology

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator.
Lemarchand E, Gauberti M, Martinez de Lizarrondo S, Villain H, Repessé Y, Montagne A, Vivien D, Ali C, Rubio M
Stroke 1524-4628
PMID : 25922513
KEYWORDS : Alcohol Drinking|adverse effects|Animals|Brain Ischemia|drug therapy|Disease Models, Animal|Liver|metabolism|Low Density Lipoprotein Receptor-Related Protein-1|metabolism|Mice|Stroke|drug therapy|Thrombolytic Therapy|Tissue Plasminogen Activator|pharmacokinetics
Show abstract [+]

Letter by Gauberti and Vivien regarding article, "amplification of regulatory T cells using a CD28 superagonist reduces brain damage after ischemic stroke in mice".
Gauberti M, Vivien D
Stroke 1524-4628
PMID : 25586834
KEYWORDS : Animals|Brain|immunology|CD28 Antigens|agonists|Infarction, Middle Cerebral Artery|immunology|T-Lymphocytes, Regulatory|immunology

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke.
Wyseure T, Rubio M, Denorme F, Martinez de Lizarrondo S, Peeters M, Gils A, De Meyer SF, Vivien D, Declerck PJ
Blood 1528-0020
PMID : 25540192
KEYWORDS : Animals|Antibodies, Bispecific|chemistry|Disease Models, Animal|Female|Fibrinolytic Agents|therapeutic use|Histone Acetyltransferases|immunology|Immunotherapy|Male|Mice|Mice, Inbred C57BL|Protein Multimerization|Serpin E2|immunology|Stroke|pathology|TATA-Binding Protein Associated Factors|immunology|Therapies, Investigational|methods|Transcription Factor TFIID|immunology|Venous Thromboembolism|pathology
Show abstract [+]

NURR1 involvement in recombinant tissue-type plasminogen activator treatment complications after ischemic stroke.
Merino-Zamorano C, Hernández-Guillamon M, Jullienne A, Le Béhot A, Bardou I, Parés M, Fernández-Cadenas I, Giralt D, Carrera C, Ribó M, Vivien D, Ali C, Rosell A, Montaner J
Stroke 1524-4628
PMID : 25503547
KEYWORDS : Aged|Aged, 80 and over|Animals|Biomarkers|blood|Brain Ischemia|blood|Cell Line|Female|Fibrinolytic Agents|adverse effects|Humans|Inflammation|blood|Male|Mice|Middle Aged|Nuclear Receptor Subfamily 4, Group A, Member 2|biosynthesis|Stroke|blood|Tissue Plasminogen Activator|adverse effects|Treatment Outcome
Show abstract [+]

Understanding the functions of endogenous and exogenous tissue-type plasminogen activator during stroke.
Docagne F, Parcq J, Lijnen R, Ali C, Vivien D
Stroke 1524-4628
PMID : 25395410
KEYWORDS : Brain|physiology|Fibrinolytic Agents|therapeutic use|Humans|Stroke|drug therapy|Thrombolytic Therapy|Tissue Plasminogen Activator|physiology

BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes.
Ollitrault D, Legendre F, Drougard C, Briand M, Benateau H, Goux D, Chajra H, Poulain L, Hartmann D, Vivien D, Shridhar V, Baldi A, Mallein-Gerin F, Boumediene K, Demoor M, Galera P
Tissue Eng Part C Methods 1937-3392
PMID : 24957638
KEYWORDS : Aged|Aged, 80 and over|Animals|Bone Morphogenetic Protein 2|pharmacology|Cartilage, Articular|cytology|Cattle|Cell Hypoxia|drug effects|Cells, Cultured|Chondrocytes|Chondrogenesis|drug effects|Collagen Type I|metabolism|Extracellular Matrix|drug effects|High-Temperature Requirement A Serine Peptidase 1|Humans|Hyalin|metabolism|Hypertrophy|Kinetics|Mice, Nude|Middle Aged|Osteogenesis|drug effects|Phenotype|RNA, Messenger|genetics|RNA, Small Interfering|metabolism|Serine Endopeptidases|metabolism
Show abstract [+]

2014


Molecular magnetic resonance imaging of brain-immune interactions.
Gauberti M, Montagne A, Quenault A, Vivien D
Front Cell Neurosci 1662-5102
PMID : 25505871
Show abstract [+]

Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis?
Gaberel T, Gakuba C, Goulay R, Martinez De Lizarrondo S, Hanouz JL, Emery E, Touze E, Vivien D, Gauberti M
Stroke 1524-4628
PMID : 25190438
KEYWORDS : Animals|Cerebrospinal Fluid|physiology|Contrast Media|Disease Models, Animal|Image Interpretation, Computer-Assisted|Magnetic Resonance Imaging|methods|Mice|Stroke|cerebrospinal fluid|Subarachnoid Hemorrhage|cerebrospinal fluid
Show abstract [+]

Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis.
Gaberel T, Montagne A, Lesept F, Gauberti M, Lemarchand E, Orset C, Goulay R, Bertrand T, Emery E, Vivien D
Neuropharmacology 1873-7064
PMID : 24846802
KEYWORDS : Animals|Brain|drug effects|Brain Edema|drug therapy|Cells, Cultured|Cerebral Hemorrhage|drug therapy|Collagenases|Disease Models, Animal|Fibrinolysis|drug effects|Fibrinolytic Agents|pharmacology|Hematoma|drug therapy|Hydrocephalus|drug therapy|Male|Mice|Neuroimmunomodulation|drug effects|Random Allocation|Rats, Sprague-Dawley|Recovery of Function|drug effects|Tissue Plasminogen Activator|pharmacology|Urokinase-Type Plasminogen Activator|pharmacology
Show abstract [+]

GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.
Le Behot A, Gauberti M, Martinez De Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, Guillou S, Denis CV, Maubert E, Orset C, Vivien D
Blood 1528-0020
PMID : 24553181
KEYWORDS : Animals|Benzofurans|Blood Platelets|metabolism|Blood Vessels|metabolism|Hemorheology|Male|Mice|Platelet Aggregation|Platelet Glycoprotein GPIb-IX Complex|metabolism|Protein Interaction Maps|Quinolines|Thrombosis|metabolism|von Willebrand Factor|metabolism
Show abstract [+]

Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.
Gauberti M, Martinez de Lizarrondo S, Orset C, Vivien D
J Thromb Haemost 1538-7836
PMID : 24354644
KEYWORDS : Animals|Blood Coagulation|Bradykinin|metabolism|Brain Diseases|prevention & control|Cerebrovascular Circulation|Factor XII|metabolism|Inflammation|Ischemia|pathology|Macaca mulatta|Male|Mice|Mice, Inbred C57BL|Stroke|chemically induced|T-Lymphocytes|cytology|Thrombin|adverse effects|Thrombosis|pathology|von Willebrand Factor|metabolism
Show abstract [+]

2013


Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.
Gaberel T, Gakuba C, Hebert M, Montagne A, Agin V, Rubio M, Emery E, Vivien D, Gauberti M
Stroke 1524-4628
PMID : 24105700
KEYWORDS : Animals|Brain|pathology|Intracranial Hemorrhages|blood|Magnetic Resonance Imaging|Mice|Oxygen|blood|Oxygen Inhalation Therapy|Treatment Outcome
Show abstract [+]

Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes.
Gauberti M, Montagne A, Marcos-Contreras OA, Le Béhot A, Maubert E, Vivien D
Stroke 1524-4628
PMID : 23743972
KEYWORDS : Animals|Ferric Compounds|Image Enhancement|methods|Infarction, Middle Cerebral Artery|drug therapy|Inflammation|drug therapy|Intracranial Hemorrhages|chemically induced|Magnetic Resonance Imaging|instrumentation|Mice|Vascular Cell Adhesion Molecule-1|drug effects
Show abstract [+]

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome.
Gaberel T, Macrez R, Gauberti M, Montagne A, Hebert M, Petersen KU, Touze E, Agin V, Emery E, Ali C, Vivien D
Neuropharmacology 1873-7064
PMID : 23219658
KEYWORDS : Animals|Antibodies, Monoclonal, Murine-Derived|administration & dosage|Immunotherapy|methods|Intracranial Hemorrhages|immunology|Male|Mice|Random Allocation|Rats|Rats, Sprague-Dawley|Receptors, N-Methyl-D-Aspartate|metabolism|Stroke|immunology|Tissue Plasminogen Activator|antagonists & inhibitors|Treatment Outcome
Show abstract [+]

Epidural electrical stimulation for the treatment of chronic poststroke aphasia: still compulsory 6 years later!
Balossier A, Etard O, Descat C, Vivien D, Emery E
Br J Neurosurg 1360-046X
PMID : 22998751
KEYWORDS : Aphasia, Broca|etiology|Electric Stimulation Therapy|methods|Electrodes, Implanted|Female|Humans|Middle Aged|Stroke|complications
Show abstract [+]

2012


GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory.
Obiang P, Macrez R, Jullienne A, Bertrand T, Lesept F, Ali C, Maubert E, Vivien D, Agin V
J Neurosci 1529-2401
PMID : 22972996
KEYWORDS : Animals|Glutamic Acid|metabolism|Male|Maze Learning|physiology|Memory, Short-Term|physiology|Mice|Mice, Knockout|Mice, Transgenic|Protein Subunits|Receptors, N-Methyl-D-Aspartate|metabolism|Space Perception|physiology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Memantine improves safety of thrombolysis for stroke.
Montagne A, Hébert M, Jullienne A, Lesept F, Le Béhot A, Louessard M, Gauberti M, Orset C, Ali C, Agin V, Maubert E, Vivien D
Stroke 1524-4628
PMID : 22879098
KEYWORDS : Animals|Cells, Cultured|Cerebral Cortex|drug effects|Chemotherapy, Adjuvant|Excitatory Amino Acid Antagonists|pharmacology|Fibrinolytic Agents|adverse effects|In Vitro Techniques|Magnetic Resonance Imaging|Male|Memantine|pharmacology|Mice|Models, Animal|N-Methylaspartate|pharmacology|Stroke|drug therapy|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|adverse effects|Treatment Outcome
Show abstract [+]

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders.
Montagne A, Gauberti M, Macrez R, Jullienne A, Briens A, Raynaud JS, Louin G, Buisson A, Haelewyn B, Docagne F, Defer G, Vivien D, Maubert E
Neuroimage 1095-9572
PMID : 22813950
KEYWORDS : Animals|Blotting, Western|Central Nervous System Diseases|diagnosis|Endothelial Cells|metabolism|Ferric Compounds|Immunohistochemistry|Magnetic Resonance Imaging|methods|Male|Metal Nanoparticles|Mice|Mice, Inbred C57BL|Molecular Imaging|methods|Real-Time Polymerase Chain Reaction|Reverse Transcriptase Polymerase Chain Reaction
Show abstract [+]

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.
Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E, Vivien D
Cell Death Differ 1476-5403
PMID : 22743997
KEYWORDS : Animals|Calcium|metabolism|Cells, Cultured|Humans|Mice|Mitogen-Activated Protein Kinase 1|metabolism|Mitogen-Activated Protein Kinase 3|metabolism|N-Methylaspartate|toxicity|Neurons|drug effects|Receptors, N-Methyl-D-Aspartate|metabolism|Recombinant Proteins|genetics|Signal Transduction|drug effects|Tissue Plasminogen Activator|genetics
Show abstract [+]

tPA in the injured central nervous system: different scenarios starring the same actor?
Lemarchant S, Docagne F, Emery E, Vivien D, Ali C, Rubio M
Neuropharmacology 1873-7064
PMID : 22079561
KEYWORDS : Brain Ischemia|metabolism|Central Nervous System|metabolism|Humans|Multiple Sclerosis|metabolism|Spinal Cord Injuries|metabolism|Stroke|metabolism|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Epidural electrical stimulation to improve chronic poststroke aphasia: a 5-year follow-up.
Balossier A, Etard O, Descat C, Vivien D, Emery E
Brain Stimul 1876-4754
PMID : 22037142
KEYWORDS : Aphasia|etiology|Electric Stimulation Therapy|methods|Epidural Space|Female|Follow-Up Studies|Humans|Middle Aged|Stroke|complications|Stroke Rehabilitation|Treatment Outcome
Show abstract [+]

2011


Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo.
Jullienne A, Montagne A, Orset C, Lesept F, Jane DE, Monaghan DT, Maubert E, Vivien D, Ali C
Mol Neurodegener 1750-1326
PMID : 21975018
Show abstract [+]

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.
Rubio M, Villain H, Docagne F, Roussel BD, Ramos JA, Vivien D, Fernandez-Ruiz J, Ali C
PLoS One 1932-6203
PMID : 21886913
KEYWORDS : Animals|Cannabinoids|agonists|Cell Death|drug effects|Cells, Cultured|Ethanol|pharmacology|Excitatory Amino Acid Agonists|pharmacology|Mice|N-Methylaspartate|analysis|Neurons|Neuroprotective Agents|Piperidines|pharmacology|Pyrazoles|pharmacology|Receptor, Cannabinoid, CB1|antagonists & inhibitors|Rimonabant|Substance Withdrawal Syndrome
Show abstract [+]

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.
Vivien D, Gauberti M, Montagne A, Defer G, Touzé E
J Cereb Blood Flow Metab 1559-7016
PMID : 21878948
KEYWORDS : Acute Disease|Aging|pathology|Animals|Blood-Brain Barrier|drug effects|Brain|blood supply|Drug Administration Schedule|Fibrinolytic Agents|administration & dosage|Humans|Microvessels|drug effects|Stroke|drug therapy|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Intraventricular fibrinolysis versus external ventricular drainage alone in intraventricular hemorrhage: a meta-analysis.
Gaberel T, Magheru C, Parienti JJ, Huttner HB, Vivien D, Emery E
Stroke 1524-4628
PMID : 21817146
KEYWORDS : Cerebral Hemorrhage|drug therapy|Cerebral Ventricles|surgery|Drainage|methods|Fibrinolytic Agents|therapeutic use|Humans|Injections, Intraventricular|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
Show abstract [+]

Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation.
Gakuba C, Gauberti M, Mazighi M, Defer G, Hanouz JL, Vivien D
Stroke 1524-4628
PMID : 21817137
KEYWORDS : Anesthetics, Dissociative|therapeutic use|Animals|Brain Ischemia|drug therapy|Fibrinolytic Agents|therapeutic use|Ketamine|therapeutic use|Magnetic Resonance Imaging|Male|Mice|Stroke|drug therapy|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
Show abstract [+]

Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis.
Macrez R, Obiang P, Gauberti M, Roussel B, Baron A, Parcq J, Cassé F, Hommet Y, Orset C, Agin V, Bezin L, Berrocoso TG, Petersen KU, Montaner J, Maubert E, Vivien D, Ali C
Stroke 1524-4628
PMID : 21680906
KEYWORDS : Animals|Antibodies|immunology|Brain|drug effects|Brain Ischemia|drug therapy|Fibrinolytic Agents|immunology|Mice|Receptors, N-Methyl-D-Aspartate|immunology|Stroke|drug therapy|Tissue Plasminogen Activator|immunology
Show abstract [+]

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator.
Roussel BD, Mysiorek C, Rouhiainen A, Jullienne A, Parcq J, Hommet Y, Culot M, Berezowski V, Cecchelli R, Rauvala H, Vivien D, Ali C
J Cell Sci 1477-9137
PMID : 21610098
KEYWORDS : Animals|Biomarkers|blood|Blood-Brain Barrier|cytology|Calcium|metabolism|Cattle|Cells, Cultured|Coculture Techniques|Fibrinolysis|drug effects|HMG-Box Domains|HMGB1 Protein|metabolism|Humans|Mice|N-Methylaspartate|pharmacology|Neurons|drug effects|Neuroprotective Agents|pharmacology|Rats|Rats, Sprague-Dawley|Recombinant Proteins|pharmacology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Tissue plasminogen activator prevents white matter damage following stroke.
Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P, Hernangómez M, Montagne A, Liot G, Guaza C, Maubert E, Ali C, Vivien D, Docagne F
J Exp Med 1540-9538
PMID : 21576385
KEYWORDS : Aging|Animals|Apoptosis|Brain|pathology|Brain Injuries|pathology|Caspase 3|metabolism|Cell Lineage|Cytokines|metabolism|Endothelium, Vascular|cytology|Epidermal Growth Factor|chemistry|Extracellular Signal-Regulated MAP Kinases|metabolism|Humans|Mice|Mice, Inbred C57BL|Oligodendroglia|cytology|Stroke|pathology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Stroke and the immune system: from pathophysiology to new therapeutic strategies.
Macrez R, Ali C, Toutirais O, Le Mauff B, Defer G, Dirnagl U, Vivien D
Lancet Neurol 1474-4465
PMID : 21511199
KEYWORDS : Animals|Brain|drug effects|Brain Diseases|immunology|Humans|Immunologic Factors|therapeutic use|Stroke|immunology
Show abstract [+]

Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF.
Obiang P, Maubert E, Bardou I, Nicole O, Launay S, Bezin L, Vivien D, Agin V
Neurobiol Learn Mem 1095-9564
PMID : 21440650
KEYWORDS : Aging|physiology|Animals|Association Learning|physiology|Behavior, Animal|physiology|Brain|physiology|Brain-Derived Neurotrophic Factor|metabolism|Conditioning, Psychological|physiology|Environment|Fear|physiology|Female|Housing, Animal|Memory|physiology|Mice|Neurons|physiology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

2010


Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke.
Macrez R, Bezin L, Le Mauff B, Ali C, Vivien D
Stroke 1524-4628
PMID : 20966414
KEYWORDS : Animals|Autoantibodies|biosynthesis|Immunization|Immunohistochemistry|Mice|Nerve Tissue Proteins|biosynthesis|Receptors, N-Methyl-D-Aspartate|genetics|Recombinant Proteins|biosynthesis|Stroke|drug therapy|Thrombin|pharmacology|Thrombolytic Therapy|Tissue Plasminogen Activator|immunology
Show abstract [+]

Plasmin on adherent cells: from microvesiculation to apoptosis.
Doeuvre L, Plawinski L, Goux D, Vivien D, Anglés-Cano E
Biochem J 1470-8728
PMID : 20846121
KEYWORDS : Animals|Apoptosis|Blood Platelets|cytology|Blotting, Western|CHO Cells|Cell Adhesion|physiology|Cell Survival|physiology|Cricetinae|Cricetulus|Fibrinolysin|biosynthesis|Humans|In Situ Nick-End Labeling|Kinetics|Microscopy, Electron|Plasminogen|chemistry|Tissue Plasminogen Activator|physiology
Show abstract [+]

Tissue-type plasminogen activator induces plasmin-dependent proteolysis of intracellular neuronal nitric oxide synthase.
Baron A, Hommet Y, Cassé F, Vivien D
Biol Cell 1768-322X
PMID : 20636282
KEYWORDS : Animals|Fibrinolysin|metabolism|Mice|N-Methylaspartate|metabolism|Neurons|enzymology|Nitric Oxide Synthase Type I|metabolism|Signal Transduction|Tissue Plasminogen Activator|metabolism
Show abstract [+]

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
Baron A, Montagne A, Cassé F, Launay S, Maubert E, Ali C, Vivien D
Cell Death Differ 1476-5403
PMID : 19911010
KEYWORDS : Animals|Cells, Cultured|Diazonium Compounds|pharmacology|Fibrinolytic Agents|pharmacology|Immunoblotting|Immunohistochemistry|Mice|Neurons|drug effects|Potassium Chloride|pharmacology|Pyridines|pharmacology|RNA Interference|Receptors, N-Methyl-D-Aspartate|genetics|Reverse Transcriptase Polymerase Chain Reaction|Tissue Plasminogen Activator|pharmacology
Show abstract [+]

2009


[Cerebral ischemia (2), How to neutralize the neurotoxic effects of tPA].
Vivien D, Gauberti M, Guedin P, Anglés-Cano E,
Med Sci (Paris) 0767-0974
PMID : 19849989
KEYWORDS : Amino Acid Sequence|Blood-Brain Barrier|Brain Ischemia|drug therapy|Humans|Molecular Sequence Data|Neurotoxins|toxicity|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|chemistry

[Cellular microparticles, potential useful biomarkers in the identification of cerebrovascular accidents].
Anglés-Cano E, Vivien D,
Med Sci (Paris) 0767-0974
PMID : 19849987
KEYWORDS : Biomarkers|blood|Blood Coagulation|Cell-Derived Microparticles|metabolism|Fibrinolysis|Humans|Metalloproteases|blood|Stroke|blood
Show abstract [+]

Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Roussel BD, Macrez R, Jullienne A, Agin V, Maubert E, Dauphinot L, Potier MC, Plawinski L, Castel H, Hommet Y, Munuera J, Montaner J, Yepes M, Ali C, Vivien D
Brain 1460-2156
PMID : 19574439
KEYWORDS : Aged|Aged, 80 and over|Aging|metabolism|Animals|Brain|metabolism|Brain Ischemia|metabolism|Cell Death|drug effects|DNA-Binding Proteins|genetics|Disease Models, Animal|Female|Gene Knockdown Techniques|methods|Humans|Magnetic Resonance Imaging|methods|Mice|Mice, Inbred C57BL|Middle Aged|N-Methylaspartate|toxicity|Neurons|drug effects|Reverse Transcriptase Polymerase Chain Reaction|methods|Tissue Plasminogen Activator|metabolism|Transcription Factors|genetics
Show abstract [+]

Distribution of oxytocin-like and vasopressin-like immunoreactivities within the central nervous system of the cuttlefish, Sepia officinalis.
Bardou I, Maubert E, Leprince J, Chichery R, Cocquerelle C, Launay S, Vivien D, Vaudry H, Agin V
Cell Tissue Res 1432-0878
PMID : 19259702
KEYWORDS : Amino Acid Sequence|Animals|Central Nervous System|anatomy & histology|Mice|Molecular Sequence Data|Nerve Fibers|metabolism|Oxytocin|chemistry|Sepia|metabolism|Vasopressins|chemistry
Show abstract [+]

2008


HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.
Launay S, Maubert E, Lebeurrier N, Tennstaedt A, Campioni M, Docagne F, Gabriel C, Dauphinot L, Potier MC, Ehrmann M, Baldi A, Vivien D
Cell Death Differ 1350-9047
PMID : 18551132
KEYWORDS : Animals|Brain|embryology|Cell Survival|Cells, Cultured|High-Temperature Requirement A Serine Peptidase 1|Mice|Mice, Transgenic|Neurons|cytology|Serine Endopeptidases|metabolism|Signal Transduction|Transforming Growth Factor beta1|metabolism|Up-Regulation
Show abstract [+]

Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity.
Lopez-Atalaya JP, Roussel BD, Levrat D, Parcq J, Nicole O, Hommet Y, Benchenane K, Castel H, Leprince J, To Van D, Bureau R, Rault S, Vaudry H, Petersen KU, Santos JS, Ali C, Vivien D
J Cereb Blood Flow Metab 0271-678X
PMID : 18334994
KEYWORDS : Amino Acid Sequence|Animals|Catalytic Domain|Cells, Cultured|Drug-Related Side Effects and Adverse Reactions|Fibrinolytic Agents|toxicity|Mice|Models, Molecular|Molecular Sequence Data|Neurons|drug effects|Plasminogen Activators|metabolism|Protein Binding|Protein Structure, Quaternary|Receptors, N-Methyl-D-Aspartate|chemistry|Signal Transduction|Stroke|metabolism|Tissue Culture Techniques|Tissue Plasminogen Activator|chemistry
Show abstract [+]

2007


Neuroprotection and stroke: time for a compromise.
Young AR, Ali C, Duretête A, Vivien D
J Neurochem 1471-4159
PMID : 17727635
KEYWORDS : Animals|Clinical Trials as Topic|trends|Humans|Neuroprotective Agents|therapeutic use|Stroke|drug therapy|Thrombolytic Therapy|methods
Show abstract [+]

Mouse model of in situ thromboembolic stroke and reperfusion.
Orset C, Macrez R, Young AR, Panthou D, Angles-Cano E, Maubert E, Agin V, Vivien D
Stroke 1524-4628
PMID : 17702959
KEYWORDS : Animals|Cerebral Infarction|chemically induced|Cerebrovascular Circulation|drug effects|Disease Models, Animal|Fibrinolytic Agents|pharmacology|Intracranial Embolism|chemically induced|Laser-Doppler Flowmetry|Male|Mice|Motor Activity|Reperfusion|Reproducibility of Results|Thrombin|Tissue Plasminogen Activator|pharmacology
Show abstract [+]

Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms.
Cacquevel M, Launay S, Castel H, Benchenane K, Chéenne S, Buée L, Moons L, Delacourte A, Carmeliet P, Vivien D
Neurobiol Dis 0969-9961
PMID : 17566751
KEYWORDS : Aging|physiology|Alzheimer Disease|enzymology|Amyloid beta-Peptides|metabolism|Animals|Brain|enzymology|Enzyme-Linked Immunosorbent Assay|Humans|Immunohistochemistry|Mice|Mice, Transgenic|RNA, Messenger|analysis|Reverse Transcriptase Polymerase Chain Reaction|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects.
López-Atalaya JP, Roussel BD, Ali C, Maubert E, Petersen KU, Berezowski V, Cecchelli R, Orset C, Vivien D
Stroke 1524-4628
PMID : 17325305
KEYWORDS : Animals|Blood-Brain Barrier|drug effects|Cattle|Cells, Cultured|Chiroptera|Coculture Techniques|Fibrinolytic Agents|pharmacokinetics|Humans|Low Density Lipoprotein Receptor-Related Protein-1|physiology|Male|Plasminogen Activators|pharmacokinetics|Rats|Rats, Sprague-Dawley|Recombinant Proteins|pharmacokinetics
Show abstract [+]

Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory.
Benchenane K, Castel H, Boulouard M, Bluthé R, Fernandez-Monreal M, Roussel BD, Lopez-Atalaya JP, Butt-Gueulle S, Agin V, Maubert E, Dantzer R, Touzani O, Dauphin F, Vivien D, Ali C
J Cell Sci 0021-9533
PMID : 17244650
KEYWORDS : Animals|Behavior, Animal|drug effects|Excitatory Amino Acid Agonists|pharmacology|Female|Maze Learning|drug effects|Memory|drug effects|Mice|Models, Immunological|N-Methylaspartate|pharmacology|Protein Structure, Tertiary|Receptors, N-Methyl-D-Aspartate|chemistry|Tissue Plasminogen Activator|deficiency|Vaccination
Show abstract [+]

2005


The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.
Lebeurrier N, Liot G, Lopez-Atalaya JP, Orset C, Fernandez-Monreal M, Sonderegger P, Ali C, Vivien D
Mol Cell Neurosci 1044-7431
PMID : 16209928
KEYWORDS : Animals|Apoptosis|drug effects|Brain|drug effects|Brain Ischemia|drug therapy|Calcium Signaling|drug effects|Cells, Cultured|Cerebral Cortex|drug effects|Corpus Striatum|drug effects|Disease Models, Animal|Male|Mice|N-Methylaspartate|antagonists & inhibitors|Neurons|drug effects|Neuropeptides|metabolism|Neuroprotective Agents|metabolism|Neurotoxins|antagonists & inhibitors|Receptors, N-Methyl-D-Aspartate|drug effects|Serpins|metabolism|Stroke|metabolism
Show abstract [+]

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis.
Benchenane K, Berezowski V, Ali C, Fernández-Monreal M, López-Atalaya JP, Brillault J, Chuquet J, Nouvelot A, MacKenzie ET, Bu G, Cecchelli R, Touzani O, Vivien D
Circulation 1524-4539
PMID : 15851587
KEYWORDS : Animals|Blood-Brain Barrier|metabolism|Brain|drug effects|Cold Temperature|Low Density Lipoprotein Receptor-Related Protein-1|metabolism|Male|N-Methylaspartate|administration & dosage|Neurotoxicity Syndromes|etiology|Plasminogen Activator Inhibitor 1|administration & dosage|Protein Transport|Rats|Rats, Sprague-Dawley|Tissue Plasminogen Activator|adverse effects
Show abstract [+]

Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process.
Benchenane K, Berezowski V, Fernández-Monreal M, Brillault J, Valable S, Dehouck MP, Cecchelli R, Vivien D, Touzani O, Ali C
Stroke 1524-4628
PMID : 15817895
KEYWORDS : Animals|Blood-Brain Barrier|metabolism|Brain Ischemia|etiology|Cell Hypoxia|Cytoplasmic Vesicles|chemistry|Endothelium, Vascular|cytology|Glucose|physiology|Infarction, Middle Cerebral Artery|complications|LDL-Receptor Related Proteins|antagonists & inhibitors|Male|Mice|Protein Transport|Tissue Plasminogen Activator|analysis
Show abstract [+]

2004


2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo.
Liot G, Benchenane K, Léveillé F, López-Atalaya JP, Fernández-Monreal M, Ruocco A, Mackenzie ET, Buisson A, Ali C, Vivien D
J Cereb Blood Flow Metab 0271-678X
PMID : 15529015
KEYWORDS : Animals|Brain Ischemia|drug therapy|Cell Death|drug effects|Cells, Cultured|Cycloheptanes|Excitatory Amino Acid Agonists|toxicity|In Vitro Techniques|Male|Mice|N-Methylaspartate|toxicity|Neurons|cytology|Neurotoxins|toxicity|Rats|Rats, Sprague-Dawley|Serine Proteinase Inhibitors|pharmacology|Signal Transduction|drug effects|Tissue Plasminogen Activator|antagonists & inhibitors
Show abstract [+]

Cytokines in neuroinflammation and Alzheimer's disease.
Cacquevel M, Lebeurrier N, Chéenne S, Vivien D
Curr Drug Targets 1389-4501
PMID : 15270199
KEYWORDS : Alzheimer Disease|metabolism|Brain|cytology|Cytokines|chemistry|Humans|Inflammation|metabolism|Models, Biological|Transforming Growth Factor beta|chemistry
Show abstract [+]

The complexity of tissue-type plasminogen activator: can serine protease inhibitors help in stroke management?
Lebeurrier N, Vivien D, Ali C
Expert Opin Ther Targets 1744-7631
PMID : 15268626
KEYWORDS : Animals|Disease Management|Humans|Serine Proteinase Inhibitors|administration & dosage|Stroke|drug therapy|Time Factors|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis.
Liot G, Gabriel C, Cacquevel M, Ali C, MacKenzie ET, Buisson A, Vivien D
Exp Neurol 0014-4886
PMID : 15081586
KEYWORDS : Animals|Apoptosis|drug effects|Cells, Cultured|Cerebral Cortex|cytology|Culture Media, Serum-Free|pharmacology|Enzyme Inhibitors|pharmacology|MAP Kinase Signaling System|drug effects|Mice|Neurons|cytology|Neuroprotective Agents|pharmacology|Neurotrophin 3|pharmacology|Phosphatidylinositol 3-Kinases|metabolism|Phosphoinositide-3 Kinase Inhibitors|Protein-Serine-Threonine Kinases|Proto-Oncogene Proteins|metabolism|Proto-Oncogene Proteins c-akt|Signal Transduction|drug effects
Show abstract [+]

Equivocal roles of tissue-type plasminogen activator in stroke-induced injury.
Benchenane K, López-Atalaya JP, Fernández-Monreal M, Touzani O, Vivien D
Trends Neurosci 0166-2236
PMID : 15036881
KEYWORDS : Animals|Cell Death|drug effects|Disease Models, Animal|Fibrinolytic Agents|adverse effects|Glutamic Acid|metabolism|Humans|Neuroglia|drug effects|Neurons|drug effects|Neuroprotective Agents|adverse effects|Signal Transduction|drug effects|Stroke|complications|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|adverse effects|Transforming Growth Factor beta|therapeutic use|Transforming Growth Factor beta1
Show abstract [+]

2003


Transforming growth factor-beta and ischemic brain injury.
Buisson A, Lesne S, Docagne F, Ali C, Nicole O, MacKenzie ET, Vivien D
Cell Mol Neurobiol 0272-4340
PMID : 14514014
KEYWORDS : Animals|Apoptosis|drug effects|Brain Infarction|drug therapy|Brain Ischemia|drug therapy|Carrier Proteins|metabolism|Humans|Mitogen-Activated Protein Kinases|metabolism|Neuroprotective Agents|metabolism|Plasminogen Activator Inhibitor 1|metabolism|Transforming Growth Factor beta|metabolism|Transforming Growth Factor beta1|bcl-Associated Death Protein
Show abstract [+]

[Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?].
Docagne F, Ali C, Lesne S, Nicole O, MacKenzie ET, Buisson A, Vivien D
J Soc Biol 1295-0661
PMID : 12910629
KEYWORDS : Animals|Astrocytes|physiology|Brain Ischemia|genetics|Cell Death|drug effects|Gene Expression Regulation|Humans|Neuroprotective Agents|pharmacology|Plasminogen Activator Inhibitor 1|genetics|Transforming Growth Factor beta|pharmacology
Show abstract [+]

Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.
Valable S, Bellail A, Lesné S, Liot G, Mackenzie ET, Vivien D, Bernaudin M, Petit E
FASEB J 1530-6860
PMID : 12514118
KEYWORDS : Angiogenesis Inducing Agents|pharmacology|Angiopoietin-1|Animals|Apoptosis|Cells, Cultured|Chromones|pharmacology|Culture Media, Serum-Free|Enzyme Activation|Enzyme Inhibitors|pharmacology|Membrane Glycoproteins|pharmacology|Mice|Models, Biological|Morpholines|pharmacology|Neoplasm Proteins|analysis|Neurons|cytology|Neuroprotective Agents|pharmacology|Phosphatidylinositol 3-Kinases|metabolism|Phosphoinositide-3 Kinase Inhibitors|Proto-Oncogene Proteins|Receptor, TIE-2
Show abstract [+]

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.
Gabriel C, Ali C, Lesné S, Fernández-Monreal M, Docagne F, Plawinski L, MacKenzie ET, Buisson A, Vivien D
FASEB J 1530-6860
PMID : 12490542
KEYWORDS : Animals|Apoptosis|drug effects|Astrocytes|cytology|Dose-Response Relationship, Drug|Gene Expression Regulation|drug effects|Mitogen-Activated Protein Kinases|drug effects|N-Methylaspartate|pharmacology|Neurons|cytology|Phosphorylation|drug effects|Plasminogen Activator Inhibitor 1|genetics|RNA, Messenger|drug effects|Tissue Plasminogen Activator|drug effects|Transforming Growth Factor alpha|pharmacology
Show abstract [+]

2002


Matching gene expression with hypometabolism after cerebral ischemia in the nonhuman primate.
Chuquet J, Benchenane K, Liot G, Fernández-Monreal M, Toutain J, Blanchet S, Eveno E, Auffray C, Piétu G, Buisson A, Touzani O, MacKenzie ET, Vivien D
J Cereb Blood Flow Metab 0271-678X
PMID : 12368653
KEYWORDS : Animals|Brain|blood supply|Brain Ischemia|genetics|Cerebral Arteries|metabolism|Cloning, Molecular|Cluster Analysis|DNA, Complementary|Disease Models, Animal|Gene Expression Regulation|Male|Oligonucleotide Array Sequence Analysis|Oxygen Consumption|Papio
Show abstract [+]

Transforming growth factor-beta1-modulated cerebral gene expression.
Lesné S, Blanchet S, Docagne F, Liot G, Plawinski L, MacKenzie ET, Auffray C, Buisson A, Piétu G, Vivien D
J Cereb Blood Flow Metab 0271-678X
PMID : 12218417
KEYWORDS : Animals|Animals, Newborn|Astrocytes|metabolism|Base Sequence|Cells, Cultured|Cerebral Cortex|metabolism|DNA Primers|Gene Expression Regulation|physiology|Glial Fibrillary Acidic Protein|genetics|Humans|Mice|Mice, Transgenic|Nerve Tissue Proteins|genetics|Neurons|metabolism|Oligonucleotide Array Sequence Analysis|Promoter Regions, Genetic|RNA, Messenger|genetics|Transcription, Genetic|Transforming Growth Factor beta|physiology|Transforming Growth Factor beta1
Show abstract [+]

2001


A soluble transforming growth factor-beta (TGF-beta ) type I receptor mimics TGF-beta responses.
Docagne F, Colloc'h N, Bougueret V, Page M, Paput J, Tripier M, Dutartre P, MacKenzie ET, Buisson A, Komesli S, Vivien D
J Biol Chem 0021-9258
PMID : 11544249
KEYWORDS : Amino Acid Sequence|Animals|Base Sequence|Cell Division|physiology|Cell Line|Cricetinae|DNA Primers|Immunoglobulin G|metabolism|Mink|Molecular Sequence Data|Protein Conformation|Receptors, Transforming Growth Factor beta|chemistry|Sequence Homology, Amino Acid|Signal Transduction|Solubility|Transforming Growth Factor beta|metabolism
Show abstract [+]

Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress?
Ali C, Docagne F, Nicole O, Lesné S, Toutain J, Young A, Chazalviel L, Divoux D, Caly M, Cabal P, Derlon JM, MacKenzie ET, Buisson A, Vivien D
J Cereb Blood Flow Metab 0271-678X
PMID : 11435794
KEYWORDS : Animals|Biomarkers|Brain|metabolism|Brain Ischemia|etiology|Gene Expression|Magnetic Resonance Imaging|Male|Middle Cerebral Artery|surgery|Neurons|physiology|Oxygen Consumption|Papio|RNA, Messenger|analysis|Reverse Transcriptase Polymerase Chain Reaction|Tomography, Emission-Computed|Transforming Growth Factor beta|genetics
Show abstract [+]

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.
Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D, Buisson A
Nat Med 1078-8956
PMID : 11135617
KEYWORDS : Animals|Calcium|metabolism|Cell Death|Hydrolysis|Ion Transport|Membrane Potentials|Neurons|metabolism|Receptors, N-Methyl-D-Aspartate|metabolism|Signal Transduction|Tissue Plasminogen Activator|metabolism
Show abstract [+]

2000


Serine protease inhibitors: novel therapeutic targets for stroke?
Vivien D, Buisson A
J Cereb Blood Flow Metab 0271-678X
PMID : 10826525
KEYWORDS : Animals|Cytokines|physiology|Humans|Neurodegenerative Diseases|physiopathology|Serine Endopeptidases|physiology|Serine Proteinase Inhibitors|physiology|Stroke|drug therapy
Show abstract [+]

Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain.
Bernaudin M, Bellail A, Marti HH, Yvon A, Vivien D, Duchatelle I, Mackenzie ET, Petit E
Glia 0894-1491
PMID : 10756076
KEYWORDS : Animals|Astrocytes|metabolism|Brain|metabolism|Cells, Cultured|Erythropoietin|genetics|Hypoxia|genetics|Male|Mice|Mice, Inbred Strains|Neurons|metabolism|Oxidation-Reduction|Oxygen|metabolism|Polymerase Chain Reaction|RNA, Messenger|metabolism|Time Factors
Show abstract [+]

1999


Transforming growth factor-beta1 as a regulator of the serpins/t-PA axis in cerebral ischemia.
Docagne F, Nicole O, Marti HH, MacKenzie ET, Buisson A, Vivien D
FASEB J 0892-6638
PMID : 10428756
KEYWORDS : Amyloid beta-Protein Precursor|Animals|Astrocytes|metabolism|Brain Ischemia|genetics|Carrier Proteins|genetics|Cell Death|genetics|Cells, Cultured|Gene Expression Regulation|Mice|Neurons|pathology|Neuropeptides|genetics|Plasminogen Activator Inhibitor 1|genetics|Protease Nexins|Receptors, Cell Surface|Serpins|genetics|Tissue Plasminogen Activator|genetics|Transforming Growth Factor beta|genetics
Show abstract [+]

1998


Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1.
Buisson A, Nicole O, Docagne F, Sartelet H, Mackenzie ET, Vivien D
FASEB J 0892-6638
PMID : 9837858
KEYWORDS : Animals|Astrocytes|drug effects|Cell Death|drug effects|Mice|N-Methylaspartate|pharmacology|Neuroglia|cytology|Neurons|cytology|Neuroprotective Agents|pharmacology|Plasminogen Activator Inhibitor 1|metabolism|Receptors, Transforming Growth Factor beta|genetics|Serine Proteinase Inhibitors|biosynthesis|Tissue Plasminogen Activator|metabolism|Transforming Growth Factor beta|pharmacology|Up-Regulation
Show abstract [+]

1996


An inositolphosphate glycan released by TGF-beta mimics the proliferative but not the transcriptional effects of the factor and requires functional receptors.
Bogdanowicz P, Vivien D, Felisaz N, Léon V, Pujol JP
Cell Signal 0898-6568
PMID : 9023015
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Division|Cell Line|Cells, Cultured|DNA|biosynthesis|Gene Expression Regulation|Genes, Reporter|Inositol Phosphates|metabolism|Mink|Molecular Mimicry|Polysaccharides|metabolism|Rabbits|Receptors, Transforming Growth Factor beta|metabolism|Signal Transduction|Transcription, Genetic|Transforming Growth Factor beta|pharmacology
Show abstract [+]

[Physiopathology of arthrotic cartilage].
Pujol JP, Galéra P, Vivien D, Redini F, Boumediene K
Rev Prat 0035-2640
PMID : 8978150
KEYWORDS : Animals|Cartilage, Articular|metabolism|Humans|Osteoarthritis|metabolism|Rabbits|Receptors, Transforming Growth Factor beta|genetics|Transforming Growth Factor beta|genetics

1995


Modulation of rabbit articular chondrocyte (RAC) proliferation by TGF-beta isoforms.
Boumediene K, Vivien D, Macro M, Bogdanowicz P, Lebrun E, Pujol JP
Cell Prolif 0960-7722
PMID : 7772639
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Count|Cell Cycle|drug effects|Cell Division|drug effects|Cells, Cultured|Flow Cytometry|Rabbits|Thymidine|Transforming Growth Factor beta|biosynthesis|Tritium
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Ligand-induced recruitment and phosphorylation of reduced TGF-beta type I receptor.
Vivien D, Wrana JL
Exp Cell Res 0014-4827
PMID : 7589256
KEYWORDS : Animals|Cell Line|metabolism|Dithiothreitol|pharmacology|Epithelial Cells|Epithelium|ultrastructure|Ligands|Mink|Phosphorylation|Receptors, Transforming Growth Factor beta|metabolism|Signal Transduction|physiology
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1994


Different phosphorylated forms of inositolphosphate glycan could be involved in the transforming growth factor-beta 1 (TGF-beta 1) signalling pathway.
Vivien D, Bogdanowicz P, Boumediene K, Martiny L, Haye B, Pujol JP
Cell Signal 0898-6568
PMID : 8086280
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|Cell Division|Cells, Cultured|Chromatography, Ion Exchange|DNA Replication|drug effects|Glucosamine|metabolism|Glycosylphosphatidylinositols|metabolism|Humans|Inositol Phosphates|metabolism|Phosphorylation|Polysaccharides|metabolism|Protein Kinases|metabolism|Rabbits|Signal Transduction|Transforming Growth Factor beta|metabolism
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Transforming growth factor-beta (TGF-beta) and articular chondrocytes.
Pujol JP, Galera P, Pronost S, Boumediene K, Vivien D, Macro M, Min W, Redini F, Penfornis H, Daireaux M
Ann Endocrinol (Paris) 0003-4266
PMID : 7802428
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Division|drug effects|Extracellular Matrix|metabolism|G2 Phase|Interleukin-1|antagonists & inhibitors|Rabbits|Receptors, Transforming Growth Factor beta|metabolism|Transforming Growth Factor beta|pharmacology
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1993


Interleukin-1 and naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC).
Pronost S, Delecoeuillerie G, Rédini F, Paolozzi L, Vivien D, Galéra P, Loyau G, Pujol JP
Agents Actions Suppl 0379-0363
PMID : 8456631
KEYWORDS : Arthritis, Rheumatoid|pathology|Down-Regulation|drug effects|Humans|Interleukin-1|metabolism|Iodine Radioisotopes|Kinetics|Naproxen|pharmacology|Receptors, Interleukin-1|drug effects|Recombinant Proteins|pharmacology|Synovial Membrane|pathology
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IPG (inositolphosphate glycan) as a cellular signal for TGF-beta 1 modulation of chondrocyte cell cycle.
Vivien D, Petitfrère E, Martiny L, Sartelet H, Galéra P, Haye B, Pujol JP
J Cell Physiol 0021-9541
PMID : 8388000
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cell Division|Cells, Cultured|DNA Replication|drug effects|Glycosylphosphatidylinositols|physiology|Humans|Hydrolysis|Inositol Phosphates|metabolism|Phosphatidylinositol Diacylglycerol-Lyase|Phosphoinositide Phospholipase C|Phosphoric Diester Hydrolases|metabolism|Polysaccharides|metabolism|Rabbits|Receptors, Cell Surface|physiology|Receptors, Transforming Growth Factor beta|Signal Transduction|Transforming Growth Factor beta|pharmacology
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Human rheumatoid synovial cells (HRSC) in culture express TGF-beta receptors and are growth stimulated by the factor.
Pronost S, Rédini F, Vivien D, Galéra P, Pujol JP
Agents Actions Suppl 0379-0363
PMID : 8384400
KEYWORDS : Arthritis, Rheumatoid|metabolism|Autoradiography|Cell Division|drug effects|Cells, Cultured|Cross-Linking Reagents|pharmacology|Electrophoresis, Polyacrylamide Gel|Humans|Iodine Radioisotopes|Kinetics|Receptors, Cell Surface|biosynthesis|Receptors, Transforming Growth Factor beta|Stimulation, Chemical|Synovial Membrane|cytology|Transforming Growth Factor beta|pharmacology
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Rabbit articular chondrocytes (RAC) express distinct transforming growth factor-beta receptor phenotypes as a function of cell cycle phases.
Vivien D, Redini F, Galéra P, Lebrun E, Loyau G, Pujol JP
Exp Cell Res 0014-4827
PMID : 8384118
KEYWORDS : Animals|Binding Sites|Cartilage, Articular|metabolism|Cell Cycle|physiology|Cell Division|drug effects|Cells, Cultured|drug effects|Phenotype|Rabbits|Receptors, Cell Surface|physiology|Receptors, Transforming Growth Factor beta|Transforming Growth Factor beta|metabolism
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1992


Effect of transforming growth factor-beta 1 (TGF-beta 1) on matrix synthesis by monolayer cultures of rabbit articular chondrocytes during the dedifferentiation process.
Galéra P, Rédini F, Vivien D, Bonaventure J, Penfornis H, Loyau G, Pujol JP
Exp Cell Res 0014-4827
PMID : 1572404
KEYWORDS : Animals|Cartilage, Articular|metabolism|Cell Differentiation|drug effects|Cell Division|drug effects|Cells, Cultured|Collagen|biosynthesis|Extracellular Matrix|metabolism|Gene Expression|drug effects|Glycosaminoglycans|biosynthesis|In Vitro Techniques|Proteoglycans|metabolism|RNA, Messenger|genetics|Rabbits|Transforming Growth Factor beta|pharmacology
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Transforming growth factor-beta 1 (TGF-beta 1) up-regulation of collagen type II in primary cultures of rabbit articular chondrocytes (RAC) involves increased mRNA levels without affecting mRNA stability and procollagen processing.
Galéra P, Vivien D, Pronost S, Bonaventure J, Rédini F, Loyau G, Pujol JP
J Cell Physiol 0021-9541
PMID : 1447320
KEYWORDS : Animals|Ascorbic Acid|pharmacology|Cartilage, Articular|cytology|Cells, Cultured|Collagen|metabolism|Dinoprostone|biosynthesis|Drug Stability|Electrophoresis, Polyacrylamide Gel|Homeostasis|Indomethacin|pharmacology|Isomerism|Procollagen|classification|Protein Processing, Post-Translational|drug effects|RNA, Messenger|metabolism|Rabbits|Transforming Growth Factor beta|pharmacology
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Flow cytometric detection of transforming growth factor-beta expression in rabbit articular chondrocytes (RAC) in culture--association with S-phase traverse.
Vivien D, Boumedienne K, Galera P, Lebrun E, Pujol JP
Exp Cell Res 0014-4827
PMID : 1426052
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|Cell Division|Cells, Cultured|DNA|analysis|Flow Cytometry|methods|Rabbits|S Phase|physiology|Transforming Growth Factor beta|biosynthesis
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TGF-beta-induced G2/M delay in proliferating rabbit articular chondrocytes is associated with an enhancement of replication rate and a cAMP decrease: possible involvement of pertussis toxin-sensitive pathway.
Vivien D, Galéra P, Lebrun E, Daireaux M, Loyau G, Pujol JP
J Cell Physiol 0021-9541
PMID : 1346400
KEYWORDS : Adenylate Cyclase Toxin|Animals|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cholera Toxin|pharmacology|Cyclic AMP|metabolism|DNA Replication|drug effects|Flow Cytometry|In Vitro Techniques|Nuclear Proteins|metabolism|Pertussis Toxin|Proliferating Cell Nuclear Antigen|Rabbits|Transforming Growth Factor beta|pharmacology|Virulence Factors, Bordetella|pharmacology
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1991


Differential response of cultured rabbit articular chondrocytes (RAC) to transforming growth factor beta (TGF-beta)-evidence for a role of serum factors.
Vivien D, Galera P, Loyau G, Pujol JP
Eur J Cell Biol 0171-9335
PMID : 1879436
KEYWORDS : Animals|Blood|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cell Division|drug effects|Cells, Cultured|Culture Media|DNA|biosynthesis|Epidermal Growth Factor|pharmacology|Kinetics|Platelet-Derived Growth Factor|pharmacology|Rabbits|Transforming Growth Factor beta|pharmacology
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1990


Differential effects of transforming growth factor-beta and epidermal growth factor on the cell cycle of cultured rabbit articular chondrocytes.
Vivien D, Galéra P, Lebrun E, Loyau G, Pujol JP
J Cell Physiol 0021-9541
PMID : 2358472
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cell Division|drug effects|Cells, Cultured|DNA|biosynthesis|Epidermal Growth Factor|pharmacology|Plateletpheresis|Rabbits|Transforming Growth Factors|pharmacology
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Environmental enrichment alleviates the deleterious effects of stress in experimental autoimmune encephalomyelitis.
Fournier AP, Baudron E, Wagnon I, Aubert P, Vivien D, Neunlist M, Bardou I, Docagne F
Mult Scler J Exp Transl Clin 2055-2173
PMID : 33101703
Show abstract [+]

Transforming growth factor-beta signalling in brain disorders.
Vivien D, Ali C
Cytokine Growth Factor Rev 1359-6101
PMID : 16271500
KEYWORDS : Animals|Brain Diseases|drug therapy|Disease Progression|Humans|Receptors, Transforming Growth Factor beta|physiology|Signal Transduction|physiology|Transforming Growth Factor beta|physiology
Show abstract [+]