Conference: Dr. Pablo DECUZZI

170 publications found


HLA-Class II Artificial Antigen Presenting Cells in CD4 T Cell-Based Immunotherapy.
Couture A, Garnier A, Docagne F, Boyer O, Vivien D, Le-Mauff B, Latouche JB, Toutirais O
Front Immunol 1664-3224
PMID : 31156634
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Post-synaptic Release of the Neuronal Tissue-Type Plasminogen Activator (tPA).
Lenoir S, Varangot A, Lebouvier L, Galli T, Hommet Y, Vivien D
Front Cell Neurosci 1662-5102
PMID : 31105531
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Recent Advances in Nanomedicine for Ischemic and Hemorrhagic Stroke.
Bonnard T, Gauberti M, Martinez de Lizarrondo S, Campos F, Vivien D
Stroke 1524-4628
PMID : 30932782

Tissue-Type Plasminogen Activator Controlled Corticogenesis Through a Mechanism Dependent of NMDA Receptors Expressed on Radial Glial Cells.
Pasquet N, Douceau S, Naveau M, Lesept F, Louessard M, Lebouvier L, Hommet Y, Vivien D, Bardou I
Cereb. Cortex 1460-2199
PMID : 29878094
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The Age-Well observational study on expert meditators in the Medit-Ageing European project.
Lutz A, Klimecki OM, Collette F, Poisnel G, Arenaza-Urquijo E, Marchant NL, De La Sayette V, Rauchs G, Salmon E, Vuilleumier P, Frison E, Vivien D, Chételat G,
Alzheimers Dement (N Y) 2352-8737
PMID : 30662933
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The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD).
Marchant NL, Barnhofer T, Klimecki OM, Poisnel G, Lutz A, Arenaza-Urquijo E, Collette F, Wirth M, Schild AK, Coll-Padrós N, Reyrolle L, Horney D, Krolak-Salmon P, Molinuevo JL, Walker Z, Maillard A, Frison E, Jessen F, Chételat G,
Alzheimers Dement (N Y) 2352-8737
PMID : 30581979
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The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults.
Poisnel G, Arenaza-Urquijo E, Collette F, Klimecki OM, Marchant NL, Wirth M, de La Sayette V, Rauchs G, Salmon E, Vuilleumier P, Frison E, Maillard A, Vivien D, Lutz A, Chételat G,
Alzheimers Dement (N Y) 2352-8737
PMID : 30581977
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Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke.
Gauberti M, Lapergue B, Martinez de Lizarrondo S, Vivien D, Richard S, Bracard S, Piotin M, Gory B
Stroke 1524-4628
PMID : 30571423
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The role of plasminogen activators in stroke treatment: fibrinolysis and beyond.
Thiebaut AM, Gauberti M, Ali C, Martinez De Lizarrondo S, Vivien D, Yepes M, Roussel BD
Lancet Neurol 1474-4465
PMID : 30507392
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Cerebrospinal fluid leakage after posterior fossa surgery may impair brain metabolite clearance.
Goulay R, Aron Badin R, Flament J, Emery E, Hantraye P, Vivien D, Gaberel T
Neurochirurgie 1773-0619
PMID : 30477647
KEYWORDS : Animals|Brain|metabolism|Cerebrospinal Fluid|drug effects|Cerebrospinal Fluid Rhinorrhea|etiology|Gadolinium|therapeutic use|Glymphatic System|surgery|Humans|Primates
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A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis.
Vezain M, Lecuyer M, Rubio M, Dupé V, Ratié L, David V, Pasquier L, Odent S, Coutant S, Tournier I, Trestard L, Adle-Biassette H, Vivien D, Frébourg T, Gonzalez BJ, Laquerrière A, Saugier-Veber P
Acta Neuropathol Commun 2051-5960
PMID : 30340542
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Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-Bclx strategies through Mcl-1 down-regulation.
Bonnefond ML, Florent R, Lenoir S, Lambert B, Abeilard E, Giffard F, Louis MH, Elie N, Briand M, Vivien D, Poulain L, Gauduchon P, N'Diaye M
Oncotarget 1949-2553
PMID : 30338034
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Anti-inflammatory treatments for stroke: from bench to bedside.
Drieu A, Levard D, Vivien D, Rubio M
Ther Adv Neurol Disord 1756-2856
PMID : 30083232
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Cerebrospinal fluid flow increases from newborn to adult stages.
Di Palma C, Goulay R, Chagnot S, Martinez De Lizarrondo S, Anfray A, Salaun JP, Maubert E, Lechapt-Zalcman E, Andreiuolo F, Gakuba C, Emery E, Vivien D, Gauberti M, Gaberel T
Dev Neurobiol 1932-846X
PMID : 30027587
KEYWORDS : Adult|Animals|Animals, Newborn|cerebrospinal fluid|Biological Transport|physiology|Brain|metabolism|Cerebral Ventricles|physiology|Cerebrospinal Fluid|physiology|Humans|Magnetic Resonance Imaging|methods|Mice|Rats, Wistar
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Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke.
Gauberti M, Potzeha F, Vivien D, Martinez de Lizarrondo S
Front Med (Lausanne) 2296-858X
PMID : 30018956
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Erratum to: Molecular Magnetic Resonance Imaging (mMRI).
Gauberti M, Fournier AP, Vivien D, Martinez de Lizarrondo S
Methods Mol. Biol. 1940-6029
PMID : 29605882

Modification of apparent intracerebral hematoma volume on T2-weighted images during normobaric oxygen therapy may contribute to false diagnosis.
Goulay R, Drieu A, Di Palma C, Pro-Sistiaga P, Delcroix N, Chazalviel L, Saulnier R, Gakuba C, Goursaud S, Young AR, Gauberti M, Orset C, Emery E, Vivien D, Gaberel T
J Clin Neurosci 1532-2653
PMID : 29571939
KEYWORDS : Animals|Cerebral Hemorrhage|diagnostic imaging|Diagnostic Errors|Hematoma|diagnostic imaging|Magnetic Resonance Imaging|standards|Oxygen Inhalation Therapy|adverse effects|Swine
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Influence of on-going treatment with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker on the outcome of patients treated with intravenous rt-PA for ischemic stroke.
Gilliot S, Sibon I, Mas JL, Moulin T, Béjot Y, Cordonnier C, Giroud M, Odou P, Bordet R, Vivien D, Leys D,
J. Neurol. 1432-1459
PMID : 29549467
KEYWORDS : Administration, Intravenous|Aged|Aged, 80 and over|Angiotensin Receptor Antagonists|therapeutic use|Angiotensin-Converting Enzyme Inhibitors|therapeutic use|Brain Ischemia|complications|Female|Fibrinolytic Agents|therapeutic use|Follow-Up Studies|Humans|Intracranial Hemorrhages|complications|Male|Middle Aged|Prospective Studies|Recombinant Proteins|therapeutic use|Stroke|complications|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
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Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.
Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A
Sci Transl Med 1946-6242
PMID : 29540615
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Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System.
Gauberti M, Fournier AP, Docagne F, Vivien D, Martinez de Lizarrondo S
Theranostics 1838-7640
PMID : 29507614
KEYWORDS : Animals|Central Nervous System|blood supply|Dextrans|chemistry|Endothelial Cells|metabolism|Humans|Magnetic Resonance Imaging|Magnetite Nanoparticles|chemistry|Molecular Imaging|Neurodegenerative Diseases|diagnostic imaging
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Reduced spinal cord parenchymal cerebrospinal fluid circulation in experimental autoimmune encephalomyelitis.
Fournier AP, Gauberti M, Quenault A, Vivien D, Macrez R, Docagne F
J. Cereb. Blood Flow Metab. 1559-7016
PMID : 29376456
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General Anesthesia Inhibits the Activity of the "Glymphatic System".
Gakuba C, Gaberel T, Goursaud S, Bourges J, Di Palma C, Quenault A, Martinez de Lizarrondo S, Vivien D, Gauberti M
Theranostics 1838-7640
PMID : 29344300
KEYWORDS : Anesthesia, General|adverse effects|Anesthetics, Inhalation|adverse effects|Animals|Contrast Media|pharmacokinetics|Fluorescent Dyes|pharmacokinetics|Glymphatic System|diagnostic imaging|Magnetic Resonance Imaging|methods|Male|Mice|Spectroscopy, Near-Infrared|methods
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Molecular Magnetic Resonance Imaging (mMRI).
Gauberti M, Fournier AP, Vivien D, Martinez de Lizarrondo S
Methods Mol. Biol. 1940-6029
PMID : 29341017
KEYWORDS : Animals|Brain|metabolism|Contrast Media|Ferric Compounds|chemistry|Magnetic Resonance Imaging|methods|Mice|Molecular Imaging|methods|Vascular Cell Adhesion Molecule-1|metabolism
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Worse Outcome in Stroke Patients Treated with rt-PA Without Early Reperfusion: Associated Factors.
Iglesias-Rey R, Rodríguez-Yáñez M, Rodríguez-Castro E, Pumar JM, Arias S, Santamaría M, López-Dequidt I, Hervella P, Correa-Paz C, Sobrino T, Vivien D, Campos F, Castellanos M, Castillo J
Transl Stroke Res 1868-601X
PMID : 29116527
KEYWORDS : Aged|Aged, 80 and over|Cohort Studies|Female|Fibrinolytic Agents|adverse effects|Hemorrhage|chemically induced|Humans|Male|Middle Aged|ROC Curve|Reperfusion|Stroke|drug therapy|Tissue Plasminogen Activator|adverse effects|Treatment Outcome
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Optimized tPA: A non-neurotoxic fibrinolytic agent for the drainage of intracerebral hemorrhages.
Goulay R, Naveau M, Gaberel T, Vivien D, Parcq J
J. Cereb. Blood Flow Metab. 1559-7016
PMID : 28741405
KEYWORDS : Animals|Brain Edema|drug therapy|Cerebral Hemorrhage|drug therapy|Clinical Trials, Phase III as Topic|Disease Models, Animal|Drug Evaluation, Preclinical|Fibrinolytic Agents|pharmacology|Humans|Male|Mice|Protein Engineering|Recombinant Proteins|genetics|Swine|Tissue Plasminogen Activator|genetics
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Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery.
Quattromani MJ, Pruvost M, Guerreiro C, Backlund F, Englund E, Aspberg A, Jaworski T, Hakon J, Ruscher K, Kaczmarek L, Vivien D, Wieloch T
Mol. Neurobiol. 1559-1182
PMID : 28290150
KEYWORDS : Aged|Aged, 80 and over|Animals|Environment|Extracellular Matrix|metabolism|Female|Humans|Inflammation Mediators|metabolism|Male|Middle Aged|Neuronal Plasticity|physiology|Rats|Recovery of Function|physiology|Stroke|metabolism|Stroke Rehabilitation|methods
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ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function.
Pruvost M, Lépine M, Leonetti C, Etard O, Naveau M, Agin V, Docagne F, Maubert E, Ali C, Emery E, Vivien D
Glia 1098-1136
PMID : 28850711
KEYWORDS : ADAMTS4 Protein|genetics|Animals|Animals, Newborn|Calcium-Binding Proteins|metabolism|Corpus Callosum|metabolism|Disease Models, Animal|Evoked Potentials, Somatosensory|genetics|Gait Disorders, Neurologic|etiology|Locomotion|genetics|Male|Mice|Mice, Transgenic|Microfilament Proteins|metabolism|Microscopy, Electron|Movement Disorders|genetics|Myelin Basic Protein|metabolism|Nerve Tissue Proteins|metabolism|Oligodendroglia|metabolism|Receptor, Platelet-Derived Growth Factor alpha|metabolism|Statistics, Nonpar
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Nicotinamide riboside, a form of vitamin B, protects against excitotoxicity-induced axonal degeneration.
Vaur P, Brugg B, Mericskay M, Li Z, Schmidt MS, Vivien D, Orset C, Jacotot E, Brenner C, Duplus E
FASEB J. 1530-6860
PMID : 28842432
KEYWORDS : Animals|Axons|drug effects|Cell Death|drug effects|Cells, Cultured|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|N-Methylaspartate|pharmacology|Neurons|drug effects|Neuroprotective Agents|pharmacology|Niacinamide|analogs & derivatives|Real-Time Polymerase Chain Reaction
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Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain.
Lecuyer M, Rubio M, Chollat C, Lecointre M, Jégou S, Leroux P, Cleren C, Leroux-Nicollet I, Marpeau L, Vivien D, Marret S, Gonzalez BJ
Pharmacol Res Perspect 2052-1707
PMID : 28805973
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Can the benefits of rtPA treatment for stroke be improved?
Vivien D
Rev. Neurol. (Paris) 0035-3787
PMID : 28797689
KEYWORDS : Humans|Plasminogen Activators|therapeutic use|Stroke|drug therapy|Thrombectomy|Tissue Plasminogen Activator|therapeutic use
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The choroid plexus is a key cerebral invasion route for T cells after stroke.
Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A
Acta Neuropathol. 1432-0533
PMID : 28762187
KEYWORDS : Aged|Aged, 80 and over|Animals|Brain Injuries, Traumatic|pathology|Brain Ischemia|pathology|Cell Movement|physiology|Cerebral Cortex|pathology|Chemokine CCL2|metabolism|Choroid Plexus|pathology|Disease Models, Animal|Female|Humans|Male|Mice, Inbred C57BL|Mice, Transgenic|Myeloid Cells|pathology|Stroke|pathology|T-Lymphocytes|pathology
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Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation.
Labeyrie PE, Goulay R, Martinez de Lizarrondo S, Hébert M, Gauberti M, Maubert E, Delaunay B, Gory B, Signorelli F, Turjman F, Touzé E, Courthéoux P, Vivien D, Orset C
Stroke 1524-4628
PMID : 28754830
KEYWORDS : Adult|Aneurysm, Ruptured|diagnostic imaging|Animals|Female|Fluorescent Antibody Technique|Humans|Immunohistochemistry|Intracranial Aneurysm|diagnostic imaging|Magnetic Resonance Imaging|Mice|Mice, Knockout|Plasminogen Activator Inhibitor 1|genetics|Rupture, Spontaneous|Tissue Plasminogen Activator|genetics
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Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death.
Louessard M, Bardou I, Lemarchand E, Thiebaut AM, Parcq J, Leprince J, Terrisse A, Carraro V, Fafournoux P, Bruhat A, Orset C, Vivien D, Ali C, Roussel BD
Cell Death Differ. 1476-5403
PMID : 28644439
KEYWORDS : Activating Transcription Factor 4|metabolism|Animals|Apoptosis|drug effects|Cell Death|drug effects|Endoplasmic Reticulum Stress|drug effects|Fibrinolytic Agents|pharmacology|Heat-Shock Proteins|metabolism|Mice|Neurons|cytology|Protein-Serine-Threonine Kinases|metabolism|Signal Transduction|drug effects|Thromboembolism|therapy|Tissue Plasminogen Activator|pharmacology|Unfolded Protein Response|drug effects
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Are Distal and Proximal Visual Cues Equally Important during Spatial Learning in Mice? A Pilot Study of Overshadowing in the Spatial Domain.
Hébert M, Bulla J, Vivien D, Agin V
Front Behav Neurosci 1662-5153
PMID : 28634446
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Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin.
Fournier AP, Quenault A, Martinez de Lizarrondo S, Gauberti M, Defer G, Vivien D, Docagne F, Macrez R
Proc. Natl. Acad. Sci. U.S.A. 1091-6490
PMID : 28533365
KEYWORDS : Animals|Blood-Brain Barrier|diagnostic imaging|Brain|pathology|Contrast Media|Disease Models, Animal|Disease Progression|Encephalomyelitis, Autoimmune, Experimental|pathology|Magnetic Resonance Imaging|methods|Male|Mice|Mice, Inbred C57BL|Multiple Sclerosis|diagnostic imaging|P-Selectin|metabolism|Recurrence|Spinal Cord|pathology
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Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate.
Goulay R, Flament J, Gauberti M, Naveau M, Pasquet N, Gakuba C, Emery E, Hantraye P, Vivien D, Aron-Badin R, Gaberel T
Stroke 1524-4628
PMID : 28526764
KEYWORDS : Animals|Brain|diagnostic imaging|Cerebrovascular Circulation|physiology|Macaca fascicularis|Male|Parenchymal Tissue|diagnostic imaging|Primates|Severity of Illness Index|Subarachnoid Hemorrhage|cerebrospinal fluid
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Potent Thrombolytic Effect of -Acetylcysteine on Arterial Thrombi.
Martinez de Lizarrondo S, Gakuba C, Herbig BA, Repessé Y, Ali C, Denis CV, Lenting PJ, Touzé E, Diamond SL, Vivien D, Gauberti M
Circulation 1524-4539
PMID : 28487393
KEYWORDS : Acetylcysteine|pharmacology|Animals|Blood Platelets|cytology|Chlorides|toxicity|Disease Models, Animal|Ferric Compounds|toxicity|Fibrinolytic Agents|pharmacology|Infarction, Middle Cerebral Artery|drug therapy|Male|Mice|Platelet Aggregation|drug effects|Ristocetin|pharmacology|Thromboembolism|chemically induced|Thrombosis|prevention & control|Tissue Plasminogen Activator|therapeutic use|von Willebrand Factor|chemistry
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Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin.
Briens A, Bardou I, Lebas H, Miles LA, Parmer RJ, Vivien D, Docagne F
Cell Discov 2056-5968
PMID : 28417010
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New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator.
Roncal C, Martinez de Lizarrondo S, Salicio A, Chevilley A, Rodriguez JA, Rosell A, Couraud PO, Weksler B, Montaner J, Vivien D, Páramo JA, Orbe J
Cardiovasc. Res. 1755-3245
PMID : 28379489
KEYWORDS : Animals|Behavior, Animal|drug effects|Brain|drug effects|Calcium Signaling|drug effects|Capillary Permeability|drug effects|Cell Survival|drug effects|Cells, Cultured|Claudin-5|metabolism|Disease Models, Animal|Drug Therapy, Combination|Electric Impedance|Endothelial Cells|drug effects|Fibrinolytic Agents|administration & dosage|Humans|Infarction, Middle Cerebral Artery|metabolism|Male|Matrix Metalloproteinase 10|administration & dosage|Mice, Inbred C57BL|Mitogen-Activated Protein Kinase 1|metabolism|Mitoge
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Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination.
Leonetti C, Macrez R, Pruvost M, Hommet Y, Bronsard J, Fournier A, Perrigault M, Machin I, Vivien D, Clemente D, De Castro F, Maubert E, Docagne F
Mol Neurodegener 1750-1326
PMID : 28231842
KEYWORDS : Animals|Brain Injuries|pathology|Cell Differentiation|drug effects|Cell Movement|drug effects|Central Nervous System|drug effects|Corpus Callosum|drug effects|Embryo, Mammalian|Epidermal Growth Factor|Imaging, Three-Dimensional|Immunoblotting|Immunohistochemistry|Magnetic Resonance Imaging|Mice|Mice, Inbred C57BL|Mice, Knockout|Myelin Sheath|drug effects|Neural Stem Cells|cytology|Oligodendroglia|cytology|Tissue Plasminogen Activator|pharmacology|White Matter|drug effects
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ADAMTS-4 in central nervous system pathologies.
Lemarchant S, Wojciechowski S, Vivien D, Koistinaho J
J. Neurosci. Res. 1097-4547
PMID : 28084617
KEYWORDS : ADAMTS4 Protein|Animals|Central Nervous System Diseases|metabolism|Humans
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Lack of collagen XV is protective after ischemic stroke in mice.
Dhungana H, Huuskonen MT, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen KM, Malm T, Koistinaho J, Lemarchant S
Cell Death Dis 2041-4889
PMID : 28079884
KEYWORDS : Animals|Brain Ischemia|genetics|Cerebral Cortex|metabolism|Collagen|genetics|Disease Models, Animal|Humans|Mice|Mice, Knockout|Neuroprotection|genetics|Stroke|genetics|Tissue Engineering|Tissue Plasminogen Activator|administration & dosage|Tissue Scaffolds|Vascular Endothelial Growth Factor A|genetics
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Recent progress in translational research on neurovascular and neurodegenerative disorders.
Demuth HU, Dijkhuizen RM, Farr TD, Gelderblom M, Horsburgh K, Iadecola C, Mcleod DD, Michalski D, Murphy TH, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Saur D, Savitz SI, Schilling S, Spratt NJ, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M, Boltze J,
Restor. Neurol. Neurosci. 1878-3627
PMID : 28059802
KEYWORDS : Animals|Cerebrovascular Disorders|diagnosis|Humans|Neurodegenerative Diseases|diagnosis|Translational Medical Research
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Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack.
Quenault A, Martinez de Lizarrondo S, Etard O, Gauberti M, Orset C, Haelewyn B, Segal HC, Rothwell PM, Vivien D, Touzé E, Ali C
Brain 1460-2156
PMID : 28031221
KEYWORDS : Animals|Biomarkers|metabolism|Disease Models, Animal|Endothelial Cells|Ischemic Attack, Transient|diagnostic imaging|Magnetic Resonance Imaging|methods|Male|Mice|Molecular Imaging|methods|P-Selectin|metabolism|Stroke|diagnostic imaging
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F376A/M388A-solulin, a new promising antifibrinolytic for severe haemophilia A.
Parcq J, Petersen KU, Borel-Derlon A, Gautier P, Ebel M, Vivien D, Repessé Y
Haemophilia 1365-2516
PMID : 27928886
KEYWORDS : Factor VIII|therapeutic use|Fibrinolysis|physiology|Hemophilia A|drug therapy|Humans
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Distant Space Processing is Controlled by tPA-dependent NMDA Receptor Signaling in the Entorhinal Cortex.
Hébert M, Anfray A, Chevilley A, Martinez de Lizarrondo S, Quenault A, Louessard M, Roussel BD, Obiang P, Save E, Orset C, Maubert E, Vivien D, Agin V
Cereb. Cortex 1460-2199
PMID : 27613436
KEYWORDS : Aging|Animals|Calcium|metabolism|Entorhinal Cortex|metabolism|Female|Hippocampus|metabolism|Male|Mice, Knockout|Neurons|metabolism|Receptors, N-Methyl-D-Aspartate|metabolism|Signal Transduction|physiology|Tissue Plasminogen Activator|deficiency
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The "inflammatory penumbra" in ischemic stroke: From clinical data to experimental evidence.
Gauberti M, De Lizarrondo SM, Vivien D
Eur Stroke J 2396-9881
PMID : 31008264
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[Role of endothelial NMDA receptors in a mouse model of multiple sclerosis].
Macrez R, Vivien D, Docagne F
Med Sci (Paris) 1958-5381
PMID : 28044968
KEYWORDS : Animals|Antibodies, Monoclonal|therapeutic use|Blood-Brain Barrier|metabolism|Disease Models, Animal|Endothelium, Vascular|metabolism|Humans|Mice|Multiple Sclerosis|drug therapy|Receptors, N-Methyl-D-Aspartate|antagonists & inhibitors|Remission Induction

Retinal safety of intravitreal rtPA in healthy rats and under excitotoxic conditions.
Daruich A, Parcq J, Delaunay K, Naud MC, Le Rouzic Q, Picard E, Crisanti P, Vivien D, Berdugo M, Behar-Cohen F
Mol. Vis. 1090-0535
PMID : 27881907
KEYWORDS : Animals|Apoptosis|drug effects|Electroretinography|Intravitreal Injections|Male|Neurotoxins|toxicity|Rats, Long-Evans|Recombinant Proteins|administration & dosage|Retina|Retinal Ganglion Cells|drug effects|Tissue Plasminogen Activator|administration & dosage
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Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors.
Lesept F, Chevilley A, Jezequel J, Ladépêche L, Macrez R, Aimable M, Lenoir S, Bertrand T, Rubrecht L, Galea P, Lebouvier L, Petersen KU, Hommet Y, Maubert E, Ali C, Groc L, Vivien D
Cell Death Dis 2041-4889
PMID : 27831563
KEYWORDS : Animals|Antibodies, Monoclonal|pharmacology|Calcium|metabolism|Cell Death|drug effects|Cell Membrane|drug effects|Diffusion|Fibrinolysin|pharmacology|HEK293 Cells|Humans|Lysine|metabolism|Male|Mice, Inbred BALB C|Neurons|cytology|Neurotoxins|toxicity|Protein Domains|Rats, Sprague-Dawley|Receptors, N-Methyl-D-Aspartate|chemistry|Signal Transduction|drug effects|Synapses|drug effects|Tissue Plasminogen Activator|pharmacology
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Proportion of single-chain recombinant tissue plasminogen activator and outcome after stroke.
Leys D, Hommet Y, Jacquet C, Moulin S, Sibon I, Mas JL, Moulin T, Giroud M, Sagnier S, Cordonnier C, Medeiros de Bustos E, Turc G, Ronzière T, Bejot Y, Detante O, Ouk T, Mendyk AM, Favrole P, Zuber M, Triquenot-Bagan A, Ozkul-Wermester O, Montoro FM, Lamy C, Faivre A, Lebouvier L, Potey C, Poli M, Hénon H, Renou P, Dequatre-Ponchelle N, Bodenant M, Debruxelles S, Rossi C, Bordet R, Vivien D,
Neurology 1526-632X
PMID : 27815401
KEYWORDS : Aged|Aged, 80 and over|Brain Ischemia|complications|Cerebral Hemorrhage|complications|Disability Evaluation|Female|Fibrinolytic Agents|chemistry|Humans|Male|Middle Aged|Recombinant Proteins|chemistry|Seizures|complications|Severity of Illness Index|Stroke|complications|Thrombolytic Therapy|Time-to-Treatment|Tissue Plasminogen Activator|chemistry|Treatment Outcome
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Valproic acid: a relevant thromboprophylactic strategy?
Martinez de Lizarrondo S, Gauberti M, Vivien D
J. Thromb. Haemost. 1538-7836
PMID : 27709777
KEYWORDS : Humans|Valproic Acid

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities.
Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F
Lancet Neurol 1474-4465
PMID : 27571160
KEYWORDS : Biomarkers|metabolism|Excitatory Amino Acid Antagonists|therapeutic use|Glutamic Acid|metabolism|Humans|Multiple Sclerosis|drug therapy
Show abstract [+]

Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism.
Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I, Orset C, Pruvost M, Anfray A, Frigout Y, Hommet Y, Lebouvier L, Montaner J, Vivien D, Gauberti M
Blood 1528-0020
PMID : 27531677
KEYWORDS : Animals|Blood-Brain Barrier|drug effects|Bradykinin|metabolism|Bradykinin B2 Receptor Antagonists|pharmacology|Brain|drug effects|Capillary Permeability|drug effects|Fibrinolysin|metabolism|Fibrinolysis|drug effects|Hydrodynamics|Mice|Mice, Transgenic|Receptor, Bradykinin B2|genetics|Signal Transduction|drug effects|Tissue Plasminogen Activator|genetics
Show abstract [+]

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.
Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F
Brain 1460-2156
PMID : 27435092
KEYWORDS : Animals|Blood-Brain Barrier|metabolism|Encephalomyelitis, Autoimmune, Experimental|drug therapy|Endothelial Cells|Excitatory Amino Acid Antagonists|pharmacology|HEK293 Cells|Humans|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|Nerve Tissue Proteins|drug effects|Receptors, N-Methyl-D-Aspartate|drug effects|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis.
Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, El Amki M, Fatar M, Garcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D
Stroke 1524-4628
PMID : 27032444
KEYWORDS : Animals|Brain Ischemia|drug therapy|Disease Models, Animal|Fibrinolytic Agents|administration & dosage|Infarction, Middle Cerebral Artery|drug therapy|Male|Mice|Mice, Inbred C57BL|Stroke|drug therapy|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Nano-zymography Using Laser-Scanning Confocal Microscopy Unmasks Proteolytic Activity of Cell-Derived Microparticles.
Briens A, Gauberti M, Parcq J, Montaner J, Vivien D, Martinez de Lizarrondo S
Theranostics 1838-7640
PMID : 27022410
KEYWORDS : Animals|Cell-Derived Microparticles|chemistry|Disease Models, Animal|Humans|Mice|Microscopy, Confocal|methods|Peptide Hydrolases|analysis|Plasma|chemistry|Stroke|pathology
Show abstract [+]

Artificial antigen-presenting cells expressing HLA class II molecules as an effective tool for amplifying human specific memory CD4(+) T cells.
Garnier A, Hamieh M, Drouet A, Leprince J, Vivien D, Frébourg T, Le Mauff B, Latouche JB, Toutirais O
Immunol. Cell Biol. 1440-1711
PMID : 26924643
KEYWORDS : Animals|Antigen Presentation|immunology|Antigen-Presenting Cells|immunology|Artificial Cells|immunology|CD4-Positive T-Lymphocytes|cytology|Cell Proliferation|Epitopes|immunology|Histocompatibility Antigens Class II|metabolism|Humans|Immunologic Memory|Lymphocyte Activation|immunology|Mice|NIH 3T3 Cells|Peptides|metabolism|Phenotype|Tissue Donors
Show abstract [+]

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.
Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C
Brain Res. 1872-6240
PMID : 26923166
KEYWORDS : Animals|Autophagy|Endoplasmic Reticulum Stress|physiology|Humans|Nervous System Diseases|complications|Proteasome Endopeptidase Complex|metabolism|Proteostasis Deficiencies|complications|Signal Transduction|Ubiquitin|metabolism|Unfolded Protein Response|physiology
Show abstract [+]

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.
Maysami S, Wong R, Pradillo JM, Denes A, Dhungana H, Malm T, Koistinaho J, Orset C, Rahman M, Rubio M, Schwaninger M, Vivien D, Bath PM, Rothwell NJ, Allan SM
J. Cereb. Blood Flow Metab. 1559-7016
PMID : 26661169
KEYWORDS : Animals|Brain|drug effects|Brain Edema|complications|Brain Ischemia|complications|Disease Models, Animal|Drug Evaluation, Preclinical|Inflammation|complications|Interleukin 1 Receptor Antagonist Protein|therapeutic use|Male|Mice, Inbred BALB C|Mice, Inbred C57BL|Neuroprotective Agents|therapeutic use|Receptors, Interleukin-1|antagonists & inhibitors|Stroke|complications
Show abstract [+]

The story of an exceptional serine protease, tissue-type plasminogen activator (tPA).
Hébert M, Lesept F, Vivien D, Macrez R
Rev. Neurol. (Paris) 0035-3787
PMID : 26626577
KEYWORDS : Animals|Brain Chemistry|genetics|Humans|Serine Proteases|genetics|Tissue Plasminogen Activator|genetics
Show abstract [+]

The plasminogen activation system in neuroinflammation.
Mehra A, Ali C, Parcq J, Vivien D, Docagne F
Biochim. Biophys. Acta 0006-3002
PMID : 26493446
KEYWORDS : Animals|Blood-Brain Barrier|immunology|Central Nervous System Diseases|immunology|Fibrin|immunology|Fibrinolysin|immunology|Humans|Inflammation|immunology|Leukocytes|immunology|Microglia|immunology|Plasminogen|immunology|Tissue Plasminogen Activator|immunology
Show abstract [+]

Epidural Cortical Stimulation as a Treatment for Poststroke Aphasia: A Systematic Review of the Literature and Underlying Neurophysiological Mechanisms.
Balossier A, Etard O, Descat C, Vivien D, Emery E
Neurorehabil Neural Repair 1552-6844
PMID : 26422832
KEYWORDS : Aphasia, Broca|etiology|Cerebral Cortex|physiopathology|Electric Stimulation Therapy|methods|Humans|Stroke|complications
Show abstract [+]

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons.
Louessard M, Lacroix A, Martineau M, Mondielli G, Montagne A, Lesept F, Lambolez B, Cauli B, Mothet JP, Vivien D, Maubert E
Mol. Neurobiol. 1559-1182
PMID : 26377106
KEYWORDS : Animals|Cells, Cultured|Excitatory Postsynaptic Potentials|physiology|Gene Expression|Glutamic Acid|metabolism|Male|Mice|Mice, Inbred C57BL|Mice, Knockout|Organ Culture Techniques|Pyramidal Cells|metabolism|Rats|Rats, Wistar|Synaptic Vesicles|metabolism|Tissue Plasminogen Activator|biosynthesis
Show abstract [+]

Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism.
Lemarchand E, Maubert E, Haelewyn B, Ali C, Rubio M, Vivien D
Cell Death Differ. 1476-5403
PMID : 26068590
KEYWORDS : Animals|Brain Ischemia|genetics|Cell Death|genetics|Central Nervous System|metabolism|ErbB Receptors|genetics|Glucose|metabolism|Hippocampus|metabolism|Mice|Neurons|metabolism|Oxygen|metabolism|Rats|Signal Transduction|Tissue Plasminogen Activator|genetics
Show abstract [+]

Normalization of Reverse Transcription Quantitative PCR Data During Ageing in Distinct Cerebral Structures.
Bruckert G, Vivien D, Docagne F, Roussel BD
Mol. Neurobiol. 1559-1182
PMID : 25663136
KEYWORDS : Aging|genetics|Algorithms|Animals|Brain Chemistry|genetics|Cerebellum|metabolism|Cerebral Cortex|growth & development|Corpus Striatum|growth & development|Gene Expression Profiling|Hippocampus|metabolism|Male|Mice|Mice, Inbred C57BL|Nerve Tissue Proteins|biosynthesis|Reverse Transcriptase Polymerase Chain Reaction
Show abstract [+]


Impacts of tissue-type plasminogen activator (tPA) on neuronal survival.
Chevilley A, Lesept F, Lenoir S, Ali C, Parcq J, Vivien D
Front Cell Neurosci 1662-5102
PMID : 26528141
Show abstract [+]

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
Bertrand T, Lesept F, Chevilley A, Lenoir S, Aimable M, Briens A, Hommet Y, Bardou I, Parcq J, Vivien D
Cell Death Dis 2041-4889
PMID : 26469972
KEYWORDS : Apoptosis|Calcium Signaling|Cell Survival|ErbB Receptors|metabolism|Female|Humans|Protein Conformation|Receptor Cross-Talk|Receptors, N-Methyl-D-Aspartate|metabolism|Tissue Plasminogen Activator|chemistry
Show abstract [+]

Unmasking Silent Endothelial Activation in the Cardiovascular System Using Molecular Magnetic Resonance Imaging.
Belliere J, Martinez de Lizarrondo S, Choudhury RP, Quenault A, Le Béhot A, Delage C, Chauveau D, Schanstra JP, Bascands JL, Vivien D, Gauberti M
Theranostics 1838-7640
PMID : 26379785
KEYWORDS : Animals|Cardiovascular Diseases|diagnosis|Cardiovascular System|pathology|Disease Models, Animal|Endothelium, Vascular|pathology|Magnetic Resonance Imaging|methods|Mice|Molecular Imaging|methods
Show abstract [+]

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.
Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A
Sci Transl Med 1946-6242
PMID : 26246166
KEYWORDS : Acute Disease|Animals|Antibodies, Monoclonal|therapeutic use|Brain Ischemia|drug therapy|Disease Models, Animal|Drug Evaluation, Preclinical|Humans|Integrin alpha4|immunology|Mice|Random Allocation|Treatment Outcome
Show abstract [+]

Letter by Macrez et al. Regarding Article, "Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke".
Macrez R, Vivien D, Docagne F
Stroke 1524-4628
PMID : 26022638
KEYWORDS : Autoantibodies|analysis|Brain Ischemia|pathology|Female|Humans|Male|Receptors, N-Methyl-D-Aspartate|immunology|Stroke|pathology

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator.
Lemarchand E, Gauberti M, Martinez de Lizarrondo S, Villain H, Repessé Y, Montagne A, Vivien D, Ali C, Rubio M
Stroke 1524-4628
PMID : 25922513
KEYWORDS : Alcohol Drinking|adverse effects|Animals|Brain Ischemia|drug therapy|Disease Models, Animal|Liver|metabolism|Low Density Lipoprotein Receptor-Related Protein-1|metabolism|Mice|Stroke|drug therapy|Thrombolytic Therapy|Tissue Plasminogen Activator|pharmacokinetics
Show abstract [+]

Letter by Gauberti and Vivien regarding article, "amplification of regulatory T cells using a CD28 superagonist reduces brain damage after ischemic stroke in mice".
Gauberti M, Vivien D
Stroke 1524-4628
PMID : 25586834
KEYWORDS : Animals|Brain|immunology|CD28 Antigens|agonists|Infarction, Middle Cerebral Artery|immunology|T-Lymphocytes, Regulatory|immunology

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke.
Wyseure T, Rubio M, Denorme F, Martinez de Lizarrondo S, Peeters M, Gils A, De Meyer SF, Vivien D, Declerck PJ
Blood 1528-0020
PMID : 25540192
KEYWORDS : Animals|Antibodies, Bispecific|chemistry|Disease Models, Animal|Female|Fibrinolytic Agents|therapeutic use|Histone Acetyltransferases|immunology|Immunotherapy|Male|Mice|Mice, Inbred C57BL|Protein Multimerization|Serpin E2|immunology|Stroke|pathology|TATA-Binding Protein Associated Factors|immunology|Therapies, Investigational|methods|Transcription Factor TFIID|immunology|Venous Thromboembolism|pathology
Show abstract [+]

NURR1 involvement in recombinant tissue-type plasminogen activator treatment complications after ischemic stroke.
Merino-Zamorano C, Hernández-Guillamon M, Jullienne A, Le Béhot A, Bardou I, Parés M, Fernández-Cadenas I, Giralt D, Carrera C, Ribó M, Vivien D, Ali C, Rosell A, Montaner J
Stroke 1524-4628
PMID : 25503547
KEYWORDS : Aged|Aged, 80 and over|Animals|Biomarkers|blood|Brain Ischemia|blood|Cell Line|Female|Fibrinolytic Agents|adverse effects|Humans|Inflammation|blood|Male|Mice|Middle Aged|Nuclear Receptor Subfamily 4, Group A, Member 2|biosynthesis|Stroke|blood|Tissue Plasminogen Activator|adverse effects|Treatment Outcome
Show abstract [+]

Understanding the functions of endogenous and exogenous tissue-type plasminogen activator during stroke.
Docagne F, Parcq J, Lijnen R, Ali C, Vivien D
Stroke 1524-4628
PMID : 25395410
KEYWORDS : Brain|physiology|Fibrinolytic Agents|therapeutic use|Humans|Stroke|drug therapy|Thrombolytic Therapy|Tissue Plasminogen Activator|physiology

BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes.
Ollitrault D, Legendre F, Drougard C, Briand M, Benateau H, Goux D, Chajra H, Poulain L, Hartmann D, Vivien D, Shridhar V, Baldi A, Mallein-Gerin F, Boumediene K, Demoor M, Galera P
Tissue Eng Part C Methods 1937-3392
PMID : 24957638
KEYWORDS : Aged|Aged, 80 and over|Animals|Bone Morphogenetic Protein 2|pharmacology|Cartilage, Articular|cytology|Cattle|Cell Hypoxia|drug effects|Cells, Cultured|Chondrocytes|Chondrogenesis|drug effects|Collagen Type I|metabolism|Extracellular Matrix|drug effects|High-Temperature Requirement A Serine Peptidase 1|Humans|Hyalin|metabolism|Hypertrophy|Kinetics|Mice, Nude|Middle Aged|Osteogenesis|drug effects|Phenotype|RNA, Messenger|genetics|RNA, Small Interfering|metabolism|Serine Endopeptidases|metabolism
Show abstract [+]


Molecular magnetic resonance imaging of brain-immune interactions.
Gauberti M, Montagne A, Quenault A, Vivien D
Front Cell Neurosci 1662-5102
PMID : 25505871
Show abstract [+]

Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis?
Gaberel T, Gakuba C, Goulay R, Martinez De Lizarrondo S, Hanouz JL, Emery E, Touze E, Vivien D, Gauberti M
Stroke 1524-4628
PMID : 25190438
KEYWORDS : Animals|Cerebrospinal Fluid|physiology|Contrast Media|Disease Models, Animal|Image Interpretation, Computer-Assisted|Magnetic Resonance Imaging|methods|Mice|Stroke|cerebrospinal fluid|Subarachnoid Hemorrhage|cerebrospinal fluid
Show abstract [+]

Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis.
Gaberel T, Montagne A, Lesept F, Gauberti M, Lemarchand E, Orset C, Goulay R, Bertrand T, Emery E, Vivien D
Neuropharmacology 1873-7064
PMID : 24846802
KEYWORDS : Animals|Brain|drug effects|Brain Edema|drug therapy|Cells, Cultured|Cerebral Hemorrhage|drug therapy|Collagenases|Disease Models, Animal|Fibrinolysis|drug effects|Fibrinolytic Agents|pharmacology|Hematoma|drug therapy|Hydrocephalus|drug therapy|Male|Mice|Neuroimmunomodulation|drug effects|Random Allocation|Rats, Sprague-Dawley|Recovery of Function|drug effects|Tissue Plasminogen Activator|pharmacology|Urokinase-Type Plasminogen Activator|pharmacology
Show abstract [+]

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury.
Lemarchant S, Pruvost M, Hébert M, Gauberti M, Hommet Y, Briens A, Maubert E, Gueye Y, Féron F, Petite D, Mersel M, do Rego JC, Vaudry H, Koistinaho J, Ali C, Agin V, Emery E, Vivien D
Neurobiol. Dis. 1095-953X
PMID : 24576594
KEYWORDS : ADAM Proteins|metabolism|ADAMTS4 Protein|Animals|Axons|drug effects|Cells, Cultured|Chondroitin Sulfate Proteoglycans|metabolism|Female|Neurites|drug effects|Neuronal Plasticity|drug effects|Neuropeptides|pharmacology|Neuroprotective Agents|pharmacology|Plasminogen Activator Inhibitor 1|pharmacology|Procollagen N-Endopeptidase|metabolism|Rats|Rats, Wistar|Recovery of Function|Serine Proteinase Inhibitors|pharmacology|Serpins|pharmacology|Spinal Cord|drug effects|Spinal Cord Compression|drug therapy|Spinal C
Show abstract [+]

GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.
Le Behot A, Gauberti M, Martinez De Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, Guillou S, Denis CV, Maubert E, Orset C, Vivien D
Blood 1528-0020
PMID : 24553181
KEYWORDS : Animals|Benzofurans|Blood Platelets|metabolism|Blood Vessels|metabolism|Hemorheology|Male|Mice|Platelet Aggregation|Platelet Glycoprotein GPIb-IX Complex|metabolism|Protein Interaction Maps|Quinolines|Thrombosis|metabolism|von Willebrand Factor|metabolism
Show abstract [+]

Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.
Gauberti M, Martinez de Lizarrondo S, Orset C, Vivien D
J. Thromb. Haemost. 1538-7836
PMID : 24354644
KEYWORDS : Animals|Blood Coagulation|Bradykinin|metabolism|Brain Diseases|prevention & control|Cerebrovascular Circulation|Factor XII|metabolism|Inflammation|Ischemia|pathology|Macaca mulatta|Male|Mice|Mice, Inbred C57BL|Stroke|chemically induced|T-Lymphocytes|cytology|Thrombin|adverse effects|Thrombosis|pathology|von Willebrand Factor|metabolism
Show abstract [+]


Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.
Gaberel T, Gakuba C, Hebert M, Montagne A, Agin V, Rubio M, Emery E, Vivien D, Gauberti M
Stroke 1524-4628
PMID : 24105700
KEYWORDS : Animals|Brain|pathology|Intracranial Hemorrhages|blood|Magnetic Resonance Imaging|Mice|Oxygen|blood|Oxygen Inhalation Therapy|Treatment Outcome
Show abstract [+]

Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes.
Gauberti M, Montagne A, Marcos-Contreras OA, Le Béhot A, Maubert E, Vivien D
Stroke 1524-4628
PMID : 23743972
KEYWORDS : Animals|Ferric Compounds|Image Enhancement|methods|Infarction, Middle Cerebral Artery|drug therapy|Inflammation|drug therapy|Intracranial Hemorrhages|chemically induced|Magnetic Resonance Imaging|instrumentation|Mice|Vascular Cell Adhesion Molecule-1|drug effects
Show abstract [+]

Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain.
Parcq J, Bertrand T, Baron AF, Hommet Y, Anglès-Cano E, Vivien D
J. Thromb. Haemost. 1538-7836
PMID : 23301636
KEYWORDS : Amino Acid Sequence|Animals|Bioengineering|instrumentation|Bioreactors|Cell Death|drug effects|Drug Design|Fibrinolysis|drug effects|Fibrinolytic Agents|metabolism|HEK293 Cells|Humans|Kringles|Mice|Molecular Sequence Data|Mutagenesis, Site-Directed|Neurons|drug effects|Neurotoxicity Syndromes|etiology|Point Mutation|Rats|Receptors, N-Methyl-D-Aspartate|drug effects|Recombinant Proteins|pharmacology|Structure-Activity Relationship|Thrombolytic Therapy|adverse effects|Tissue Plasminogen Activator|biosynthesis
Show abstract [+]

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome.
Gaberel T, Macrez R, Gauberti M, Montagne A, Hebert M, Petersen KU, Touze E, Agin V, Emery E, Ali C, Vivien D
Neuropharmacology 1873-7064
PMID : 23219658
KEYWORDS : Animals|Antibodies, Monoclonal, Murine-Derived|administration & dosage|Immunotherapy|methods|Intracranial Hemorrhages|immunology|Male|Mice|Random Allocation|Rats|Rats, Sprague-Dawley|Receptors, N-Methyl-D-Aspartate|metabolism|Stroke|immunology|Tissue Plasminogen Activator|antagonists & inhibitors|Treatment Outcome
Show abstract [+]

Epidural electrical stimulation for the treatment of chronic poststroke aphasia: still compulsory 6 years later!
Balossier A, Etard O, Descat C, Vivien D, Emery E
Br J Neurosurg 1360-046X
PMID : 22998751
KEYWORDS : Aphasia, Broca|etiology|Electric Stimulation Therapy|methods|Electrodes, Implanted|Female|Humans|Middle Aged|Stroke|complications
Show abstract [+]


GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory.
Obiang P, Macrez R, Jullienne A, Bertrand T, Lesept F, Ali C, Maubert E, Vivien D, Agin V
J. Neurosci. 1529-2401
PMID : 22972996
KEYWORDS : Animals|Glutamic Acid|metabolism|Male|Maze Learning|physiology|Memory, Short-Term|physiology|Mice|Mice, Knockout|Mice, Transgenic|Protein Subunits|Receptors, N-Methyl-D-Aspartate|metabolism|Space Perception|physiology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Memantine improves safety of thrombolysis for stroke.
Montagne A, Hébert M, Jullienne A, Lesept F, Le Béhot A, Louessard M, Gauberti M, Orset C, Ali C, Agin V, Maubert E, Vivien D
Stroke 1524-4628
PMID : 22879098
KEYWORDS : Animals|Cells, Cultured|Cerebral Cortex|drug effects|Chemotherapy, Adjuvant|Excitatory Amino Acid Antagonists|pharmacology|Fibrinolytic Agents|adverse effects|In Vitro Techniques|Magnetic Resonance Imaging|Male|Memantine|pharmacology|Mice|Models, Animal|N-Methylaspartate|pharmacology|Stroke|drug therapy|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|adverse effects|Treatment Outcome
Show abstract [+]

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders.
Montagne A, Gauberti M, Macrez R, Jullienne A, Briens A, Raynaud JS, Louin G, Buisson A, Haelewyn B, Docagne F, Defer G, Vivien D, Maubert E
Neuroimage 1095-9572
PMID : 22813950
KEYWORDS : Animals|Blotting, Western|Central Nervous System Diseases|diagnosis|Endothelial Cells|metabolism|Ferric Compounds|Immunohistochemistry|Magnetic Resonance Imaging|methods|Male|Metal Nanoparticles|Mice|Mice, Inbred C57BL|Molecular Imaging|methods|Real-Time Polymerase Chain Reaction|Reverse Transcriptase Polymerase Chain Reaction
Show abstract [+]

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.
Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E, Vivien D
Cell Death Differ. 1476-5403
PMID : 22743997
KEYWORDS : Animals|Calcium|metabolism|Cells, Cultured|Humans|Mice|Mitogen-Activated Protein Kinase 1|metabolism|Mitogen-Activated Protein Kinase 3|metabolism|N-Methylaspartate|toxicity|Neurons|drug effects|Receptors, N-Methyl-D-Aspartate|metabolism|Recombinant Proteins|genetics|Signal Transduction|drug effects|Tissue Plasminogen Activator|genetics
Show abstract [+]

Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
Cassé F, Bardou I, Danglot L, Briens A, Montagne A, Parcq J, Alahari A, Galli T, Vivien D, Docagne F
J. Neurosci. 1529-2401
PMID : 22496564
KEYWORDS : Albumins|metabolism|Animals|Astrocytes|drug effects|Cell Death|drug effects|Cells, Cultured|Clathrin|physiology|Dynamins|physiology|Endocytosis|drug effects|Flow Cytometry|Gene Silencing|Glutamic Acid|pharmacology|Immunohistochemistry|Mice|Neurons|drug effects|Plasmids|genetics|Protein Kinase C|metabolism|RNA|biosynthesis|Real-Time Polymerase Chain Reaction|Receptors, Kainic Acid|drug effects|Receptors, LDL|metabolism|Signal Transduction|drug effects|Synapsins|metabolism|Tissue Plasminogen Activator|metabol
Show abstract [+]

Thrombotic stroke in the anesthetized monkey (Macaca mulatta): characterization by MRI--a pilot study.
Gauberti M, Obiang P, Guedin P, Balossier A, Gakuba C, Diependaele AS, Chazalviel L, Vivien D, Young AR, Agin V, Orset C
Cerebrovasc. Dis. 1421-9786
PMID : 22343114
KEYWORDS : Anesthesia|Anesthetics, Dissociative|Anesthetics, Inhalation|Animals|Atracurium|Craniotomy|Diffusion Magnetic Resonance Imaging|methods|Disease Models, Animal|Image Processing, Computer-Assisted|Infarction, Middle Cerebral Artery|complications|Ketamine|Macaca mulatta|Magnetic Resonance Angiography|methods|Magnetic Resonance Imaging|Male|Methyl Ethers|Neurologic Examination|Neuromuscular Nondepolarizing Agents|Nitrous Oxide|Pilot Projects|Reproducibility of Results|Sevoflurane|Stroke|etiology|Thromboembolism
Show abstract [+]

tPA in the injured central nervous system: different scenarios starring the same actor?
Lemarchant S, Docagne F, Emery E, Vivien D, Ali C, Rubio M
Neuropharmacology 1873-7064
PMID : 22079561
KEYWORDS : Brain Ischemia|metabolism|Central Nervous System|metabolism|Humans|Multiple Sclerosis|metabolism|Spinal Cord Injuries|metabolism|Stroke|metabolism|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Epidural electrical stimulation to improve chronic poststroke aphasia: a 5-year follow-up.
Balossier A, Etard O, Descat C, Vivien D, Emery E
Brain Stimul 1876-4754
PMID : 22037142
KEYWORDS : Aphasia|etiology|Electric Stimulation Therapy|methods|Epidural Space|Female|Follow-Up Studies|Humans|Middle Aged|Stroke|complications|Stroke Rehabilitation|Treatment Outcome
Show abstract [+]


Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo.
Jullienne A, Montagne A, Orset C, Lesept F, Jane DE, Monaghan DT, Maubert E, Vivien D, Ali C
Mol Neurodegener 1750-1326
PMID : 21975018
Show abstract [+]

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.
Rubio M, Villain H, Docagne F, Roussel BD, Ramos JA, Vivien D, Fernandez-Ruiz J, Ali C
PLoS ONE 1932-6203
PMID : 21886913
KEYWORDS : Animals|Cannabinoids|agonists|Cell Death|drug effects|Cells, Cultured|Ethanol|pharmacology|Excitatory Amino Acid Agonists|pharmacology|Mice|N-Methylaspartate|analysis|Neurons|Neuroprotective Agents|Piperidines|pharmacology|Pyrazoles|pharmacology|Receptor, Cannabinoid, CB1|antagonists & inhibitors|Rimonabant|Substance Withdrawal Syndrome
Show abstract [+]

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.
Vivien D, Gauberti M, Montagne A, Defer G, Touzé E
J. Cereb. Blood Flow Metab. 1559-7016
PMID : 21878948
KEYWORDS : Acute Disease|Aging|pathology|Animals|Blood-Brain Barrier|drug effects|Brain|blood supply|Drug Administration Schedule|Fibrinolytic Agents|administration & dosage|Humans|Microvessels|drug effects|Stroke|drug therapy|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Intraventricular fibrinolysis versus external ventricular drainage alone in intraventricular hemorrhage: a meta-analysis.
Gaberel T, Magheru C, Parienti JJ, Huttner HB, Vivien D, Emery E
Stroke 1524-4628
PMID : 21817146
KEYWORDS : Cerebral Hemorrhage|drug therapy|Cerebral Ventricles|surgery|Drainage|methods|Fibrinolytic Agents|therapeutic use|Humans|Injections, Intraventricular|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
Show abstract [+]

Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation.
Gakuba C, Gauberti M, Mazighi M, Defer G, Hanouz JL, Vivien D
Stroke 1524-4628
PMID : 21817137
KEYWORDS : Anesthetics, Dissociative|therapeutic use|Animals|Brain Ischemia|drug therapy|Fibrinolytic Agents|therapeutic use|Ketamine|therapeutic use|Magnetic Resonance Imaging|Male|Mice|Stroke|drug therapy|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|therapeutic use|Treatment Outcome
Show abstract [+]

Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis.
Macrez R, Obiang P, Gauberti M, Roussel B, Baron A, Parcq J, Cassé F, Hommet Y, Orset C, Agin V, Bezin L, Berrocoso TG, Petersen KU, Montaner J, Maubert E, Vivien D, Ali C
Stroke 1524-4628
PMID : 21680906
KEYWORDS : Animals|Antibodies|immunology|Brain|drug effects|Brain Ischemia|drug therapy|Fibrinolytic Agents|immunology|Mice|Receptors, N-Methyl-D-Aspartate|immunology|Stroke|drug therapy|Tissue Plasminogen Activator|immunology
Show abstract [+]

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator.
Roussel BD, Mysiorek C, Rouhiainen A, Jullienne A, Parcq J, Hommet Y, Culot M, Berezowski V, Cecchelli R, Rauvala H, Vivien D, Ali C
J. Cell. Sci. 1477-9137
PMID : 21610098
KEYWORDS : Animals|Biomarkers|blood|Blood-Brain Barrier|cytology|Calcium|metabolism|Cattle|Cells, Cultured|Coculture Techniques|Fibrinolysis|drug effects|HMG-Box Domains|HMGB1 Protein|metabolism|Humans|Mice|N-Methylaspartate|pharmacology|Neurons|drug effects|Neuroprotective Agents|pharmacology|Rats|Rats, Sprague-Dawley|Recombinant Proteins|pharmacology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Tissue plasminogen activator prevents white matter damage following stroke.
Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P, Hernangómez M, Montagne A, Liot G, Guaza C, Maubert E, Ali C, Vivien D, Docagne F
J. Exp. Med. 1540-9538
PMID : 21576385
KEYWORDS : Aging|Animals|Apoptosis|Brain|pathology|Brain Injuries|pathology|Caspase 3|metabolism|Cell Lineage|Cytokines|metabolism|Endothelium, Vascular|cytology|Epidermal Growth Factor|chemistry|Extracellular Signal-Regulated MAP Kinases|metabolism|Humans|Mice|Mice, Inbred C57BL|Oligodendroglia|cytology|Stroke|pathology|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Stroke and the immune system: from pathophysiology to new therapeutic strategies.
Macrez R, Ali C, Toutirais O, Le Mauff B, Defer G, Dirnagl U, Vivien D
Lancet Neurol 1474-4465
PMID : 21511199
KEYWORDS : Animals|Brain|drug effects|Brain Diseases|immunology|Humans|Immunologic Factors|therapeutic use|Stroke|immunology
Show abstract [+]

Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF.
Obiang P, Maubert E, Bardou I, Nicole O, Launay S, Bezin L, Vivien D, Agin V
Neurobiol Learn Mem 1095-9564
PMID : 21440650
KEYWORDS : Aging|physiology|Animals|Association Learning|physiology|Behavior, Animal|physiology|Brain|physiology|Brain-Derived Neurotrophic Factor|metabolism|Conditioning (Psychology)|physiology|Environment|Fear|physiology|Female|Housing, Animal|Memory|physiology|Mice|Neurons|physiology|Tissue Plasminogen Activator|metabolism
Show abstract [+]


Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke.
Macrez R, Bezin L, Le Mauff B, Ali C, Vivien D
Stroke 1524-4628
PMID : 20966414
KEYWORDS : Animals|Autoantibodies|biosynthesis|Immunization|Immunohistochemistry|Mice|Nerve Tissue Proteins|biosynthesis|Receptors, N-Methyl-D-Aspartate|genetics|Recombinant Proteins|biosynthesis|Stroke|drug therapy|Thrombin|pharmacology|Thrombolytic Therapy|Tissue Plasminogen Activator|immunology
Show abstract [+]

Plasmin on adherent cells: from microvesiculation to apoptosis.
Doeuvre L, Plawinski L, Goux D, Vivien D, Anglés-Cano E
Biochem. J. 1470-8728
PMID : 20846121
KEYWORDS : Animals|Apoptosis|Blood Platelets|cytology|Blotting, Western|CHO Cells|Cell Adhesion|physiology|Cell Survival|physiology|Cricetinae|Cricetulus|Fibrinolysin|biosynthesis|Humans|In Situ Nick-End Labeling|Kinetics|Microscopy, Electron|Plasminogen|chemistry|Tissue Plasminogen Activator|physiology
Show abstract [+]

Tissue-type plasminogen activator induces plasmin-dependent proteolysis of intracellular neuronal nitric oxide synthase.
Baron A, Hommet Y, Cassé F, Vivien D
Biol. Cell 1768-322X
PMID : 20636282
KEYWORDS : Animals|Fibrinolysin|metabolism|Mice|N-Methylaspartate|metabolism|Neurons|enzymology|Nitric Oxide Synthase Type I|metabolism|Signal Transduction|Tissue Plasminogen Activator|metabolism
Show abstract [+]

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
Baron A, Montagne A, Cassé F, Launay S, Maubert E, Ali C, Vivien D
Cell Death Differ. 1476-5403
PMID : 19911010
KEYWORDS : Animals|Cells, Cultured|Diazonium Compounds|pharmacology|Fibrinolytic Agents|pharmacology|Immunoblotting|Immunohistochemistry|Mice|Neurons|drug effects|Potassium Chloride|pharmacology|Pyridines|pharmacology|RNA Interference|Receptors, N-Methyl-D-Aspartate|genetics|Reverse Transcriptase Polymerase Chain Reaction|Tissue Plasminogen Activator|pharmacology
Show abstract [+]


[Cerebral ischemia (2), How to neutralize the neurotoxic effects of tPA].
Vivien D, Gauberti M, Guedin P, Anglés-Cano E,
Med Sci (Paris) 0767-0974
PMID : 19849989
KEYWORDS : Amino Acid Sequence|Blood-Brain Barrier|Brain Ischemia|drug therapy|Humans|Molecular Sequence Data|Neurotoxins|toxicity|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|chemistry

[Cellular microparticles, potential useful biomarkers in the identification of cerebrovascular accidents].
Anglés-Cano E, Vivien D,
Med Sci (Paris) 0767-0974
PMID : 19849987
KEYWORDS : Biomarkers|blood|Blood Coagulation|Cell-Derived Microparticles|metabolism|Fibrinolysis|Humans|Metalloproteases|blood|Stroke|blood
Show abstract [+]

Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Roussel BD, Macrez R, Jullienne A, Agin V, Maubert E, Dauphinot L, Potier MC, Plawinski L, Castel H, Hommet Y, Munuera J, Montaner J, Yepes M, Ali C, Vivien D
Brain 1460-2156
PMID : 19574439
KEYWORDS : Aged|Aged, 80 and over|Aging|metabolism|Animals|Brain|metabolism|Brain Ischemia|metabolism|Cell Death|drug effects|DNA-Binding Proteins|genetics|Disease Models, Animal|Female|Gene Knockdown Techniques|methods|Humans|Magnetic Resonance Imaging|methods|Mice|Mice, Inbred C57BL|Middle Aged|N-Methylaspartate|toxicity|Neurons|drug effects|Reverse Transcriptase Polymerase Chain Reaction|methods|Tissue Plasminogen Activator|metabolism|Transcription Factors|genetics
Show abstract [+]

Distribution of oxytocin-like and vasopressin-like immunoreactivities within the central nervous system of the cuttlefish, Sepia officinalis.
Bardou I, Maubert E, Leprince J, Chichery R, Cocquerelle C, Launay S, Vivien D, Vaudry H, Agin V
Cell Tissue Res. 1432-0878
PMID : 19259702
KEYWORDS : Amino Acid Sequence|Animals|Central Nervous System|anatomy & histology|Mice|Molecular Sequence Data|Nerve Fibers|metabolism|Oxytocin|chemistry|Sepia|metabolism|Vasopressins|chemistry
Show abstract [+]


HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.
Launay S, Maubert E, Lebeurrier N, Tennstaedt A, Campioni M, Docagne F, Gabriel C, Dauphinot L, Potier MC, Ehrmann M, Baldi A, Vivien D
Cell Death Differ. 1350-9047
PMID : 18551132
KEYWORDS : Animals|Brain|embryology|Cell Survival|Cells, Cultured|High-Temperature Requirement A Serine Peptidase 1|Mice|Mice, Transgenic|Neurons|cytology|Serine Endopeptidases|metabolism|Signal Transduction|Transforming Growth Factor beta1|metabolism|Up-Regulation
Show abstract [+]

Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity.
Lopez-Atalaya JP, Roussel BD, Levrat D, Parcq J, Nicole O, Hommet Y, Benchenane K, Castel H, Leprince J, To Van D, Bureau R, Rault S, Vaudry H, Petersen KU, Santos JS, Ali C, Vivien D
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 18334994
KEYWORDS : Amino Acid Sequence|Animals|Catalytic Domain|Cells, Cultured|Drug-Related Side Effects and Adverse Reactions|Fibrinolytic Agents|toxicity|Mice|Models, Molecular|Molecular Sequence Data|Neurons|drug effects|Plasminogen Activators|metabolism|Protein Binding|Protein Structure, Quaternary|Receptors, N-Methyl-D-Aspartate|chemistry|Signal Transduction|Stroke|metabolism|Tissue Culture Techniques|Tissue Plasminogen Activator|chemistry
Show abstract [+]


Neuroprotection and stroke: time for a compromise.
Young AR, Ali C, Duretête A, Vivien D
J. Neurochem. 1471-4159
PMID : 17727635
KEYWORDS : Animals|Clinical Trials as Topic|trends|Humans|Neuroprotective Agents|therapeutic use|Stroke|drug therapy|Thrombolytic Therapy|methods
Show abstract [+]

Mouse model of in situ thromboembolic stroke and reperfusion.
Orset C, Macrez R, Young AR, Panthou D, Angles-Cano E, Maubert E, Agin V, Vivien D
Stroke 1524-4628
PMID : 17702959
KEYWORDS : Animals|Cerebral Infarction|chemically induced|Cerebrovascular Circulation|drug effects|Disease Models, Animal|Fibrinolytic Agents|pharmacology|Intracranial Embolism|chemically induced|Laser-Doppler Flowmetry|Male|Mice|Motor Activity|Reperfusion|Reproducibility of Results|Thrombin|Tissue Plasminogen Activator|pharmacology
Show abstract [+]

Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms.
Cacquevel M, Launay S, Castel H, Benchenane K, Chéenne S, Buée L, Moons L, Delacourte A, Carmeliet P, Vivien D
Neurobiol. Dis. 0969-9961
PMID : 17566751
KEYWORDS : Aging|physiology|Alzheimer Disease|enzymology|Amyloid beta-Peptides|metabolism|Animals|Brain|enzymology|Enzyme-Linked Immunosorbent Assay|Humans|Immunohistochemistry|Mice|Mice, Transgenic|RNA, Messenger|analysis|Reverse Transcriptase Polymerase Chain Reaction|Tissue Plasminogen Activator|metabolism
Show abstract [+]

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects.
López-Atalaya JP, Roussel BD, Ali C, Maubert E, Petersen KU, Berezowski V, Cecchelli R, Orset C, Vivien D
Stroke 1524-4628
PMID : 17325305
KEYWORDS : Animals|Blood-Brain Barrier|drug effects|Cattle|Cells, Cultured|Chiroptera|Coculture Techniques|Fibrinolytic Agents|pharmacokinetics|Humans|Low Density Lipoprotein Receptor-Related Protein-1|physiology|Male|Plasminogen Activators|pharmacokinetics|Rats|Rats, Sprague-Dawley|Recombinant Proteins|pharmacokinetics
Show abstract [+]

Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory.
Benchenane K, Castel H, Boulouard M, Bluthé R, Fernandez-Monreal M, Roussel BD, Lopez-Atalaya JP, Butt-Gueulle S, Agin V, Maubert E, Dantzer R, Touzani O, Dauphin F, Vivien D, Ali C
J. Cell. Sci. 0021-9533
PMID : 17244650
KEYWORDS : Animals|Behavior, Animal|drug effects|Excitatory Amino Acid Agonists|pharmacology|Female|Maze Learning|drug effects|Memory|drug effects|Mice|Models, Immunological|N-Methylaspartate|pharmacology|Protein Structure, Tertiary|Receptors, N-Methyl-D-Aspartate|chemistry|Tissue Plasminogen Activator|deficiency|Vaccination
Show abstract [+]


Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity.
Liot G, Roussel BD, Lebeurrier N, Benchenane K, López-Atalaya JP, Vivien D, Ali C
J. Neurochem. 0022-3042
PMID : 16800849
KEYWORDS : Analysis of Variance|Animals|Apoptosis|drug effects|Blotting, Western|methods|Butadienes|pharmacology|Cell Count|methods|Cerebral Cortex|cytology|Chromones|pharmacology|Dose-Response Relationship, Drug|Drug Administration Schedule|Drug Interactions|Embryo, Mammalian|Enzyme Inhibitors|Fibrinolytic Agents|pharmacology|Immunohistochemistry|methods|Mice|Morpholines|pharmacology|Neurons|drug effects|Neuropeptides|pharmacology|Nitriles|pharmacology|Nuclear Proteins|pharmacology|Serpins|pharmacology|Serum|physiolo
Show abstract [+]


The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.
Lebeurrier N, Liot G, Lopez-Atalaya JP, Orset C, Fernandez-Monreal M, Sonderegger P, Ali C, Vivien D
Mol. Cell. Neurosci. 1044-7431
PMID : 16209928
KEYWORDS : Animals|Apoptosis|drug effects|Brain|drug effects|Brain Ischemia|drug therapy|Calcium Signaling|drug effects|Cells, Cultured|Cerebral Cortex|drug effects|Corpus Striatum|drug effects|Disease Models, Animal|Male|Mice|N-Methylaspartate|antagonists & inhibitors|Neurons|drug effects|Neuropeptides|metabolism|Neuroprotective Agents|metabolism|Neurotoxins|antagonists & inhibitors|Receptors, N-Methyl-D-Aspartate|drug effects|Serpins|metabolism|Stroke|metabolism
Show abstract [+]

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis.
Benchenane K, Berezowski V, Ali C, Fernández-Monreal M, López-Atalaya JP, Brillault J, Chuquet J, Nouvelot A, MacKenzie ET, Bu G, Cecchelli R, Touzani O, Vivien D
Circulation 1524-4539
PMID : 15851587
KEYWORDS : Animals|Blood-Brain Barrier|metabolism|Brain|drug effects|Cold Temperature|Low Density Lipoprotein Receptor-Related Protein-1|metabolism|Male|N-Methylaspartate|administration & dosage|Neurotoxicity Syndromes|etiology|Plasminogen Activator Inhibitor 1|administration & dosage|Protein Transport|Rats|Rats, Sprague-Dawley|Tissue Plasminogen Activator|adverse effects
Show abstract [+]

Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process.
Benchenane K, Berezowski V, Fernández-Monreal M, Brillault J, Valable S, Dehouck MP, Cecchelli R, Vivien D, Touzani O, Ali C
Stroke 1524-4628
PMID : 15817895
KEYWORDS : Animals|Blood-Brain Barrier|metabolism|Brain Ischemia|etiology|Cell Hypoxia|Cytoplasmic Vesicles|chemistry|Endothelium, Vascular|cytology|Glucose|physiology|Infarction, Middle Cerebral Artery|complications|LDL-Receptor Related Proteins|antagonists & inhibitors|Male|Mice|Protein Transport|Tissue Plasminogen Activator|analysis
Show abstract [+]

Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
Lesné S, Gabriel C, Nelson DA, White E, Mackenzie ET, Vivien D, Buisson A
J. Biol. Chem. 0021-9258
PMID : 15797869
KEYWORDS : Amyloid beta-Peptides|toxicity|Animals|Apoptosis|Blotting, Western|Brain|metabolism|Caspase 3|Caspase 8|Caspase 9|Caspases|metabolism|Cells, Cultured|Chromones|pharmacology|DNA|chemistry|Densitometry|Dose-Response Relationship, Drug|Electrophoresis, Agar Gel|methods|Enzyme Activation|Enzyme Inhibitors|pharmacology|Immunohistochemistry|Immunoprecipitation|Mice|Microscopy, Fluorescence|Morpholines|pharmacology|Nerve Tissue Proteins|metabolism|Neuronal Apoptosis-Inhibitory Protein|Neurons|metabolism|Phosphatid
Show abstract [+]


2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo.
Liot G, Benchenane K, Léveillé F, López-Atalaya JP, Fernández-Monreal M, Ruocco A, Mackenzie ET, Buisson A, Ali C, Vivien D
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 15529015
KEYWORDS : Animals|Brain Ischemia|drug therapy|Cell Death|drug effects|Cells, Cultured|Cycloheptanes|Excitatory Amino Acid Agonists|toxicity|In Vitro Techniques|Male|Mice|N-Methylaspartate|toxicity|Neurons|cytology|Neurotoxins|toxicity|Rats|Rats, Sprague-Dawley|Serine Proteinase Inhibitors|pharmacology|Signal Transduction|drug effects|Tissue Plasminogen Activator|antagonists & inhibitors
Show abstract [+]

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.
Fernández-Monreal M, López-Atalaya JP, Benchenane K, Cacquevel M, Dulin F, Le Caer JP, Rossier J, Jarrige AC, Mackenzie ET, Colloc'h N, Ali C, Vivien D
J. Biol. Chem. 0021-9258
PMID : 15448144
KEYWORDS : Alanine|chemistry|Amino Acid Sequence|Animals|Arginine|chemistry|Binding Sites|Calcium|chemistry|Cell Line|Humans|Immunoblotting|Kinetics|Ligands|Mass Spectrometry|Mice|Microscopy, Video|Models, Molecular|Molecular Sequence Data|Mutagenesis, Site-Directed|Mutation|Neurons|metabolism|Point Mutation|Protein Binding|Protein Conformation|Protein Structure, Tertiary|Receptors, N-Methyl-D-Aspartate|chemistry|Recombinant Proteins|chemistry|Sequence Homology, Amino Acid|Signal Transduction|Spectrometry, Mass, Matri
Show abstract [+]

Cytokines in neuroinflammation and Alzheimer's disease.
Cacquevel M, Lebeurrier N, Chéenne S, Vivien D
Curr Drug Targets 1389-4501
PMID : 15270199
KEYWORDS : Alzheimer Disease|metabolism|Brain|cytology|Cytokines|chemistry|Humans|Inflammation|metabolism|Models, Biological|Transforming Growth Factor beta|chemistry
Show abstract [+]

The complexity of tissue-type plasminogen activator: can serine protease inhibitors help in stroke management?
Lebeurrier N, Vivien D, Ali C
Expert Opin. Ther. Targets 1744-7631
PMID : 15268626
KEYWORDS : Animals|Disease Management|Humans|Serine Proteinase Inhibitors|administration & dosage|Stroke|drug therapy|Time Factors|Tissue Plasminogen Activator|administration & dosage
Show abstract [+]

Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.
Docagne F, Gabriel C, Lebeurrier N, Lesné S, Hommet Y, Plawinski L, Mackenzie ET, Vivien D
Biochem. J. 1470-8728
PMID : 15242331
KEYWORDS : Alzheimer Disease|genetics|Amyloid beta-Protein Precursor|genetics|Animals|Base Sequence|Cell Line|DNA-Binding Proteins|metabolism|Mink|Multiprotein Complexes|metabolism|Mutation|genetics|Protein Binding|drug effects|Response Elements|genetics|Signal Transduction|drug effects|Smad Proteins|Smad3 Protein|Smad4 Protein|Sp1 Transcription Factor|metabolism|Sp3 Transcription Factor|Trans-Activators|metabolism|Transcription Factors|metabolism|Transcription, Genetic|drug effects|Transcriptional Activation|drug eff
Show abstract [+]

Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis.
Liot G, Gabriel C, Cacquevel M, Ali C, MacKenzie ET, Buisson A, Vivien D
Exp. Neurol. 0014-4886
PMID : 15081586
KEYWORDS : Animals|Apoptosis|drug effects|Cells, Cultured|Cerebral Cortex|cytology|Culture Media, Serum-Free|pharmacology|Enzyme Inhibitors|pharmacology|MAP Kinase Signaling System|drug effects|Mice|Neurons|cytology|Neuroprotective Agents|pharmacology|Neurotrophin 3|pharmacology|Phosphatidylinositol 3-Kinases|antagonists & inhibitors|Protein-Serine-Threonine Kinases|Proto-Oncogene Proteins|metabolism|Proto-Oncogene Proteins c-akt|Signal Transduction|drug effects
Show abstract [+]

Is tissue-type plasminogen activator a neuromodulator?
Fernández-Monreal M, López-Atalaya JP, Benchenane K, Léveillé F, Cacquevel M, Plawinski L, MacKenzie ET, Bu G, Buisson A, Vivien D
Mol. Cell. Neurosci. 1044-7431
PMID : 15080889
KEYWORDS : Action Potentials|drug effects|Animals|Brain|metabolism|Brain Chemistry|physiology|Calcium Signaling|drug effects|Cell Line|Cerebral Cortex|cytology|Chelating Agents|pharmacology|Exocytosis|drug effects|Glial Fibrillary Acidic Protein|metabolism|Humans|Low Density Lipoprotein Receptor-Related Protein-1|metabolism|Mice|Microtubule-Associated Proteins|metabolism|N-Methylaspartate|pharmacology|Neurons|drug effects|Neurotransmitter Agents|metabolism|Receptors, N-Methyl-D-Aspartate|agonists|Synaptic Transmission
Show abstract [+]

Equivocal roles of tissue-type plasminogen activator in stroke-induced injury.
Benchenane K, López-Atalaya JP, Fernández-Monreal M, Touzani O, Vivien D
Trends Neurosci. 0166-2236
PMID : 15036881
KEYWORDS : Animals|Cell Death|drug effects|Disease Models, Animal|Fibrinolytic Agents|adverse effects|Glutamic Acid|metabolism|Humans|Neuroglia|drug effects|Neurons|drug effects|Neuroprotective Agents|adverse effects|Signal Transduction|drug effects|Stroke|complications|Thrombolytic Therapy|methods|Tissue Plasminogen Activator|adverse effects|Transforming Growth Factor beta|therapeutic use|Transforming Growth Factor beta1
Show abstract [+]


Transforming growth factor-beta and ischemic brain injury.
Buisson A, Lesne S, Docagne F, Ali C, Nicole O, MacKenzie ET, Vivien D
Cell. Mol. Neurobiol. 0272-4340
PMID : 14514014
KEYWORDS : Animals|Apoptosis|drug effects|Brain Infarction|drug therapy|Brain Ischemia|drug therapy|Carrier Proteins|metabolism|Humans|Mitogen-Activated Protein Kinases|metabolism|Neuroprotective Agents|metabolism|Plasminogen Activator Inhibitor 1|metabolism|Transforming Growth Factor beta|metabolism|Transforming Growth Factor beta1|bcl-Associated Death Protein
Show abstract [+]

[Does transforming growth factor-beta (TGF-beta) act as a neuroprotective agent in cerebral ischemia?].
Docagne F, Ali C, Lesne S, Nicole O, MacKenzie ET, Buisson A, Vivien D
J. Soc. Biol. 1295-0661
PMID : 12910629
KEYWORDS : Animals|Astrocytes|physiology|Brain Ischemia|genetics|Cell Death|drug effects|Gene Expression Regulation|Humans|Neuroprotective Agents|pharmacology|Plasminogen Activator Inhibitor 1|genetics|Transforming Growth Factor beta|pharmacology
Show abstract [+]

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.
Lesné S, Docagne F, Gabriel C, Liot G, Lahiri DK, Buée L, Plawinski L, Delacourte A, MacKenzie ET, Buisson A, Vivien D
J. Biol. Chem. 0021-9258
PMID : 12626500
KEYWORDS : Alzheimer Disease|metabolism|Amyloid beta-Peptides|chemistry|Amyloid beta-Protein Precursor|genetics|Animals|Astrocytes|cytology|Base Sequence|Blotting, Western|Cell Nucleus|metabolism|Cells, Cultured|Culture Media, Conditioned|pharmacology|Densitometry|Enzyme-Linked Immunosorbent Assay|Genes, Reporter|Humans|Immunoblotting|Immunohistochemistry|Luciferases|metabolism|Mice|Mice, Inbred BALB C|Mice, Transgenic|Microglia|metabolism|Microscopy, Fluorescence|Molecular Sequence Data|Neurons|metabolism|Promoter Re
Show abstract [+]

Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.
Valable S, Bellail A, Lesné S, Liot G, Mackenzie ET, Vivien D, Bernaudin M, Petit E
FASEB J. 1530-6860
PMID : 12514118
KEYWORDS : Angiogenesis Inducing Agents|pharmacology|Angiopoietin-1|Animals|Apoptosis|Cells, Cultured|Chromones|pharmacology|Culture Media, Serum-Free|Enzyme Activation|Enzyme Inhibitors|pharmacology|Membrane Glycoproteins|pharmacology|Mice|Models, Biological|Morpholines|pharmacology|Neoplasm Proteins|analysis|Neurons|cytology|Neuroprotective Agents|pharmacology|Phosphatidylinositol 3-Kinases|antagonists & inhibitors|Proto-Oncogene Proteins|Receptor, TIE-2
Show abstract [+]

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.
Gabriel C, Ali C, Lesné S, Fernández-Monreal M, Docagne F, Plawinski L, MacKenzie ET, Buisson A, Vivien D
FASEB J. 1530-6860
PMID : 12490542
KEYWORDS : Animals|Apoptosis|drug effects|Astrocytes|cytology|Dose-Response Relationship, Drug|Gene Expression Regulation|drug effects|Mitogen-Activated Protein Kinases|drug effects|N-Methylaspartate|pharmacology|Neurons|cytology|Phosphorylation|drug effects|Plasminogen Activator Inhibitor 1|genetics|RNA, Messenger|drug effects|Tissue Plasminogen Activator|drug effects|Transforming Growth Factor alpha|pharmacology
Show abstract [+]


Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis.
Docagne F, Nicole O, Gabriel C, Fernández-Monreal M, Lesné S, Ali C, Plawinski L, Carmeliet P, MacKenzie ET, Buisson A, Vivien D
Mol. Cell. Neurosci. 1044-7431
PMID : 12504596
KEYWORDS : Animals|Animals, Newborn|Astrocytes|drug effects|Brain|drug effects|Calcium Signaling|drug effects|Cells, Cultured|Coculture Techniques|DNA-Binding Proteins|drug effects|Dose-Response Relationship, Drug|Excitatory Amino Acid Antagonists|pharmacology|Fetus|Mice|N-Methylaspartate|antagonists & inhibitors|Nerve Degeneration|chemically induced|Neurons|drug effects|Neuroprotective Agents|metabolism|Neurotoxins|antagonists & inhibitors|Plasminogen Activator Inhibitor 1|genetics|Recombinant Fusion Proteins|Smad3 P
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Matching gene expression with hypometabolism after cerebral ischemia in the nonhuman primate.
Chuquet J, Benchenane K, Liot G, Fernández-Monreal M, Toutain J, Blanchet S, Eveno E, Auffray C, Piétu G, Buisson A, Touzani O, MacKenzie ET, Vivien D
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 12368653
KEYWORDS : Animals|Brain|blood supply|Brain Ischemia|genetics|Cerebral Arteries|metabolism|Cloning, Molecular|Cluster Analysis|DNA, Complementary|Disease Models, Animal|Gene Expression Regulation|Male|Oligonucleotide Array Sequence Analysis|Oxygen Consumption|Papio
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Transforming growth factor-beta1-modulated cerebral gene expression.
Lesné S, Blanchet S, Docagne F, Liot G, Plawinski L, MacKenzie ET, Auffray C, Buisson A, Piétu G, Vivien D
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 12218417
KEYWORDS : Animals|Animals, Newborn|Astrocytes|metabolism|Base Sequence|Cells, Cultured|Cerebral Cortex|metabolism|DNA Primers|Gene Expression Regulation|physiology|Glial Fibrillary Acidic Protein|genetics|Humans|Mice|Mice, Transgenic|Nerve Tissue Proteins|genetics|Neurons|metabolism|Oligonucleotide Array Sequence Analysis|Promoter Regions, Genetic|RNA, Messenger|genetics|Transcription, Genetic|Transforming Growth Factor beta|physiology|Transforming Growth Factor beta1
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A soluble transforming growth factor-beta (TGF-beta ) type I receptor mimics TGF-beta responses.
Docagne F, Colloc'h N, Bougueret V, Page M, Paput J, Tripier M, Dutartre P, MacKenzie ET, Buisson A, Komesli S, Vivien D
J. Biol. Chem. 0021-9258
PMID : 11544249
KEYWORDS : Amino Acid Sequence|Animals|Base Sequence|Cell Division|physiology|Cell Line|Cricetinae|DNA Primers|Immunoglobulin G|metabolism|Mink|Molecular Sequence Data|Protein Conformation|Receptors, Transforming Growth Factor beta|chemistry|Sequence Homology, Amino Acid|Signal Transduction|Solubility|Transforming Growth Factor beta|metabolism
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Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress?
Ali C, Docagne F, Nicole O, Lesné S, Toutain J, Young A, Chazalviel L, Divoux D, Caly M, Cabal P, Derlon JM, MacKenzie ET, Buisson A, Vivien D
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 11435794
KEYWORDS : Animals|Biomarkers|Brain|metabolism|Brain Ischemia|etiology|Gene Expression|Magnetic Resonance Imaging|Male|Middle Cerebral Artery|surgery|Neurons|physiology|Oxygen Consumption|Papio|RNA, Messenger|analysis|Reverse Transcriptase Polymerase Chain Reaction|Tomography, Emission-Computed|Transforming Growth Factor beta|genetics
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Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.
Nicole O, Ali C, Docagne F, Plawinski L, MacKenzie ET, Vivien D, Buisson A
J. Neurosci. 1529-2401
PMID : 11312287
KEYWORDS : Animals|Apoptosis|drug effects|Astrocytes|cytology|Brain Ischemia|metabolism|Calcium|metabolism|Cerebral Cortex|cytology|Chelating Agents|Drosophila Proteins|Fluorescent Dyes|Glial Cell Line-Derived Neurotrophic Factor|Glial Cell Line-Derived Neurotrophic Factor Receptors|Glycosylphosphatidylinositols|metabolism|MAP Kinase Signaling System|drug effects|Membrane Proteins|metabolism|Mice|Mice, Inbred Strains|Mitogen-Activated Protein Kinases|metabolism|N-Methylaspartate|antagonists & inhibitors|Necrosis|Nerve
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The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.
Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D, Buisson A
Nat. Med. 1078-8956
PMID : 11135617
KEYWORDS : Animals|Calcium|metabolism|Cell Death|Hydrolysis|Ion Transport|Membrane Potentials|Neurons|metabolism|Receptors, N-Methyl-D-Aspartate|metabolism|Signal Transduction|Tissue Plasminogen Activator|metabolism
Show abstract [+]


Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain.
Ali C, Nicole O, Docagne F, Lesne S, MacKenzie ET, Nouvelot A, Buisson A, Vivien D
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 10894179
KEYWORDS : Animals|Apoptosis|drug effects|Astrocytes|cytology|Brain Chemistry|drug effects|Cells, Cultured|Cerebral Cortex|blood supply|Excitatory Amino Acid Agonists|pharmacology|Gene Expression|drug effects|Infarction, Middle Cerebral Artery|immunology|Interleukin-6|genetics|Ionomycin|pharmacology|Ionophores|pharmacology|Ischemic Attack, Transient|immunology|Male|N-Methylaspartate|pharmacology|Neurons|chemistry|Neuroprotective Agents|immunology|Neurotoxins|pharmacology|Polymerase Chain Reaction|RNA, Messenger|analys
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Serine protease inhibitors: novel therapeutic targets for stroke?
Vivien D, Buisson A
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 10826525
KEYWORDS : Animals|Cytokines|physiology|Humans|Neurodegenerative Diseases|physiopathology|Serine Endopeptidases|physiology|Serine Proteinase Inhibitors|physiology|Stroke|drug therapy
Show abstract [+]

Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain.
Bernaudin M, Bellail A, Marti HH, Yvon A, Vivien D, Duchatelle I, Mackenzie ET, Petit E
Glia 0894-1491
PMID : 10756076
KEYWORDS : Animals|Astrocytes|metabolism|Brain|metabolism|Cells, Cultured|Erythropoietin|genetics|Hypoxia|genetics|Male|Mice|Mice, Inbred Strains|Neurons|metabolism|Oxidation-Reduction|Oxygen|metabolism|Polymerase Chain Reaction|RNA, Messenger|metabolism|Time Factors
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A transforming growth factor-beta antagonist unmasks the neuroprotective role of this endogenous cytokine in excitotoxic and ischemic brain injury.
Ruocco A, Nicole O, Docagne F, Ali C, Chazalviel L, Komesli S, Yablonsky F, Roussel S, MacKenzie ET, Vivien D, Buisson A
J. Cereb. Blood Flow Metab. 0271-678X
PMID : 10598939
KEYWORDS : Animals|Cell Death|drug effects|Cells, Cultured|Cerebral Cortex|cytology|Cerebral Infarction|pathology|Fetus|Gene Expression Regulation|drug effects|Humans|Immunoglobulin Fc Fragments|Ischemic Attack, Transient|pathology|Male|Mice|Middle Cerebral Artery|N-Methylaspartate|toxicity|Neurons|cytology|Neuroprotective Agents|Protein-Serine-Threonine Kinases|Rats|Rats, Sprague-Dawley|Receptor, Transforming Growth Factor-beta Type II|Receptors, Transforming Growth Factor beta|genetics|Recombinant Fusion Proteins|ph
Show abstract [+]

Transforming growth factor-beta1 as a regulator of the serpins/t-PA axis in cerebral ischemia.
Docagne F, Nicole O, Marti HH, MacKenzie ET, Buisson A, Vivien D
FASEB J. 0892-6638
PMID : 10428756
KEYWORDS : Amyloid beta-Protein Precursor|Animals|Astrocytes|metabolism|Brain Ischemia|genetics|Carrier Proteins|genetics|Cell Death|genetics|Cells, Cultured|Gene Expression Regulation|Mice|Neurons|pathology|Neuropeptides|genetics|Plasminogen Activator Inhibitor 1|genetics|Protease Nexins|Receptors, Cell Surface|Serpins|genetics|Tissue Plasminogen Activator|genetics|Transforming Growth Factor beta|genetics
Show abstract [+]


Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1.
Buisson A, Nicole O, Docagne F, Sartelet H, Mackenzie ET, Vivien D
FASEB J. 0892-6638
PMID : 9837858
KEYWORDS : Animals|Astrocytes|drug effects|Cell Death|drug effects|Mice|N-Methylaspartate|pharmacology|Neuroglia|cytology|Neurons|cytology|Neuroprotective Agents|pharmacology|Plasminogen Activator Inhibitor 1|metabolism|Receptors, Transforming Growth Factor beta|genetics|Serine Proteinase Inhibitors|biosynthesis|Tissue Plasminogen Activator|metabolism|Transforming Growth Factor beta|pharmacology|Up-Regulation
Show abstract [+]

Evidence of type I and type II transforming growth factor-beta receptors in central nervous tissues: changes induced by focal cerebral ischemia.
Vivien D, Bernaudin M, Buisson A, Divoux D, MacKenzie ET, Nouvelot A
J. Neurochem. 0022-3042
PMID : 9603194
KEYWORDS : Activin Receptors, Type I|Animals|Animals, Newborn|Arterial Occlusive Diseases|complications|Astrocytes|cytology|Cells, Cultured|Cerebral Arterial Diseases|complications|Cerebral Cortex|metabolism|Epithelial Cells|metabolism|Humans|Immunohistochemistry|Ischemic Attack, Transient|etiology|Mice|Mink|Neurons|cytology|Polymerase Chain Reaction|Protein-Serine-Threonine Kinases|biosynthesis|RNA, Messenger|biosynthesis|Receptor, Transforming Growth Factor-beta Type I|Receptor, Transforming Growth Factor-beta Type
Show abstract [+]


An inositolphosphate glycan released by TGF-beta mimics the proliferative but not the transcriptional effects of the factor and requires functional receptors.
Bogdanowicz P, Vivien D, Felisaz N, Léon V, Pujol JP
Cell. Signal. 0898-6568
PMID : 9023015
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Division|Cell Line|Cells, Cultured|DNA|biosynthesis|Gene Expression Regulation|Genes, Reporter|Inositol Phosphates|metabolism|Mink|Molecular Mimicry|Polysaccharides|metabolism|Rabbits|Receptors, Transforming Growth Factor beta|metabolism|Signal Transduction|Transcription, Genetic|Transforming Growth Factor beta|pharmacology
Show abstract [+]

[Physiopathology of arthrotic cartilage].
Pujol JP, Galéra P, Vivien D, Redini F, Boumediene K
Rev Prat 0035-2640
PMID : 8978150
KEYWORDS : Animals|Cartilage, Articular|metabolism|Humans|Osteoarthritis|metabolism|Rabbits|Receptors, Transforming Growth Factor beta|genetics|Transforming Growth Factor beta|genetics


Modulation of rabbit articular chondrocyte (RAC) proliferation by TGF-beta isoforms.
Boumediene K, Vivien D, Macro M, Bogdanowicz P, Lebrun E, Pujol JP
Cell Prolif. 0960-7722
PMID : 7772639
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Count|Cell Cycle|drug effects|Cell Division|drug effects|Cells, Cultured|Flow Cytometry|Rabbits|Thymidine|Transforming Growth Factor beta|biosynthesis|Tritium
Show abstract [+]

Ligand-induced recruitment and phosphorylation of reduced TGF-beta type I receptor.
Vivien D, Wrana JL
Exp. Cell Res. 0014-4827
PMID : 7589256
KEYWORDS : Animals|Cell Line|metabolism|Dithiothreitol|pharmacology|Epithelial Cells|Epithelium|ultrastructure|Ligands|Mink|Phosphorylation|Receptors, Transforming Growth Factor beta|metabolism|Signal Transduction|physiology
Show abstract [+]


Different phosphorylated forms of inositolphosphate glycan could be involved in the transforming growth factor-beta 1 (TGF-beta 1) signalling pathway.
Vivien D, Bogdanowicz P, Boumediene K, Martiny L, Haye B, Pujol JP
Cell. Signal. 0898-6568
PMID : 8086280
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|Cell Division|Cells, Cultured|Chromatography, Ion Exchange|DNA Replication|drug effects|Glucosamine|metabolism|Glycosylphosphatidylinositols|metabolism|Humans|Inositol Phosphates|metabolism|Phosphorylation|Polysaccharides|metabolism|Protein Kinases|metabolism|Rabbits|Signal Transduction|Transforming Growth Factor beta|metabolism
Show abstract [+]

Transforming growth factor-beta (TGF-beta) and articular chondrocytes.
Pujol JP, Galera P, Pronost S, Boumediene K, Vivien D, Macro M, Min W, Redini F, Penfornis H, Daireaux M
Ann. Endocrinol. (Paris) 0003-4266
PMID : 7802428
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Division|drug effects|Extracellular Matrix|metabolism|G2 Phase|Interleukin-1|antagonists & inhibitors|Rabbits|Receptors, Transforming Growth Factor beta|metabolism|Transforming Growth Factor beta|pharmacology
Show abstract [+]


Interleukin-1 and naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC).
Pronost S, Delecoeuillerie G, Rédini F, Paolozzi L, Vivien D, Galéra P, Loyau G, Pujol JP
Agents Actions Suppl. 0379-0363
PMID : 8456631
KEYWORDS : Arthritis, Rheumatoid|pathology|Down-Regulation|drug effects|Humans|Interleukin-1|metabolism|Iodine Radioisotopes|Kinetics|Naproxen|pharmacology|Receptors, Interleukin-1|drug effects|Recombinant Proteins|pharmacology|Synovial Membrane|pathology
Show abstract [+]

IPG (inositolphosphate glycan) as a cellular signal for TGF-beta 1 modulation of chondrocyte cell cycle.
Vivien D, Petitfrère E, Martiny L, Sartelet H, Galéra P, Haye B, Pujol JP
J. Cell. Physiol. 0021-9541
PMID : 8388000
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cell Division|Cells, Cultured|DNA Replication|drug effects|Glycosylphosphatidylinositols|physiology|Humans|Hydrolysis|Inositol Phosphates|metabolism|Phosphatidylinositol Diacylglycerol-Lyase|Phosphoinositide Phospholipase C|Phosphoric Diester Hydrolases|metabolism|Polysaccharides|metabolism|Rabbits|Receptors, Cell Surface|physiology|Receptors, Transforming Growth Factor beta|Signal Transduction|Transforming Growth Factor beta|pharmacology
Show abstract [+]

Human rheumatoid synovial cells (HRSC) in culture express TGF-beta receptors and are growth stimulated by the factor.
Pronost S, Rédini F, Vivien D, Galéra P, Pujol JP
Agents Actions Suppl. 0379-0363
PMID : 8384400
KEYWORDS : Arthritis, Rheumatoid|metabolism|Autoradiography|Cell Division|drug effects|Cells, Cultured|Cross-Linking Reagents|pharmacology|Electrophoresis, Polyacrylamide Gel|Humans|Iodine Radioisotopes|Kinetics|Receptors, Cell Surface|biosynthesis|Receptors, Transforming Growth Factor beta|Stimulation, Chemical|Synovial Membrane|cytology|Transforming Growth Factor beta|pharmacology
Show abstract [+]

Rabbit articular chondrocytes (RAC) express distinct transforming growth factor-beta receptor phenotypes as a function of cell cycle phases.
Vivien D, Redini F, Galéra P, Lebrun E, Loyau G, Pujol JP
Exp. Cell Res. 0014-4827
PMID : 8384118
KEYWORDS : Animals|Binding Sites|Cartilage, Articular|metabolism|Cell Cycle|physiology|Cell Division|drug effects|Cells, Cultured|drug effects|Phenotype|Rabbits|Receptors, Cell Surface|physiology|Receptors, Transforming Growth Factor beta|Transforming Growth Factor beta|metabolism
Show abstract [+]


Effect of transforming growth factor-beta 1 (TGF-beta 1) on matrix synthesis by monolayer cultures of rabbit articular chondrocytes during the dedifferentiation process.
Galéra P, Rédini F, Vivien D, Bonaventure J, Penfornis H, Loyau G, Pujol JP
Exp. Cell Res. 0014-4827
PMID : 1572404
KEYWORDS : Animals|Cartilage, Articular|metabolism|Cell Differentiation|drug effects|Cell Division|drug effects|Cells, Cultured|Collagen|biosynthesis|Extracellular Matrix|metabolism|Gene Expression|drug effects|Glycosaminoglycans|biosynthesis|In Vitro Techniques|Proteoglycans|metabolism|RNA, Messenger|genetics|Rabbits|Transforming Growth Factor beta|pharmacology
Show abstract [+]

Transforming growth factor-beta 1 (TGF-beta 1) up-regulation of collagen type II in primary cultures of rabbit articular chondrocytes (RAC) involves increased mRNA levels without affecting mRNA stability and procollagen processing.
Galéra P, Vivien D, Pronost S, Bonaventure J, Rédini F, Loyau G, Pujol JP
J. Cell. Physiol. 0021-9541
PMID : 1447320
KEYWORDS : Animals|Ascorbic Acid|pharmacology|Cartilage, Articular|cytology|Cells, Cultured|Collagen|metabolism|Dinoprostone|biosynthesis|Drug Stability|Electrophoresis, Polyacrylamide Gel|Homeostasis|Indomethacin|pharmacology|Isomerism|Procollagen|classification|Protein Processing, Post-Translational|drug effects|RNA, Messenger|metabolism|Rabbits|Transforming Growth Factor beta|pharmacology
Show abstract [+]

Flow cytometric detection of transforming growth factor-beta expression in rabbit articular chondrocytes (RAC) in culture--association with S-phase traverse.
Vivien D, Boumedienne K, Galera P, Lebrun E, Pujol JP
Exp. Cell Res. 0014-4827
PMID : 1426052
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|Cell Division|Cells, Cultured|DNA|analysis|Flow Cytometry|methods|Rabbits|S Phase|physiology|Transforming Growth Factor beta|biosynthesis
Show abstract [+]

TGF-beta-induced G2/M delay in proliferating rabbit articular chondrocytes is associated with an enhancement of replication rate and a cAMP decrease: possible involvement of pertussis toxin-sensitive pathway.
Vivien D, Galéra P, Lebrun E, Daireaux M, Loyau G, Pujol JP
J. Cell. Physiol. 0021-9541
PMID : 1346400
KEYWORDS : Adenylate Cyclase Toxin|Animals|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cholera Toxin|pharmacology|Cyclic AMP|metabolism|DNA Replication|drug effects|Flow Cytometry|In Vitro Techniques|Nuclear Proteins|metabolism|Pertussis Toxin|Proliferating Cell Nuclear Antigen|Rabbits|Transforming Growth Factor beta|pharmacology|Virulence Factors, Bordetella|pharmacology
Show abstract [+]


Differential response of cultured rabbit articular chondrocytes (RAC) to transforming growth factor beta (TGF-beta)-evidence for a role of serum factors.
Vivien D, Galera P, Loyau G, Pujol JP
Eur. J. Cell Biol. 0171-9335
PMID : 1879436
KEYWORDS : Animals|Blood|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cell Division|drug effects|Cells, Cultured|Culture Media|DNA|biosynthesis|Epidermal Growth Factor|pharmacology|Kinetics|Platelet-Derived Growth Factor|pharmacology|Rabbits|Transforming Growth Factor beta|pharmacology
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Differential effects of transforming growth factor-beta and epidermal growth factor on the cell cycle of cultured rabbit articular chondrocytes.
Vivien D, Galéra P, Lebrun E, Loyau G, Pujol JP
J. Cell. Physiol. 0021-9541
PMID : 2358472
KEYWORDS : Animals|Cartilage, Articular|cytology|Cell Cycle|drug effects|Cell Division|drug effects|Cells, Cultured|DNA|biosynthesis|Epidermal Growth Factor|pharmacology|Plateletpheresis|Rabbits|Transforming Growth Factors|pharmacology
Show abstract [+]

Transforming growth factor-beta signalling in brain disorders.
Vivien D, Ali C
Cytokine Growth Factor Rev. 1359-6101
PMID : 16271500
KEYWORDS : Animals|Brain Diseases|drug therapy|Disease Progression|Humans|Receptors, Transforming Growth Factor beta|physiology|Signal Transduction|physiology|Transforming Growth Factor beta|physiology
Show abstract [+]